Bisphenol A Exposure and Cardiac Electrical Conduction in Excised Rat Hearts
This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Posnack NG, Jaimes R III, Asfour H, Swift LM, Wengrowski AM, Sarvazyan N, Kay MW. Bisphenol A Exposure and Cardiac Electrical Conduction in Excised Rat Hearts. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1206157.
Received: 19 October 2012
Accepted: 29 January 2014
Advance Publication: 31 January 2014
For materials with complex tables, EHP offers “Alt 508″ versions optimized for use with screen-reading software.
Background: Bisphenol A (BPA) is used to produce polycarbonate plastics and epoxy resins that are widely used in everyday products, such as food and beverage containers, toys and medical devices. Human biomonitoring studies have suggested that a large proportion of the population may be exposed to BPA. Recent epidemiological studies have reported correlations between increased BPA urinary concentrations and cardiovascular disease; yet the direct effects of BPA on the heart are unknown.
Objectives: The goal of our studies was to measure BPA’s effect (0.1-100 μM) on cardiac impulse propagation ex vivo, using excised whole hearts from adult rats.
Methods: We measured atrial and ventricular activation times during sinus and paced rhythms using epicardial electrodes and optical mapping of transmembrane potential. Atrioventricular activation intervals and epicardial conduction velocities were computed using recorded activation times.
Results: Cardiac BPA exposure resulted in prolonged PR segment and decreased epicardial conduction velocity (0.1 – 100 μM), prolonged action potential duration (1 – 100 μM) and delayed atrioventricular conduction (10 – 100 μM). Importantly, these effects were observed after acute exposure (≤ 15 min), underscoring the potential detrimental effects of continuous BPA exposure. The highest BPA concentration used (100 μM) resulted in prolonged QRS intervals, dropped ventricular beats and eventually resulted in complete heart block.
Conclusions: Our results show that acute BPA exposure slows electrical conduction in excised hearts from female rats. These findings emphasize the importance of examining BPA’s effect on heart electrophysiology and determining whether chronic in vivo exposure can cause/exacerbate conduction abnormalities in patients with pre-existing heart conditions and other high-risk populations.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
- Ambient Air Pollution and Depressive Symptoms in Older Adults: Results from the MOBILIZE Boston Study
- The Human Early-Life Exposome (HELIX): Project Rationale and Design
- Epigenetic Influences on Associations between Air Pollutants and Lung Function in Elderly Men: The Normative Aging Study
- Associations between Traffic Noise, Particulate Air Pollution, Hypertension, and Isolated Systolic Hypertension in Adults: The KORA Study
- Estimating the Health Effects of Greenhouse Gas Mitigation Strategies: Addressing Parametric, Model, and Valuation Challenges
- Environmental Burden of Disease in Europe: Assessing Nine Risk Factors in Six Countries
- Non-Renal Effects and the Risk Assessment of Environmental Cadmium Exposure
- Trending EHP news this week: Chemicals in feminine hygiene products, personal lubricants http://t.co/RKLD6E7IKv
- Trending EHP research this week: Most plastic products release estrogenic chemicals http://t.co/YjnVQqflLu
- AdvPubl: Ambient air pollution and depressive symptoms in older adults: results from the MOBILIZE Boston study http://t.co/QJXO7WXjlM
- AdvPubl: The Human Early-Life Exposome (HELIX): project rationale and design http://t.co/T4UHBDeXvT
- CareerOpp: Tenure track non-clinical prof/assoc prof/asst/prof, environmental health, Sch Public Health, U Hong Kong http://t.co/9ZFkq4k4ST