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July 2016 Cover
July 2016 | Volume 124 | Issue 7

On the Cover

Recent advances in molecular and imaging technologies, “omics” fields, and data sciences are offering researchers an unprecedented look at the placenta, the master regulator of the fetal environment.

© EPA/National Geographic Channel/Alamy

July 2016 | Volume 124 | Issue 7

News

Lasting Impact of an Ephemeral Organ: The Role of the Placenta in Fetal Programming

Lindsey Konkel | A124

Stroma Insights: Potential Mechanism for Arsenic-Induced Prostate Cancer

Julia R. Barrett | A130

Also see Shearer et al., p. 1009

Different People, Different Outcomes: Assessing Genetic Susceptibility to Lead Exposures

Julia R. Barrett | A131

Also see Zhou et al., p. 1062

Commentaries

Recommendations for Evaluating Temporal Trends of Persistent Organic Pollutants in Breast Milk

Tenzing Gyalpo, Martin Scheringer, and Konrad Hungerbühler | 881

Assessing the Health Impact of Water Quality Interventions in Low-Income Settings: Concerns Associated with Blinded Trials and the Need for Objective Outcomes

Thomas Clasen and Sophie Boisson | 886

Reviews

Arsenic and Environmental Health: State of the Science and Future Research Opportunities

Danielle J. Carlin, Marisa F. Naujokas, Karen D. Bradham, John Cowden, Michelle Heacock, Heather F. Henry, Janice S. Lee, David J. Thomas, Claudia Thompson, Erik J. Tokar, Michael P. Waalkes, Linda S. Birnbaum, and William A. Suk | 890

A Review of Health Risks and Pathways for Exposure to Wastewater Use in Agriculture

Sarah K. Dickin, Corinne J. Schuster-Wallace, Manzoor Qadir, and Katherine Pizzacalla | 900

Research

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

Imran Shah, R. Woodrow Setzer, John Jack, Keith A. Houck, Richard S. Judson, Thomas B. Knudsen, Jie Liu, Matthew T. Martin, David M. Reif, Ann M. Richard, Russell S. Thomas, Kevin M. Crofton, David J. Dix, and Robert J. Kavlock | 910

Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice

Hammoudi Alkaissi, Jimmy Ekstrand, Aksa Jawad, Jesper Bo Nielsen, Said Havarinasab, Peter Soderkvist, and Per Hultman | 920

Modification of Heat-Related Mortality in an Elderly Urban Population by Vegetation (Urban Green) and Proximity to Water (Urban Blue): Evidence from Lisbon, Portugal

Katrin Burkart, Fred Meier, Alexandra Schneider, Susanne Breitner, Paulo Canário, Maria João Alcoforado, Dieter Scherer, and Wilfried Endlicher | 927

Cross-Sectional Associations of Serum Perfluoroalkyl Acids and Thyroid Hormones in U.S. Adults: Variation According to TPOAb and Iodine Status (NHANES 2007–2008)

Glenys M. Webster, Stephen A. Rauch, Nathalie Ste Marie, Andre Mattman, Bruce P. Lanphear, and Scott A. Venners | 935

Biomolecular Markers within the Core Axis of Aging and Particulate Air Pollution Exposure in the Elderly: A Cross-Sectional Study

Nicky Pieters, Bram G. Janssen, Harrie Dewitte, Bianca Cox, Ann Cuypers, Wouter Lefebvre, Karen Smeets, Charlotte Vanpoucke, Michelle Plusquin, and Tim S. Nawrot | 943

Sperm Aneuploidy in Faroese Men with Lifetime Exposure to Dichlorodiphenyldichloroethylene (p,p´-DDE) and Polychlorinated Biphenyl (PCB) Pollutants

Melissa J. Perry, Heather A. Young, Philippe Grandjean, Jónrit Halling, Maria Skaalum Petersen, Sheena E. Martenies, Parisa Karimi, and Pál Weihe | 951

Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on ­Long-­term ­Self-­renewal of Murine Hematopoietic Stem Cells

Michael D. Laiosa, Everett R. Tate, Lori S. Ahrenhoerster, Yuhong Chen, and Demin Wang | 957

Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population

Xiaoyan Zhu, Jun Li, Siyun Deng, Kuai Yu, Xuezhen Liu, Qifei Deng, Huizhen Sun, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen, Jing Yuan, Bing Zhang, Dan Kuang, Xiaosheng He, Yansen Bai, Xu Han, Bing Liu, Xiaoliang Li, Liangle Yang, Haijing Jiang, Yizhi Zhang, Jie Hu, Longxian Cheng, Xiaoting Luo, Wenhua Mei, Zhiming Zhou, Shunchang Sun, Liyun Zhang, Chuanyao Liu, Yanjun Guo, Zhihong Zhang, Frank B. Hu, Liming Liang, and Tangchun Wu | 966

