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EHP

May 2016 CoverMay 2016 | Volume 124 | Issue 5

On the Cover

The emerging field of sewage chemical-information mining is taking advantage of a readily available yet underappreciated resource: the untreated waste flowing under our feet and the biosolids remaining after treatment. It turns out that sewage and sewage sludge hold a wealth of data on chemical consumption and exposure, and potentially even the health status of whole communities.

EHP

May 2016 | Volume 124 | Issue 5

News

Pipe Dreams: Tapping into the Health Information in Our Sewers

Carrie Arnold | A86

Cleaning Up Muddy Waters: The Fight to Revive Senegal’s Hann Bay

Jori Lewis | A92

Prenatal Air Pollution and Reduced Birth Weight: Decline in Placental Mitochondria as a Potential Mechanism

Julia R. Barrett | A98

Also see Clemente et al., p. 659

Commentaries

E-Waste and Harm to Vulnerable Populations: A Growing Global Problem

Michelle Heacock, Carol Bain Kelly, Kwadwo Ansong Asante, Linda S. Birnbaum, Åke Lennart Bergman, Marie-Noel Bruné, Irena Buka, David O. Carpenter, Aimin Chen, Xia Huo, Mostafa Kamel, Philip J. Landrigan, Federico Magalini, Fernando Diaz-Barriga, Maria Neira, Magdy Omar, Antonio Pascale, Mathuros Ruchirawat, Leith Sly, Peter D. Sly, Martin Van den Berg, and William A. Suk | 550

Reviews

A Curated Database of Rodent Uterotrophic Bioactivity

Nicole C. Kleinstreuer, Patricia C. Ceger, David G. Allen, Judy Strickland, Xiaoqing Chang, Jonathan T. Hamm, and Warren M. Casey | 556

Research

Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells

Shawn Pan, Chaoshen Yuan, Abderrahmane Tagmount, Ruthann A. Rudel, Janet M. Ackerman, Paul Yaswen, Chris D. Vulpe, and Dale C. Leitman | 563

Organophosphate Pesticide Exposures, Nitric Oxide Synthase Gene Variants, and Gene–Pesticide Interactions in a Case–Control Study of Parkinson’s Disease, California (USA)

Kimberly C. Paul, Janet S. Sinsheimer, Shannon L. Rhodes, Myles Cockburn, Jeff Bronstein, and Beate Ritz | 570

Residential Road Traffic Noise and High Depressive Symptoms after Five Years of Follow-up: Results from the Heinz Nixdorf Recall Study

Ester Orban, Kelsey McDonald, Robynne Sutcliffe, Barbara Hoffmann, Kateryna B. Fuks, Nico Dragano, Anja Viehmann, Raimund Erbel, Karl-Heinz Jöckel, Noreen Pundt, and Susanne Moebus | 578

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits

Windy A. Boyd, Marjolein V. Smith, Caroll A. Co, Jason R. Pirone, Julie R. Rice, Keith R. Shockley, and Jonathan H. Freedman | 586

Blood Cadmium Levels and Incident Cardiovascular Events during Follow-up in a Population-Based Cohort of Swedish Adults: The Malmö Diet and Cancer Study

Lars Barregard, Gerd Sallsten, Björn Fagerberg, Yan Borné, Margaretha Persson, Bo Hedblad, and Gunnar Engström | 594

Cross-Talk in the Female Rat Mammary Gland: Influence of Aryl Hydrocarbon Receptor on Estrogen Receptor Signaling

Janina Helle, Manuela I. Bader, Annekathrin M. Keiler, Oliver Zierau, Günter Vollmer, Sridar V. Chittur, Martin Tenniswood, and Georg Kretzschmar | 601

Use of Dieselized Farm Equipment and Incident Lung Cancer: Findings from the Agricultural Health Study Cohort

Séverine Tual, Debra T. Silverman, Stella Koutros, Aaron Blair, Dale P. Sandler, Pierre Lebailly, Gabriella Andreotti, Jane A. Hoppin, and Laura E. Beane Freeman | 611

Fine-Scale Exposure to Allergenic Pollen in the Urban Environment: Evaluation of Land Use Regression Approach

