Phthalates and Childhood Asthma: Revealing an Association through Urinary Biomarkers
Tanya Tillett, MA, of Durham, NC, is a staff writer/editor for EHP. She has been on the EHP staff since 2000 and has represented the journal at national and international conferences.
Exposure to phthalates, substances used as plasticizers in a large number of consumer goods, can occur by ingestion, inhalation, or skin contact. Children—who are uniquely vulnerable to adverse health effects of environmental exposures because of their still-developing neurological, immunological, and respiratory systems—can receive particularly high exposures due to more frequent hand-to-mouth activity, combined with contact with polyvinyl chloride (PVC) surfaces and house dust, which collects phthalates (and other chemicals). Researchers now report an association between phthalate exposure and asthma and allergic disease in a cohort of 10-year-old Norwegian children [EHP 121(2):251–256; Bertelsen et al.].
The research team conducted a cross-sectional analysis of urine sample data from 623 children participating in the 10-year followup to the prospective Environment and Childhood Asthma study in Oslo. The followup included structured interviews with parents and blood tests, lung function tests, clinical examinations, and skin prick tests for allergic sensitization for children. Samples of first-morning urine were collected and assessed for three metabolites of low-molecular-weight phthalates (commonly used in personal care products) and eight metabolites of high-molecular-weight phthalates (commonly used in PVC applications such as flooring, electrical cords, car interiors, and older toys). The investigators used logistic regression modeling to estimate associations between current asthma and phthalate metabolite concentrations.
Previous animal studies have shown an association between high-molecular-weight phthalates and allergic disease development, while epidemiological studies have shown exposure to house dust containing several of these chemicals to be associated with asthma and allergic disease. The current analysis revealed an association between asthma in children and the highest quartiles of exposure to the metabolites mono-carboxyoctyl phthalate and mono-carboxynonyl phthalate. The parent compounds of these metabolites are high-molecular-weight phthalates used primarily as plasticizers in PVC items. No association was observed between asthma and the nine other metabolites, nor was any association detected between any metabolites and allergic sensitization.
Limitations of the study include the cross-sectional design and measurements based on single urine samples, which do not reflect phthalate exposures over time. However, the findings do support the growing body of evidence showing an association between asthma and exposure to high-molecular-weight phthalates.
The February 2013 News article “Phthalates and Childhood Asthma: Revealing an Association through Urinary Biomarkers” [Environ Health Perspect 121:A59 (2013)] referred to plastic/polyvinyl chloride toys as “phthalate-rich” in a discussion of phthalate exposures among 10-year-old Norwegian children. The Consumer Product Safety Improvement Act of 2008 and European Commission Decision C(1999) 4436 of 7 December 1999 eliminated or suspended the use of certain phthalates of concern in toys and children’s products. The children discussed in the News article were assessed in 2001–2004 and may have had access to toys purchased before the 1999 European ban. However, it was incorrect to suggest that all plastic toys continue to be “rich” sources of phthalates, and the article has been revised accordingly.
EHP regrets the error.
CEHN December 2014 Article of the Month
“The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Integration of Animal and Human Evidence for PFOA Effects on Fetal Growth” (Environ Health Perspect; DOI:10.1289/ehp.1307923) has been selected by the Children’s Environmental Health Network (CEHN) as its December 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Introducing Children’s Health Collection 2014
EHP’s fifth annual Children’s Health Collection is now available. The collection comprises abstracts of all relevant articles published in EHP from October 2013 through September 2014: peer-reviewed research articles, news features, Science Selections, and editorials.
ISEE 2014 Abstracts Now Available
EHP is pleased to present the abstracts for the 26th annual conference of the International Society for Environmental Epidemiology (ISEE), From Local to Global: Advancing Science for Policy in Environmental Health, held 24–28 August 2014 in Seattle, Washington.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
Developmental Exposure to a Commercial PBDE Mixture: Effects on Protein Networks in the Cerebellum and Hippocampus of Rats
Attention Deficit/Hyperactivity Disorder and Childhood Autism in Association with Prenatal Exposure to Perfluoroalkyl Substances: A Nested Case–Control Study in the Danish National Birth Cohort
Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case–Control Analysis within the Nurses’ Health Study II Cohort
Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts
Interaction Effects of Temperature and Ozone on Lung Function and Markers of Systemic Inflammation, Coagulation, and Fibrinolysis: A Crossover Study of Healthy Young Volunteers