Children's Health Advance Publication
Perfluoroalkyl Chemicals and Asthma among Children 12–19 Years of Age: NHANES (1999–2008)
This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Humblet O, Diaz-Ramirez LG, Balmes JR, Pinney SM, Hiatt RA. Perfluoroalkyl Chemicals and Asthma among Children 12–19 Years of Age: NHANES (1999–2008). Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1306606.
Received: 4 February 2013
Accepted: 5 June 2014
Advance Publication: 6 June 2014
For materials with complex tables, EHP offers “Alt 508″ versions optimized for use with screen-reading software.
Background: Perfluoroalkyl chemicals (PFCs) are a family of commonly-used industrial chemicals whose persistence and ubiquity in human blood samples has led to concern about possible toxicity. Several animal studies and one recent human study have suggested a link between exposure to PFCs and asthma, although few epidemiologic studies have been conducted.
Methods: We evaluated the association between serum concentrations of eight PFCs, including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS), with self-reported lifetime asthma, recent wheezing, and current asthma using data from participants 12-19 years of age from the 1999-2000 and 2003-2008 National Health and Nutrition Examination Surveys.
Results: In multivariable adjusted models, PFOA was associated with higher odds of ever having received a diagnosis of asthma (OR: 1.18, 95% CI: 1.01, 1.39 for a doubling in PFOA), whereas for PFOS there were inverse relationships with both asthma and wheezing (OR: 0.88, 95% CI: 0.74, 1.04; OR: 0.83, 95% CI: 0.67, 1.02, respectively). The associations were attenuated after accounting for sampling weights. No associations were seen between the other PFCs and any outcome.
Conclusions: This cross-sectional study provides some evidence for associations between exposure to PFCs and asthma-related outcomes in children. The evidence is inconsistent, however, and prospective studies are needed.
New Search FunctionWe're pleased to present our improved search page. Try it, and let us know what you think!
CEHN September 2014 Article of the Month“Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study” (Environ Health Perspect; DOI:10.1289/ehp.1307562) has been selected by the Children’s Environmental Health Network (CEHN) as its September 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Register Today for PPTOX IVEnvironmental Stressors in Disease and Implications for Human Health
October 26–29, 2014
Boston Marriott Long Wharf Hotel
Join the Endocrine Society for the fourth international summit of Prenatal Programming and Toxicity (PPTOX), a premiere conference series dedicated to cutting-edge discussion of environmental hazards during early life and long-term consequences.* Housing deadline: Monday, October 6
For more information, visit the Endocrine Society website.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
Asthma in Inner-City Children at 5-11 Years of Age and Prenatal Exposure to Phthalates: The Columbia Center for Children’s Environmental Health Cohort
Comparative Assessment of the Effects of Climate Change on Heat- and Cold-Related Mortality in the United Kingdom and Australia
Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania
Green and Blue Spaces and Behavioral Development in Barcelona Schoolchildren: The BREATHE Project
Aerial Application of Mancozeb and Urinary Ethylene Thiourea (ETU) Concentrations among Pregnant Women in Costa Rica: The Infants’ Environmental Health Study (ISA)
Pyrethroid Pesticide Exposure and Parental Report of Learning Disability and Attention Deficit/Hyperactivity Disorder in U.S. Children: NHANES 1999–2002
Household Cooking with Solid Fuels Contributes to Ambient PM2.5 Air Pollution and the Burden of Disease
- Trending EHP news this week: Environmental influences on the aging brain http://t.co/6Z1aXYDwl8
- Trending EHP research this week: Proximity to natural gas wells and reported health status http://t.co/5YR4420qsI
- EHPNoonNews: When the snows fail http://t.co/OaLdfVzGwm @natgeo
- EHPNoonNews: Too few university jobs for America's young scientists http://t.co/gsM9Nkja53 @npr
- EHPNoonNews: Second container possibly leaked at NM nuclear waste site http://t.co/amGeGgQ8ok @reuters