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EHP

September 2014 coverSeptember 2014 | Volume 122 | Issue 9

On the Cover

The elderly population is growing rapidly, and factors that affect this group are of increasing importance, particularly neurological diseases and disorders typically associated with advanced age. Investigators are studying the effects of not just present-day exposures and environmental influences such as physical and mental exercise, but also exposures that occurred much earlier in life, whose effects may only become apparent in old age.

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September 2014 | Volume 122 | Issue 9

News

Time after Time: Environmental Influences on the Aging Brain

Elizabeth Grossman | A238

Vaping and Health: What Do We Know about E-Cigarettes?

Carrie Arnold | A244

Echoes of Autism? Inhaled Ultrafine Particles and Brain Changes in Mice

Carol Potera | A250

Also see Allen et al., p. 939

Hydroxymethylation and Metals: A New Epigenetic Marker for Toxic Exposures

Lindsey Konkel | A251

Also see Tellez-Plaza et al., p. 946

Assessing the Health Threat of Outdoor Air: Lung Cancer Risk and Particulate Matter Exposure

Julia R. Barrett | A252

Also see Hamra et al., p. 906

Priorities for Breast Cancer Research: Taking Stock of Chemicals, Biomarkers, and Exposure Assessment Tools

Nancy Averett | A253

Also see Rudel et al., p. 881

Reviews

New Exposure Biomarkers as Tools for Breast Cancer Epidemiology, Biomonitoring, and Prevention: A Systematic Approach Based on Animal Evidence

Ruthann A. Rudel, Janet M. Ackerman, Kathleen R. Attfield, and Julia Green Brody | 881

Also see Science Selections, p. A253

Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)

Kateryna B. Fuks, Gudrun Weinmayr, Maria Foraster, Julia Dratva, Regina Hampel, Danny Houthuijs, Bente Oftedal, Anna Oudin, Sviatlana Panasevich, Johanna Penell, Johan N. Sommar, Mette Sørensen, Pekka Tiittanen, Kathrin Wolf, Wei W. Xun, Inmaculada Aguilera, Xavier Basagaña, Rob Beelen, Michiel L. Bots, Bert Brunekreef, H. Bas Bueno-de-Mesquita, Barbara Caracciolo, Marta Cirach, Ulf de Faire, Audrey de Nazelle, Marloes Eeftens, Roberto Elosua, Raimund Erbel, Bertil Forsberg, Laura Fratiglioni, Jean-Michel Gaspoz, Agneta Hilding, Antti Jula, Michal Korek, Ursula Krämer, Nino Künzli, Timo Lanki, Karin Leander, Patrik K.E. Magnusson, Jaume Marrugat, Mark J. Nieuwenhuijsen, Claes-Göran Östenson, Nancy L. Pedersen, Göran Pershagen, Harish C. Phuleria, Nicole M. Probst-Hensch, Ole Raaschou-Nielsen, Emmanuel Schaffner, Tamara Schikowski, Christian Schindler, Per E. Schwarze, Anne J. Søgaard, Dorothea Sugiri, Wim J.R. Swart, Ming-Yi Tsai, Anu W. Turunen, Paolo Vineis, Annette Peters, and Barbara Hoffmann | 896

Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis

Ghassan B. Hamra, Neela Guha, Aaron Cohen, Francine Laden, Ole Raaschou-Nielsen, Jonathan M. Samet, Paolo Vineis, Francesco Forastiere, Paulo Saldiva, Takashi Yorifuji, and Dana Loomis | 906

Also see Science Selections, p. A252

Research

Using Forecast and Observed Weather Data to Assess Performance of Forecast Products in Identifying Heat Waves and Estimating Heat Wave Effects on Mortality

Kai Zhang, Yeh-Hsin Chen, Joel D. Schwartz, Richard B. Rood, and Marie S. O’Neill | 912

Long-Term Exposure to Ambient Air Pollution and Incidence of Cerebrovascular Events: Results from 11 European Cohorts within the ESCAPE Project

Massimo Stafoggia, Giulia Cesaroni, Annette Peters, Zorana J. Andersen, Chiara Badaloni, Rob Beelen, Barbara Caracciolo, Josef Cyrys, Ulf de Faire, Kees de Hoogh, Kirsten T. Eriksen, Laura Fratiglioni, Claudia Galassi, Bruna Gigante, Aki S. Havulinna, Frauke Hennig, Agneta Hilding, Gerard Hoek, Barbara Hoffmann, Danny Houthuijs, Michal Korek, Timo Lanki, Karin Leander, Patrik K. Magnusson, Christa Meisinger, Enrica Migliore, Kim Overvad, Claes-Göran Östenson, Nancy L. Pedersen, Juha Pekkanen, Johanna Penell, Goran Pershagen, Noreen Pundt, Andrei Pyko, Ole Raaschou-Nielsen, Andrea Ranzi, Fulvio Ricceri, Carlotta Sacerdote, Wim J.R. Swart, Anu W. Turunen, Paolo Vineis, Christian Weimar, Gudrun Weinmayr, Kathrin Wolf, Bert Brunekreef, and Francesco Forastiere | 919

Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the Nurses’ Health Study Cohort

Robin C. Puett, Jaime E. Hart, Jeff D. Yanosky, Donna Spiegelman, Molin Wang, Jared A. Fisher, Biling Hong, and Francine Laden | 926

A Prospective Analysis of Airborne Metal Exposures and Risk of Parkinson Disease in the Nurses’ Health Study Cohort

Natalia Palacios, Kathryn Fitzgerald, Andrea L. Roberts, Jaime E. Hart, Marc G. Weisskopf, Michael A. Schwarzschild, Alberto Ascherio, and Francine Laden | 933

Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution: Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in Male Mice

Joshua L. Allen, Xiufang Liu, Sean Pelkowski, Brian Palmer, Katherine Conrad, Günter Oberdörster, Douglas Weston, Margot Mayer-Pröschel, and Deborah A. Cory-Slechta | 939

Also see Science Selections, p. A250

Association of Global DNA Methylation and Global DNA Hydroxymethylation with Metals and Other Exposures in Human Blood DNA Samples

Maria Tellez-Plaza, Wan-yee Tang, Yan Shang, Jason G. Umans, Kevin A. Francesconi, Walter Goessler, Marta Ledesma, Montserrat Leon, Martin Laclaustra, Jonathan Pollak, Eliseo Guallar, Shelley A. Cole, M. Dani Fallin, and Ana Navas-Acien | 946

Also see Science Selections, p. A251

Acrolein-Exposed Normal Human Lung Fibroblasts in Vitro: Cellular Senescence, Enhanced Telomere Erosion, and Degradation of Werner’s Syndrome Protein

Jun-Ho Jang, Shannon Bruse, Salam Huneidi, Ronald M. Schrader, Martha M. Monick, Yong Lin, A. Brent Carter, Aloysius J. Klingelhutz, and Toru Nyunoya | 955

Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster® 550

Kate Hoffman, Mingliang Fang, Brian Horman, Heather B. Patisaul, Stavros Garantziotis, Linda S. Birnbaum, and Heather M. Stapleton | 963

Spatiotemporal Modeling of Ozone Levels in Quebec (Canada): A Comparison of Kriging, Land-Use Regression (LUR), and Combined Bayesian Maximum Entropy–LUR Approaches

Ariane Adam-Poupart, Allan Brand, Michel Fournier, Michael Jerrett, and Audrey Smargiassi  | 970

Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort

Jitender Kumar, P. Monica Lind, Samira Salihovic, Bert van Bavel, Erik Ingelsson, and Lars Lind | 977

Pesticide Exposure and Depression among Male Private Pesticide Applicators in the Agricultural Health Study

John D. Beard, David M. Umbach, Jane A. Hoppin, Marie Richards, Michael C.R. Alavanja, Aaron Blair, Dale P. Sandler, and Freya Kamel | 984

Children’s Health

Exposure to Fine Particulate Matter during Pregnancy and Risk of Preterm Birth among Women in New Jersey, Ohio, and Pennsylvania, 2000–2005

Kristen M. Rappazzo, Julie L. Daniels, Lynne C. Messer, Charles Poole, and Danelle T. Lobdell | 992

A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

Hanne Frederiksen, Tanja Kuiri-Hänninen, Katharina M. Main, Leo Dunkel, and Ulla Sankilampi | 998

Correspondence

Meta-Analysis of Lung Cancer Risk from Exposure to Diesel Exhaust: Study Limitations

Kenny Crump | A230

Meta-Analysis of Lung Cancer Risk from Exposure to Diesel Exhaust: Vermeulen et al. Respond

Roel Vermeulen, Lutzen Portengen, Debra T. Silverman, Eric Garshick, and Kyle Steenland | A230

Birth Outcomes and Natural Gas Development: Methodological Limitations

Kristen Fedak, Sherilyn Gross, Megan Jacobsen, and Brooke Tvermoes | A232

Birth Outcomes and Natural Gas Development: McKenzie et al. Respond

Lisa M. McKenzie, Ruixin Guo, Roxana Z. Witter, David A. Savitz, Lee S. Newman, and John L. Adgate | A232

Errata

Erratum: “Instruments for Assessing Risk of Bias and Other Methodological Criteria of Animal Studies: Omission of Well-Established Methods”

A234

Erratum: “An Integrated Risk Function for Estimating the Global Burden of Disease Attributable to Ambient Fine Particulate Matter Exposure”

A235

Erratum: “Outdoor Particulate Matter Exposure and Lung Cancer: A Systematic Review and Meta-Analysis”

A236

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