Mutagenicity and Pollutant Emission Factors of Solid-Fuel Cookstoves: Comparison with Other Combustion Sources

Esra Mutlu, Sarah H. Warren, Seth M. Ebersviller, Ingeborg M. Kooter, Judith E. Schmid, Janice A. Dye, William P. Linak, M. Ian Gilmour, James J. Jetter, Mark Higuchi, and David M. DeMarini | 974

Genome-Wide Analysis of DNA Methylation and Fine Particulate Matter Air Pollution in Three Study Populations: KORA F3, KORA F4, and the Normative Aging Study

Tommaso Panni, Amar J. Mehta, Joel D. Schwartz, Andrea A. Baccarelli, Allan C. Just, Kathrin Wolf, Simone Wahl, Josef Cyrys, Sonja Kunze, Konstantin Strauch, Melanie Waldenberger, and Annette Peters | 983

In Vitro Effects of the Endocrine Disruptor p,p´-DDT on Human Follitropin Receptor

Mathilde Munier, Julie Grouleff, Louis Gourdin, Mathilde Fauchard, Vanessa Chantreau, Daniel Henrion, Régis Coutant, Birgit Schiøtt, Marie Chabbert, and Patrice Rodien | 991

Exposure to Traffic-Related Air Pollution in Relation to Progression in Physical Disability among Older Adults

Jennifer Weuve, Joel D. Kaufman, Adam A. Szpiro, Cynthia Curl, Robin C. Puett, Todd Beck, Denis A. Evans, and Carlos F. Mendes de Leon | 1000

Inorganic Arsenic–Related Changes in the Stromal Tumor Microenvironment in a Prostate Cancer Cell–Conditioned Media Model

Joseph J. Shearer, Eric A. Wold, Charles S. Umbaugh, Cheryl F. Lichti, Carol L. Nilsson, and Marxa L. Figueiredo | 1009

Also see Science Selections, p. A130

Methods to Estimate Acclimatization to Urban Heat Island Effects on Heat- and Cold-Related Mortality

Ai Milojevic, Ben G. Armstrong, Antonio Gasparrini, Sylvia I. Bohnenstengel, Benjamin Barratt, and Paul Wilkinson | 1016

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

Kamel Mansouri, Ahmed Abdelaziz, Aleksandra Rybacka, Alessandra Roncaglioni, Alexander Tropsha, Alexandre Varnek, Alexey Zakharov, Andrew Worth, Ann M. Richard, Christopher M. Grulke, Daniela Trisciuzzi, Denis Fourches, Dragos Horvath, Emilio Benfenati, Eugene Muratov, Eva Bay Wedebye, Francesca Grisoni, Giuseppe F. Mangiatordi, Giuseppina M. Incisivo, Huixiao Hong, Hui W. Ng, Igor V. Tetko, Ilya Balabin, Jayaram Kancherla, Jie Shen, Julien Burton, Marc Nicklaus, Matteo Cassotti, Nikolai G. Nikolov, Orazio Nicolotti, Patrik L. Andersson, Qingda Zang, Regina Politi, Richard D. Beger, Roberto Todeschini, Ruili Huang, Sherif Farag, Sine A. Rosenberg, Svetoslav Slavov, Xin Hu, and Richard S. Judson | 1023

A Systems Biology Approach Reveals Converging Molecular Mechanisms that Link Different POPs to Common Metabolic Diseases

Patricia Ruiz, Ally Perlina, Moiz Mumtaz, and Bruce A. Fowler | 1034

Ingested Nitrate and Breast Cancer in the Spanish Multicase–Control Study on Cancer (MCC-Spain)

Nadia Espejo-Herrera, Esther Gracia-Lavedan, Marina Pollan, Nuria Aragonés, Elena Boldo, Beatriz Perez-Gomez, Jone M. Altzibar, Pilar Amiano, Ana Jiménez Zabala, Eva Ardanaz, Marcela Guevara, Antonio J. Molina, Juan Pablo Barrio, Ines Gómez-Acebo, Adonina Tardón, Rosana Peiró, Maria Dolores Chirlaque, Margarita Palau, Montse Muñoz, Laia Font-Ribera, Gemma Castaño-Vinyals, Manolis Kogevinas, and Cristina M. Villanueva | 1042

Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes

Maxwell C.K. Leung, Jimmy Phuong, Nancy C. Baker, Nisha S. Sipes, Gary R. Klinefelter, Matthew T. Martin, Keith W. McLaurin, R. Woodrow Setzer, Sally Perreault Darney, Richard S. Judson, and Thomas B. Knudsen | 1050

The Genetic Basis for Variation in Sensitivity to Lead Toxicity in Drosophila melanogaster

Shanshan Zhou, Tatiana V. Morozova, Yasmeen N. Hussain, Sarah E. Luoma, Lenovia McCoy, Akihiko Yamamoto, Trudy F.C. Mackay, and Robert R.H. Anholt | 1062

Also see Science Selections, p. A131

Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity

Christoph F.A. Vogel, W.L. William Chang, Sarah Kado, Kelly McCulloh, Helena Vogel, Dalei Wu, Thomas Haarmann-Stemmann, GuoXiang Yang, Patrick S.C. Leung, Fumio Matsumura, and M. Eric Gershwin | 1071

Children’s Health

Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies

Kim G. Harley, Stephanie M. Engel, Michelle G. Vedar, Brenda Eskenazi, Robin M. Whyatt, Bruce P. Lanphear, Asa Bradman, Virginia A. Rauh, Kimberly Yolton, Richard W. Hornung, James G. Wetmur, Jia Chen, Nina T. Holland, Dana Boyd Barr, Frederica P. Perera, and Mary S. Wolff | 1084

In Utero and Early-Life Exposure to Ambient Air Toxics and Childhood Brain Tumors: A Population-Based Case–Control Study in California, USA

Ondine S. von Ehrenstein, Julia E. Heck, Andrew S. Park, Myles Cockburn, Loraine Escobedo, and Beate Ritz | 1093

Ambient Temperature and the Risk of Preterm Birth in Guangzhou, China (2001–2011)

Jian-Rong He, Yu Liu, Xiao-Yan Xia, Wen-Jun Ma, Hua-Liang Lin, Hai-Dong Kan, Jin-Hua Lu, Qiong Feng, Wei-Jian Mo, Ping Wang, Hui-Min Xia, Xiu Qiu, and Louis J. Muglia | 1100

Prenatal Exposure to Phthalates and Anogenital Distance in Male Infants from a Low-Exposed Danish Cohort (2010–2012)

Tina Kold Jensen, Hanne Frederiksen, Henriette Boye Kyhl, Tina Harmer Lassen, Shanna H. Swan, Carl-Gustaf Bornehag, Niels E. Skakkebaek, Katharina M. Main, Dorte Vesterholm Lind, Steffen Husby, and Anna-Maria Andersson | 1107

Child Intelligence and Reductions in Water Arsenic and Manganese: A Two-Year Follow-up Study in Bangladesh

Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Pam Factor-Litvak, Jennie Kline, Abu B. Siddique, Hasan Shahriar, Mohammed Nasir Uddin, Alexander van Geen, Jacob L. Mey, Olgica Balac, and Joseph H. Graziano | 1114

Perspectives

Editorials

India Leads the Way: A ­Health-­Centered Strategy for Air Pollution

Ambuj Sagar, Kalpana Balakrishnan, Sarath Guttikunda, Anumita Roychowdhury, and Kirk R. Smith | A116

Brief Communications

Project TENDR: Targeting Environmental Neuro-Developmental Risks. The TENDR Consensus Statement

Deborah Bennett, David C. Bellinger, Linda S. Birnbaum, Asa Bradman, Aimin Chen, Deborah A. Cory-Slechta, Stephanie M. Engel, M. Daniele Fallin, Alycia Halladay, Russ Hauser, Irva Hertz-Picciotto, Carol F. Kwiatkowski, Bruce P. Lanphear, Emily Marquez, Melanie Marty, Jennifer McPartland, Craig J. Newschaffer, Devon Payne-Sturges, Heather B. Patisaul, Frederica P. Perera, Beate Ritz, Jennifer Sass, Susan L. Schantz, Thomas F. Webster, Robin M. Whyatt, Tracey J. Woodruff, R. Thomas Zoeller, Laura Anderko, Carla Campbell, Jeanne A. Conry, Nathaniel DeNicola, Robert M. Gould, Deborah Hirtz, Katie Huffling, Philip J. Landrigan, Arthur Lavin, Mark Miller, Mark A. Mitchell, Leslie Rubin, Ted Schettler, Ho Luong Tran, Annie Acosta, Charlotte Brody, Elise Miller, Pamela Miller, Maureen Swanson, and Nsedu Obot Witherspoon | A118

Errata

Erratum: “New Link in the Food Chain? Marine Plastic Pollution and Seafood Safety”

Nate Seltenrich | A123

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