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Children's Health Advance Publication

Environ Health Perspect; DOI:10.1289/ehp.1306758

Gestational Weight Gain and Exposure of Newborns to Persistent Organic Pollutants

Esther Vizcaino,1,2,3 Joan O. Grimalt,2 Berit Glomstad,2 Ana Fernández-Somoano,1,3 and Adonina Tardón1,3
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1Department of Preventive Medicine and Public Health, University of Oviedo, Asturias, Spain; 2Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Barcelona, Catalonia, Spain; 3Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain
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This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.

Citation: Vizcaino E, Grimalt JO, Glomstad B, Fernández-Somoano A, Tardón A. Gestational Weight Gain and Exposure of Newborns to Persistent Organic Pollutants. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1306758.

Received: 5 March 2013
Accepted: 1 May 2014
Advance Publication: 2 May 2014

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Abstract

Background: Exposure to persistent organic pollutants (POPs) during fetal development can increase the risk of adverse health effects during childhood. Maternal characteristics and physiological changes during gestation such as gestational weight gain (GWG) may have an influence in the overall burden of POPs in neonates. However, the associations between GWG and POP concentrations are still not well established.

Objective: We examined the association of GWG with cord serum POPs concentrations after adjusting for pre-pregnancy maternal body mass index (BMI) and other potential determinants of the transfer of POPs into newborns. The GWG values were evaluated after grouping by the reference guidelines of the Institute of Medicine (IOM).

Methods: We measured levels of 14 organochlorine pesticides, 7 polychlorobiphenyls (PCBs) and 14 polybromodiphenyl ethers (PBDEs) in 325 cord serum samples from a Spanish birth cohort. Multivariable models were used to estimate associations of GWG, pre-pregnancy BMI, and other maternal determinants on cord serum concentrations of POPs.

Results: Neonatal concentrations of POPs were inversely associated with GWG after adjustment for age, pre-pregnancy BMI, educational level, and fish consumption. On average, neonates of women with IOM recommended GWG have lower POP concentrations than neonates of mothers with inadequate GWG.

Conclusions: The present findings suggest an association between neonatal exposure to POPs and inadequate GWG during pregnancy. Encouraging pregnant women to meet the recommended IOM guidelines for GWG may reduce the accumulation of POPs in newborns.


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