Jan Hjort, Timo T. Hugg, Harri Antikainen, Jarmo Rusanen, Mikhail Sofiev, Jaakko Kukkonen, Maritta S. Jaakkola, and Jouni J.K. Jaakkola | 619

Modeling and Prediction of Oyster Norovirus Outbreaks along Gulf of Mexico Coast

Jiao Wang and Zhiqiang Deng | 627

Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data

Marlene Thai Kim, Ruili Huang, Alexander Sedykh, Wenyi Wang, Menghang Xia, and Hao Zhu | 634

Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice

Gregory J. Smith, Joseph A. Cichocki, Bennett J. Doughty, Jose E. Manautou, Sven-Eric Jordt, and John B. Morris | 642

Cross-sectional Associations between Exposure to Persistent Organic Pollutants and Leukocyte Telomere Length among U.S. Adults in NHANES, 2001–2002

Susanna D. Mitro, Linda S. Birnbaum, Belinda L. Needham, and Ami R. Zota | 651

Children’s Health

Prenatal Ambient Air Pollution, Placental Mitochondrial DNA Content, and Birth Weight in the INMA (Spain) and ENVIRONAGE (Belgium) Birth Cohorts

Diana B.P. Clemente, Maribel Casas, Nadia Vilahur, Haizea Begiristain, Mariona Bustamante, Anne-Elie Carsin, Mariana F. Fernández, Frans Fierens, Wilfried Gyselaers, Carmen Iñiguez, Bram G. Janssen, Wouter Lefebvre, Sabrina Llop, Nicolás Olea, Marie Pedersen, Nicky Pieters, Loreto Santa Marina, Ana Souto, Adonina Tardón, Charlotte Vanpoucke, Martine Vrijheid, Jordi Sunyer, and Tim S. Nawrot | 659

Also see Science Selections, p. A98

Lead Exposure during Early Human Development and DNA Methylation of Imprinted Gene Regulatory Elements in Adulthood

Yue Li, Changchun Xie, Susan K. Murphy, David Skaar, Monica Nye, Adriana C. Vidal, Kim M. Cecil, Kim N. Dietrich, Alvaro Puga, Randy L. Jirtle, and Cathrine Hoyo | 666

Organophosphate Insecticide Metabolites in Prenatal and Childhood Urine Samples and Intelligence Scores at 6 Years of Age: Results from the Mother–Child PELAGIE Cohort (France)

Chloé Cartier, Charline Warembourg, Gaïd Le Maner-Idrissi, Agnès Lacroix, Florence Rouget, Christine Monfort, Gwendolina Limon, Gaël Durand, Dave Saint-Amour, Sylvaine Cordier, and Cécile Chevrier | 674

Birth Weight, Ethnicity, and Exposure to Trihalomethanes and Haloacetic Acids in Drinking Water during Pregnancy in the Born in Bradford Cohort

Rachel B. Smith, Susan C. Edwards, Nicky Best, John Wright, Mark J. Nieuwenhuijsen, and Mireille B. Toledano | 681

Pediatric Emergency Visits and Short-Term Changes in PM2.5 Concentrations in the U.S. State of Georgia

Matthew J. Strickland, Hua Hao, Xuefei Hu, Howard H. Chang, Lyndsey A. Darrow, and Yang Liu | 690

Perspectives

Editorials

Crumbling Infrastructure and Learning Impairment: A Call for Responsibility

Edward D. Levin | A79

In Memoriam

In Memoriam: Carol Stroebel

Nsedu Obot Witherspoon | A80

Brief Communications

Uppsala Consensus Statement on Environmental Contaminants and the Global Obesity Epidemic

Lars Lind, P. Monica Lind, Margareta H. Lejonklou, Linda Dunder, Åke Bergman, Carlos Guerrero-Bosagna, Erik Lampa, Hong Kyu Lee, Juliette Legler, Angel Nadal, Youngmi Kim Pak, Richard P. Phipps, Laura N. Vandenberg, Daniel Zalko, Marlene Ågerstrand, Mattias Öberg, Bruce Blumberg, Jerrold J. Heindel, and Linda S. Birnbaum | A81

Correspondence

Comment on “Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research”

Ray Greek | A84

Response to “Comment on ‘Lessons from Toxicology: Developing a 21st-Century Paradigm for Medical Research’”

Gill Langley | A85

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