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February 2015 CoverFebruary 2015 | Volume 123 | Issue 2

On the Cover

Viewpoints on the human health risks of marine plastic pollution are nearly as complex as the underlying science. How much do plastics contribute to the chemical burden in seafood? What proportion of human exposure to plastic ingredients occurs through seafood? And how concerned should we be about exposures to marine plastic pollution?

© Zoran Milich/Getty Images

February 2015 | Volume 123 | Issue 2


New Link in the Food Chain? Marine Plastic Pollution and Seafood Safety

Nate Seltenrich | A34

Seeds of Toxicity? Erythrocytes and Lead-Associated Kidney Damage

Julia R. Barrett | A42

Also see Kwon et al., p. 120

The View from Afar: Satellite-Derived Estimates of Global PM2.5

Lindsey Konkel | A43

Also see van Donkelaar et al., p. 135

Tracking Alternative Flame Retardants: Hand-to-Mouth Exposures in Adults

Kellyn S. Betts | A44

Also see Hoffman et al., p. 160

Shrimp Consumption after Deepwater Horizon: No Evidence of Excess Risks for Vietnamese Americans

Janet Pelley | A45

Also see Wilson et al., p. 152


Evaluating Health Risks from Inhaled Polychlorinated Biphenyls: Research Needs for Addressing Uncertainty

Geniece M. Lehmann, Krista Christensen, Mark Maddaloni, and Linda J. Phillips | 109

Human Health Effects of Dichloromethane: Key Findings and Scientific Issues

Paul M. Schlosser, Ambuja S. Bale, Catherine F. Gibbons, Amina Wilkins, and Glinda S. Cooper | 114


Erythrophagocytosis of Lead-Exposed Erythrocytes by Renal Tubular Cells: Possible Role in Lead-Induced Nephrotoxicity

So-Youn Kwon, Ok-Nam Bae, Ji-Yoon Noh, Keunyoung Kim, Seojin Kang, Young-Jun Shin, Kyung-Min Lim, and Jin-Ho Chung | 120

Also see Science Selections, p. A42

Association between Lifetime Exposure to Inorganic Arsenic in Drinking Water and Coronary Heart Disease in Colorado Residents

Katherine A. James, Tim Byers, John E. Hokanson, Jaymie R. Meliker, Gary O. Zerbe, and Julie A. Marshall | 128

Use of Satellite Observations for Long-Term Exposure Assessment of Global Concentrations of Fine Particulate Matter

Aaron van Donkelaar, Randall V. Martin, Michael Brauer, and Brian L. Boys | 135

Also see Science Selections, p. A43

Air Pollution and Percent Emphysema Identified by Computed Tomography in the Multi-Ethnic Study of Atherosclerosis

Sara D. Adar, Joel D. Kaufman, Ana V. Diez-Roux, Eric A. Hoffman, Jennifer D’Souza, Karen H. Stukovsky, Stephen S. Rich, Jerome I. Rotter, Xiuqing Guo, Leslie J. Raffel, Paul D. Sampson, Assaf P. Oron, Trivellore Raghunathan, and R. Graham Barr | 144

A Targeted Health Risk Assessment Following the Deepwater Horizon Oil Spill: Polycyclic Aromatic Hydrocarbon Exposure in Vietnamese-American Shrimp Consumers

Mark J. Wilson, Scott Frickel, Daniel Nguyen, Tap Bui, Stephen Echsner, Bridget R. Simon, Jessi L. Howard, Kent Miller, and Jeffrey K. Wickliffe | 152

Also see Science Selections, p. A45

Monitoring Indoor Exposure to Organophosphate Flame Retardants: Hand Wipes and House Dust

Kate Hoffman, Stavros Garantziotis, Linda S. Birnbaum, and Heather M. Stapleton | 160

Also see Science Selections, p. A44

Characterizing the Peroxisome Proliferator-Activated Receptor (PPARγ) Ligand Binding Potential of Several Major Flame Retardants, Their Metabolites, and Chemical Mixtures in House Dust

Mingliang Fang, Thomas F. Webster, P. Lee Ferguson, and Heather M. Stapleton | 166

Children’s Health

A Prospective Study of Growth and Biomarkers of Exposure to Aflatoxin and Fumonisin during Early Childhood in Tanzania

Candida P. Shirima, Martin E. Kimanya, Michael N. Routledge, Chou Srey, Joyce L. Kinabo, Hans-Ulrich Humpf, Christopher P. Wild, Yu-Kang Tu, and Yun Yun Gong | 173

Early-life Exposure to Organophosphate Pesticides and Pediatric Respiratory Symptoms in the CHAMACOS Cohort

Rachel Raanan, Kim G. Harley, John R. Balmes, Asa Bradman, Michael Lipsett, and Brenda Eskenazi | 179

Maternal Arsenic Exposure, Arsenic Methylation Efficiency, and Birth Outcomes in the Biomarkers of Exposure to ARsenic (BEAR) Pregnancy Cohort in Mexico

Jessica E. Laine, Kathryn A. Bailey, Marisela Rubio-Andrade, Andrew F. Olshan, Lisa Smeester, Zuzana Drobná, Amy H. Herring, Miroslav Stýblo, Gonzalo G. García-Vargas, and Rebecca C. Fry | 186

Prenatal Exposure to Maternal Cigarette Smoking and DNA Methylation: Epigenome-Wide Association in a Discovery Sample of Adolescents and Replication in an Independent Cohort at Birth through 17 Years of Age

Ken W.K. Lee, Rebecca Richmond, Pingzhao Hu, Leon French, Jean Shin, Celine Bourdon, Eva Reischl, Melanie Waldenberger, Sonja Zeilinger, Tom Gaunt, Wendy McArdle, Susan Ring, Geoff Woodward, Luigi Bouchard, Daniel Gaudet, George Davey Smith, Caroline Relton, Tomas Paus, and Zdenka Pausova | 193


Estimating the Number of Vulnerable People in the United States Exposed to Residential Wood Smoke

Curtis W. Noonan, Tony J. Ward, and Erin O. Semmens | A30

Estimating the Number of Vulnerable People in the United States Exposed to Residential Wood Smoke: Rogalsky et al. Respond

Derek K. Rogalsky, Pauline Mendola, Tricia A. Metts, and William J. Martin II | A30


Erratum: “A Prospective Study of Growth and Biomarkers of Exposure to Aflatoxin and Fumonisin during Early Childhood in Tanzania”


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