News | Science Selection Volume 121 | Issue 10 | October 2013
Environ Health Perspect; DOI:10.1289/ehp.121-A311
Prenatal Protection: Maternal Diet May Modify Impact of PAHs
Julia R. Barrett, MS, ELS, a Madison, WI–based science writer and editor, has written for EHP since 1996. She is a member of the National Association of Science Writers and the Board of Editors in the Life Sciences.
Citation: Barrett JR. 2013. Prenatal protection: maternal diet may modify impact of PAHs. Environ Health Perspect 121:A311; http://dx.doi.org/10.1289/ehp.121-A311
Published: 1 October 2013
Related EHP Article
Prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) has previously been associated with higher incidence of depression, anxiety, and attention problems among highly exposed children.1,2 Although epidemiological studies have found clear associations between PAH exposure and adverse effects on fetal growth,3,4 evidence for impacts on growth has been inconsistent in biomarker-based research.5,6 A new study describes an association between prenatal PAH exposure and reduced birth weight that may be modified by mothers’ fruit and vegetable intake during pregnancy.7
PAHs are produced by incomplete combustion of diverse organic materials, including fossil fuels, tobacco, and foods.8 Once PAHs are inhaled or ingested, they are metabolized to compounds that can readily attach to DNA, forming so-called bulky DNA adducts that can set the stage for mutation and carcinogenesis.9 Bulky DNA adducts can be measured in cord blood as an indicator of a newborn’s prenatal exposure to several genotoxic agents, including PAHs.7
In the current study, the researchers used data collected for 612 newborns through the Newborns and Genotoxic Exposure Risks (NewGeneris) project, a multicenter European study investigating how contaminants in the diets of pregnant women affect their children’s health.10 The women were enrolled from 2006 to 2010 at 11 maternity units in Denmark, England, Greece, Norway, and Spain, and provided personal information and completed detailed food questionnaires. Birth information, including weight and head circumference, was gathered from medical records. Cord blood collected at birth was analyzed for levels of bulky DNA adducts at three laboratories in Hungary, Sweden, and the Netherlands.7
Bulky DNA adducts are not a specific biomarker but a broad biomarker, says coauthor Marie Pedersen, a postdoctoral researcher at the Centre for Research in Environmental Epidemiology in Barcelona, Spain. They are therefore well suited for studying complex exposures such as diet and traffic emissions. “I think that’s a strength for this study,” Pedersen says.
The researchers categorized adduct levels as low, moderate, or high and considered several statistical models for various birth outcomes and numerous confounding factors. Analyses were conducted for the entire study population, by country, and by groupings of southern (Greece and Spain) versus northern (England, Denmark, and Norway) countries.
For the entire study population, newborns in the high-adduct group had an average birth weight of 129 g less than newborns in the low-adduct group. The southern countries had, on average, higher adduct levels and lower birth weights than the northern group, but high adduct levels were associated with high, not low, birth weight. (Pedersen says the adducts in the south may reflect different exposures than those in the north, or there may have been some protective factor involved in the southern pregnancies.) In women with low intakes of fruits and vegetables, there was a stronger association between high adduct levels and low birth weight (an estimated 248-g reduction for high versus low adduct levels) than there was among women with high fruit and vegetable intakes (an estimated 58-g decrease for high versus low adduct levels).
Radim J. Šrám, head of the Department of Genetic Ecotoxicology at the Institute of Experimental Medicine AS CR in Czech Republic, who was not involved with the study, says of his own research on PAHs and human health, “According to our experience, you get better information about the quality of fruits and vegetables intake when you measure vitamin C and E in the plasma, than when you calculate it according to the answers in questionnaires.” Pedersen and her colleagues indicate that further study is needed to test and possibly expand on their findings. “I’m already doing the analysis for the next study, and I can see that there are many modifiable factors that we can work on,” says Pedersen.
1. Perera FP, et al. Polycyclic aromatic hydrocarbons–aromatic DNA adducts in cord blood and behavior scores in New York City children. Environ Health Perspect 119(8):1176–1181 (2011); http://dx.doi.org/10.1289/ehp.1002705.
2. Perera FP, et al. Prenatal polycyclic aromatic hydrocarbon (PAH) exposure and child behavior at age 6–7 years. Environ Health Perspect 120(6):921–926 (2012); http://dx.doi.org/10.1289/ehp.1104315.
3. Choi H, et al. Fetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restriction. PLoS ONE 7(4):e35464 (2012); http://dx.doi.org/10.1371/journal.pone.0035464.
4. Dejmek J, et al. The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome. Environ Health Perspect 108(12):1159–1164 (2000); http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240197/.
5. Jedrychowski WA, et al. The relationship between prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAH) and PAH–DNA adducts in cord blood. J Expo Sci Environ Epidemiol 23(4):371–377 (2013); http://dx.doi.org/10.1038/jes.2012.117.
6. Kelvin EA, et al. Modulation of the effect of prenatal PAH exposure on PAH–DNA adducts in cord blood by plasma antioxidants. Cancer Epidemiol Biomarkers Prev 18(8):2262–2268 (2009); http://dx.doi.org/10.1158/1055-9965.EPI-09-0316.
7. Pedersen M, et al. Bulky DNA adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother–child study (NewGeneris). Environ Health Perspect 121(10):1200–1206 (2013); http://dx.doi.org/10.1289/ehp.1206333.
8. EPA. Polycyclic Aromatic Hydrocarbons (PAHs) [fact sheet]. Washington, DC:Office of Solid Waste, U.S. Environmental Protection Agency (January 2008). Available: http://goo.gl/wgTfgz [accessed 16 September 2013].
9. Irigaray P, Belpomme D.. Basic properties and molecular mechanisms of exogenous chemical carcinogens. Carcinogenesis 31(2):135–148 (2010); http://dx.doi.org/10.1093/carcin/bgp252.
10. Merlo DF, et al. NewGeneris: a European study on maternal diet during pregnancy and child health. Cancer Epidemiol Biomarkers Prev 18(1):5–10 (2009); http://dx.doi.org/10.1158/1055-9965.EPI-08-0876.
CEHN December 2014 Article of the Month
“The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Integration of Animal and Human Evidence for PFOA Effects on Fetal Growth” (Environ Health Perspect; DOI:10.1289/ehp.1307923) has been selected by the Children’s Environmental Health Network (CEHN) as its December 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Introducing Children’s Health Collection 2014
EHP’s fifth annual Children’s Health Collection is now available. The collection comprises abstracts of all relevant articles published in EHP from October 2013 through September 2014: peer-reviewed research articles, news features, Science Selections, and editorials.
ISEE 2014 Abstracts Now Available
EHP is pleased to present the abstracts for the 26th annual conference of the International Society for Environmental Epidemiology (ISEE), From Local to Global: Advancing Science for Policy in Environmental Health, held 24–28 August 2014 in Seattle, Washington.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
Developmental Exposure to a Commercial PBDE Mixture: Effects on Protein Networks in the Cerebellum and Hippocampus of Rats
Attention Deficit/Hyperactivity Disorder and Childhood Autism in Association with Prenatal Exposure to Perfluoroalkyl Substances: A Nested Case–Control Study in the Danish National Birth Cohort
Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case–Control Analysis within the Nurses’ Health Study II Cohort
Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts
Interaction Effects of Temperature and Ozone on Lung Function and Markers of Systemic Inflammation, Coagulation, and Fibrinolysis: A Crossover Study of Healthy Young Volunteers