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Children's Health Advance Publication

Environ Health Perspect; DOI:10.1289/ehp.1307473

Prenatal and Postnatal Serum PCB Concentrations and Cochlear Function in Children at 45 Months of Age

Todd A. Jusko,1 Renata Sisto,2 Ana-Maria Iosif,3 Arturo Moleti,4 Soňa Wimmerová,5 Kinga Lancz,5 Juraj Tihányi,5 Eva Šovčíková,5 Beata Drobná,5 Ľubica Palkovičová,5 Dana Jurečková,6 Kelly Thevenet-Morrison,1 Marc-André Verner,7,8 Dean Sonneborn,9 Irva Hertz-Picciotto,9 and Tomáš Trnovec
Author Affiliations close
1Division of Epidemiology, Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA; 2Department of Occupational Hygiene, INAIL, Monte Porzio Catone, Italy; 3Division of Biostatistics, Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, California, USA; 4Department of Physics, University of Rome Tor Vergata, Rome, Italy; 5Slovak Medical University, Bratislava, Slovakia; 6The Štefan Kukura Hospital and Policlinic, Michalovce, Slovakia; 7Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA; 8Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden; 9Division of Environmental and Occupational Health, Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, California, USA
About This Article open

This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.

Citation: Jusko TA, Sisto R, Iosif AM, Moleti A, Wimmerová S, Lancz K, Tihányi J, Šovčíková E, Drobná B, Palkovičová L, Jurečková D, Thevenet-Morrison K, Verner MA, Sonneborn D, Hertz-Picciotto I, Trnovec T. Prenatal and Postnatal Serum PCB Concentrations and Cochlear Function in Children at 45 Months of Age. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1307473.

Received: 6 August 2013
Accepted: 21 July 2014
Advance Publication: 22 July 2014

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Abstract

Background: Some experimental and human data suggest that exposure to PCBs may induce ototoxicity, though results of previous epidemiologic studies are mixed, and generally focus on either prenatal or postnatal PCB concentrations exclusively.

Objectives: Our aim was to evaluate the association between pre- and postnatal PCB concentrations in relation to cochlear status assessed by distortion product otoacoustic emissions, and to further clarify the critical periods in development where cochlear status may be most susceptible to PCBs.

Methods: A total of 351 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at age 45 months. Maternal pregnancy, cord, and child 6-, 16-, and 45-month blood samples were collected and analyzed for PCB concentrations. At 45 months of age, distortion product otoacoustic emissions (DPOAEs) were assessed at 11 frequencies in both ears. Multivariate, generalized linear models were used to estimate the associations between PCB concentrations at different ages and DPOAEs, adjusting for potential confounders.

Results: Maternal and cord PCB-153 concentrations were not associated with DPOAEs at 45 months. Higher postnatal PCB concentrations at 6-, 16-, and 45-months of age were associated with lower (poorer) DPOAE amplitudes. When all postnatal PCB exposures were considered as an area under the curve metric, an increase in PCB-153 concentration from the 25th to the 75th percentile was associated with a 1.6 db SPL decrease in DPOAE amplitude (95% CI = -2.6, -0.5; p = 0.003).

Conclusions: In this study, postnatal, rather than maternal or cord PCB concentrations were associated with poorer performance on otoacoustic tests at age 45 months.


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