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News | Science Selections January 2014 | Volume 122 | Issue 1

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Environ Health Perspect; DOI:10.1289/ehp.122-A29

Toxicity beyond the Lung: Connecting PM2.5, Inflammation, and Diabetes

Carol Potera, based in Montana, has written for EHP since 1996. She also writes for Microbe, Genetic Engineering News, and the American Journal of Nursing.

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Citation: Potera C. 2014. Toxicity beyond the lung: connecting PM2.5, inflammation, and diabetes. Environ Health Perspect 122:A29; http://dx.doi.org/10.1289/ehp.122-A29

News Topics: Combustion Emissions, Endocrine Health, Inflammation, Molecular Biology, Obesity, Particulate Matter (PM)

Published: 1 January 2014

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Related EHP Article

Air Pollution–Mediated Susceptibility to Inflammation and Insulin Resistance: Influence of CCR2 Pathways in Mice

Cuiqing Liu, Xiaohua Xu, Yuntao Bai, Tse-Yao Wang, Xiaoquan Rao, Aixia Wang, Lixian Sun, Zhekang Ying, Liubov Gushchina, Andrei Maiseyeu, Masako Morishita, Qinghua Sun, Jack R. Harkema, and Sanjay Rajagopalan

Exposure to fine particulate matter (PM2.5) has been associated with increased risk of heart disease,1 insulin resistance (IR),2 and diabetes,3 all conditions that are characterized by inflammation.4 Experimental data suggest a high-fat diet2 may exacerbate the health effects of inhaled PM2.5; obese people also appear to be at increased risk.1 In this issue of EHP, investigators tease out some of the complex cellular mechanisms that could explain how PM2.5 may work with a high-fat diet to cause IR.5

Some of the authors previously reported that mice breathing PM2.5 and eating a high-fat diet developed IR, systemic inflammation, and increased abdominal fat, compared with mice eating the same diet but breathing filtered air.2 For the current study, the investigators focused on CCR2, a protein that recruits innate immune cells to insulin-sensitive tissues such as visceral fat and the liver, where it induces the inflammation characteristically seen in animal models of obesity and type 2 diabetes.6 They compared wild-type mice that produce CCR2 with “knockout” (CCR2–/–) mice that don’t. All the mice were fed a high-fat diet and then for 17 weeks were exposed to either filtered air or air containing 117 µg/m3 of PM2.5.

Among the key findings, PM2.5 exposure was associated with increased IR and increased levels of liver lipids in the wild-type mice. The elevated liver lipids resulted from a rise in SREBP-1c activity5; this protein helps regulate fatty acid synthesis.7 In contrast, liver lipid levels and SREBP-1c activity in CCR2–/– mice were equivalent whether the mice were exposed to PM2.5 or breathing filtered air.5

IR is also characterized by abnormal insulin signaling through the AKT pathway. Reduced phosphorylation of this enzyme is associated with inflammation.8 The researchers found that phosphorylation of AKT was reduced in wild-type mice exposed to PM2.5 but unchanged in CCR2–/– mice. PM2.5 exposure also was associated with higher levels of inflammatory F4/80 macrophages in visceral fat stores, but only in wild-type mice.5

The important message in all these findings is that PM2.5 recruits inflammatory cells via CCR2-dependent mechanisms. “This mechanism directly ties a known inflammatory mechanism in the pathogenesis of type 2 diabetes to exposure to environmental air pollution,” says study leader Sanjay Rajagopalan, division head for cardiology at the University of Maryland Medical Center.

CCR2 protein structureThe protein CCR2 is involved in the inflammation that characterizes animal models of obesity and type 2 diabetes. Pleiotrope/Public Domain

Rajagopalan says the inflammatory damage likely creates a vicious cycle that can also contribute to cardiovascular disease and obesity. “We should look more closely at these kinds of associations in human epidemiological studies,” he says.

PM2.5 is generated by vehicle exhaust, burning wood and coal, and industrial processes.9 Annual PM2.5 levels in cities in China, India, and Latin America can average 100–150 µg/m3, comparable to the PM2.5 exposure in this study.2

“It’s long been suspected that the immune system played a major role in ‘carrying’ the toxicity of air pollutants beyond the lung,” says Matthew Campen, an associate professor at the University of New Mexico College of Pharmacy, who was not involved in the study.

The results by Rajagopalan’s team strongly support the role of the innate immune system in mediating PM2.5 toxicity in tissues far from the lung. The results, Campen says, also suggest that PM2.5 pollution could worsen cardiometabolic syndromes brought on by an unhealthy diet and lifestyle. “This public health burden may be offset by anti-inflammatory drugs or healthy diets,” he says. Alternatively, Rajagopalan proposes, “A practical solution would be to lower levels of PM2.5.” As Campen wryly points out, “These differing approaches may reflect the backgrounds of an environmental health scientist who understands the challenges entailed in further reductions in air pollution levels, compared with a cardiologist who understands how difficult it is to change human behavior.”


References

1. Miller KA, et al. Long-term exposure to air pollution and incidence of cardiovascular events in women. N Engl J Med 356(5):447–458 (2007); http://dx.doi.org/10.1056/NEJMoa054409. 2. Sun Q, et al. Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity. Circulation 119(4):538–546 (2009); http://dx.doi.org/10.1161/CIRCULATIONAHA​.108.799015. 3. Pearson JF, et al. Association between fine particulate matter and diabetes prevalence in the U.S. Diabetes Care 33(10):2196–2201 (2010); http://dx.doi.org/10.2337/dc10-0698. 4. O’Neill MS, et al. Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility. Occup Environ Med 64(6):373–379 (2007); http://dx.doi.org/10.1136/oem.2006.03002​3. 5. Liu C, et al. Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice. Environ Health Perspect 122(1):17–26 (2014); http://dx.doi.org/10.1289/ehp.1306841. 6. Weisberg SP, et al. CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116(1):115–124 (2006); http://dx.doi.org/10.1172/JCI24335. 7. Kato T, et al. Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell Metab 4(2):143–154 (2006); http://dx.doi.org/10.1016/j.cmet.2006.06​.009. 8. Shao J, et al. Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice. J Endocrinol 167(1):107–115 (2000); http://dx.doi.org/10.1677/joe.0.1670107. 9. Bhatnagar A. Could dirty air cause diabetes? Circulation 119(4):492–494 (2009); http://dx.doi.org/10.1161/CIRCULATIONAHA​.108.831404.



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