News | Science Selection Volume 122 | Issue 4 | April 2014
Environ Health Perspect; DOI:10.1289/ehp.122-A111
Disease Burdens Associated with PM2.5 Exposure: How a New Model Provided Global Estimates
Carrie Arnold is a freelance science writer living in Virginia. Her work has appeared in Scientific American, Discover, New Scientist, Smithsonian, and more.
Citation: Arnold C. 2014. Disease burdens associated with PM2.5 exposure: how a new model provided global estimates. Environ Health Perspect 122:A111; http://dx.doi.org/10.1289/ehp.122-A111
News Topics: Air Pollution, Combustion Emissions, Exposure Science, Household Air Pollution, Indoor Air Quality, International Environmental Health, Particulate Matter (PM), Respiratory Health, Risk Assessment, Smoking and Secondhand Smoke (SHS)
Published: 1 April 2014
Related EHP Article
Like traffic jams and cell phones, particulate air pollution is a reality of modern living. Whether it’s from cigarette smoking, industrial emissions, or the burning of wood and dung for fuel, fine particulate matter (PM2.5) has been strongly linked to cardiovascular disease, inflammation, lung cancer, and other lung diseases.1,2 As part of the Global Burden of Disease Study (GBD) 2010 collaboration,3 an international team of environmental health scientists estimated the worldwide disease burden attributable to PM2.5 exposure.4 In this issue of EHP, they explain the underpinnings of how they did it.5
“This study is quite an important achievement,” says Robert Brook, a physician at the University of Michigan who was not involved with the research. “Currently, scientists have no other way to estimate these risks.”
In the past, risk models for PM2.5 and other air pollutants have been derived from work done almost exclusively in North America and Europe. But air pollution levels around the world vary widely—by one estimate, annual average PM2.5 concentrations in the United States top out at 20–40 µg/m3 (in Texas), compared with 80–130 µg/m3 in parts of China and India.6
Estimating the health risks of PM2.5 in developing countries, where few primary epidemiological studies have been conducted, has therefore required extrapolation to higher concentrations of air pollutants.7 Further complicating matters is evidence that the relationship between mortality risk and PM2.5 exposure is not linear, meaning risk appears to increase more rapidly at lower exposures than at higher ones.8,9
The GBD 2010 team incorporated information about the health risks of PM2.5 from ambient air pollution, active smoking, secondhand smoke, and indoor burning of solid fuels into an integrated exposure–response model. The amounts of pollution caused by smoking, secondhand smoke, and indoor fuel use are well documented, as are the resulting health problems.10,8,11
The researchers combined this knowledge with what is known about different concentrations of ambient air pollution around the world to estimate relative risks of dying from a variety of illnesses, including ischemic heart disease, cerebrovascular disease (stroke), chronic obstructive pulmonary disease, and lung cancer over a range of ambient PM2.5 exposures from very low to very high. The model also estimates years of healthy life lost due to PM2.5-related acute lower respiratory illnesses in children under the age of 5 years.5
“We integrated as much information on exposure to particulate matter and mortality from as many different sources as we possibly could,” says lead author Richard Burnett, an environmental scientist at Health Canada. “Because some of these exposures had very high concentrations, we could build a risk model over the entire global range of potential exposures.”
The risk curves for different illnesses were not identical. Whereas the estimated risk of lung cancer and child acute lower respiratory illness appeared to continually increase along with increasing concentrations of PM2.5, the curves for heart disease and stroke rapidly increased at lower concentrations of PM2.5 before leveling off.5
One of the major advantages of the model is that it can be updated easily, yielding estimates of risk that reflect the latest knowledge. The major limitation of the study is that the researchers assumed the health risks of different types of PM2.5 were the same, says Michael Jerrett, a professor of environmental health sciences at the University of California, Berkeley, who was not involved with the study.
PM2.5 is a mixture of many constituents that can vary, depending on the source and the season.12 “There is considerable evidence that some elements of the mixture are less toxic than others,” Jerrett says. “However, to try to untangle that and come up with definitive estimates for sulfate versus nitrate versus black carbon would go beyond the capacity of our current scientific evidence to determine accurately.” He concludes, “It’s a mathematically elegant model that is a major advance over what has been done in the past. It represents the best that we can do with the available information.”
1. Loomis D, et al. The carcinogenicity of outdoor air pollution. Lancet Oncol 14(13):1262–1263 (2013); http://dx.doi.org/10.1016/S1470-2045(13)70487-X.
2. EPA. Integrated Science Assessment for Particulate Matter. EPA/600/R-08/139F. Research Triangle Park, NC:U.S. Environmental Protection Agency (2009). Available: http://www.epa.gov/ncea/pdfs/partmatt/Dec2009/PM_ISA_full.pdf [accessed 17 March 2014].
3. IHME. Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010) [website]. Seattle, WA:Institute for Health Metrics and Evaluation (2014). Available: http://goo.gl/dg5AaC [accessed 17 March 2014].
4. Lim SS, et al. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2224–2260 (2012); http://dx.doi.org/10.1016/S0140-6736(12)61766-8.
5. Burnett RT, et al. An integrated risk function for estimating the global burden of disease attributable to ambient fine particulate matter exposure. Environ Health Perspect 122(4):397–403 (2014); http://dx.doi.org/10.1289/ehp.1307049.
6. Brauer M, et al. Exposure assessment for estimation of the global burden of disease attributable to outdoor air pollution. Environ Sci Technol 46(2):652–660 (2012); http://dx.doi.org/10.1021/es2025752.
7. Cohen AJ, et al. Urban air pollution. In: Comparative Quantification of Health Risks: Global and Regional Burden of Disease Attribution to Selected Major Risk Factors (Ezzati M, et al., eds.). Geneva, Switzerland:World Health Organization (2004). Available: http://www.who.int/publications/cra/chapters/volume2/1353-1434.pdf [accessed 17 March 2014].
8. Pope CA III, et al. Cardiovascular mortality and exposure to fine particulate matter from air pollution and cigarette smoke: shape of the exposure–response relationship. Circulation 120(11):941–948 (2009); http://dx.doi.org/10.1161/CIRCULATIONAHA.109.857888.
9. Pope CA III, et al. Lung cancer and cardiovascular disease mortality associated with particulate matter exposure from ambient air pollution and cigarette smoke: shape of the exposure–response relationships. Environ Health Perspect 119(11):1616–1621 (2011); http://dx.doi.org/10.1289/ehp.1103639.
10. Invernizzi G, et al. Particulate matter from tobacco versus diesel car exhaust: an educational perspective. Tob Control 13(3):219–221 (2004); http://dx.doi.org/10.1136/tc.2003.005975.
11. Kleeman MJ, et al. Size and composition distribution of fine particulate matter emitted from wood burning, meat charbroiling, and cigarettes. Environ Sci Technol 33(20):3516–3523 (1999); http://dx.doi.org/10.1021/es981277q.
12. Bell ML, et al. Spatial and temporal variation in PM2.5 chemical composition in the United States for health effects studies. Environ Health Perspect 115(7):989–995 (2007); http://dx.doi.org/10.1289/ehp.9621.
CEHN September 2014 Article of the Month“Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study” (Environ Health Perspect; DOI:10.1289/ehp.1307562) has been selected by the Children’s Environmental Health Network (CEHN) as its September 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Register Today for PPTOX IVEnvironmental Stressors in Disease and Implications for Human Health
October 26–29, 2014
Boston Marriott Long Wharf Hotel
Join the Endocrine Society for the fourth international summit of Prenatal Programming and Toxicity (PPTOX), a premiere conference series dedicated to cutting-edge discussion of environmental hazards during early life and long-term consequences.* Housing deadline: Monday, October 6
For more information, visit the Endocrine Society website.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
- Comparative Assessment of the Effects of Climate Change on Heat- and Cold-Related Mortality in the United Kingdom and Australia
- Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania
- Green and Blue Spaces and Behavioral Development in Barcelona Schoolchildren: The BREATHE Project
- Aerial Application of Mancozeb and Urinary Ethylene Thiourea (ETU) Concentrations among Pregnant Women in Costa Rica: The Infants’ Environmental Health Study (ISA)
- Pyrethroid Pesticide Exposure and Parental Report of Learning Disability and Attention Deficit/Hyperactivity Disorder in U.S. Children: NHANES 1999–2002
- Household Cooking with Solid Fuels Contributes to Ambient PM2.5 Air Pollution and the Burden of Disease
- Effect of Exposure to Atmospheric Ultrafine Particles on Production of Free Fatty Acids and Lipid Metabolites in the Mouse Small Intestine
- Trending EHP news this week: Vaping and health: what do we know about e-cigarettes? http://t.co/p3MM6LOuVB
- Trending EHP research this week: Proximity to gas wells and reported health status http://t.co/VP5yPtd8Zx
- EHPNoonNews: Diverse gut bacteria associated with favorable ratio of estrogen metabolites http://t.co/CqQ38cZyjK @newswise
- EHPNoonNews: Canada bans citronella pesticides http://t.co/M0TDFhVLPL @twitcoast
- EHPNoonNews: CDC funds NH efforts to monitor prevalence of environmental chemicals http://t.co/dVjlETral3 @conmonitornews