Children's Health Advance Publication
Prenatal and Postnatal Serum PCB Concentrations and Cochlear Function in Children at 45 Months of Age
This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Jusko TA, Sisto R, Iosif AM, Moleti A, Wimmerová S, Lancz K, Tihányi J, Šovčíková E, Drobná B, Palkovičová L, Jurečková D, Thevenet-Morrison K, Verner MA, Sonneborn D, Hertz-Picciotto I, Trnovec T. Prenatal and Postnatal Serum PCB Concentrations and Cochlear Function in Children at 45 Months of Age. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1307473.
Received: 6 August 2013
Accepted: 21 July 2014
Advance Publication: 22 July 2014
PDF Version (858 KB)
Background: Some experimental and human data suggest that exposure to PCBs may induce ototoxicity, though results of previous epidemiologic studies are mixed, and generally focus on either prenatal or postnatal PCB concentrations exclusively.
Objectives: Our aim was to evaluate the association between pre- and postnatal PCB concentrations in relation to cochlear status assessed by distortion product otoacoustic emissions, and to further clarify the critical periods in development where cochlear status may be most susceptible to PCBs.
Methods: A total of 351 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at age 45 months. Maternal pregnancy, cord, and child 6-, 16-, and 45-month blood samples were collected and analyzed for PCB concentrations. At 45 months of age, distortion product otoacoustic emissions (DPOAEs) were assessed at 11 frequencies in both ears. Multivariate, generalized linear models were used to estimate the associations between PCB concentrations at different ages and DPOAEs, adjusting for potential confounders.
Results: Maternal and cord PCB-153 concentrations were not associated with DPOAEs at 45 months. Higher postnatal PCB concentrations at 6-, 16-, and 45-months of age were associated with lower (poorer) DPOAE amplitudes. When all postnatal PCB exposures were considered as an area under the curve metric, an increase in PCB-153 concentration from the 25th to the 75th percentile was associated with a 1.6 db SPL decrease in DPOAE amplitude (95% CI = -2.6, -0.5; p = 0.003).
Conclusions: In this study, postnatal, rather than maternal or cord PCB concentrations were associated with poorer performance on otoacoustic tests at age 45 months.
New Search FunctionWe're pleased to present our improved search page. Try it, and let us know what you think!
CEHN October 2014 Article of the Month“Maternal Exposure to Criteria Air Pollutants and Congenital Heart Defects in Offspring: Results from the National Birth Defects Prevention Study” (Environ Health Perspect; DOI:10.1289/ehp.1307289) has been selected by the Children’s Environmental Health Network (CEHN) as its October 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Register Today for PPTOX IVEnvironmental Stressors in Disease and Implications for Human Health
October 26–29, 2014
Boston Marriott Long Wharf Hotel
Join the Endocrine Society for the fourth international summit of Prenatal Programming and Toxicity (PPTOX), a premiere conference series dedicated to cutting-edge discussion of environmental hazards during early life and long-term consequences.* Housing deadline: Monday, October 6
For more information, visit the Endocrine Society website.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
Structural and Functional Profiling of Environmental Ligands for Estrogen Receptors
Neurobehavioral Function in School-Age Children Exposed to Manganese in Drinking Water
Modeled PFOA Exposure and Coronary Artery Disease, Hypertension, and High Cholesterol in Community and Worker Cohorts
Characteristics of Walkable Built Environments and BMI z-Scores in Children: Evidence from a Large Electronic Health Record Database
Comparative Assessment of the Effects of Climate Change on Heat- and Cold-Related Mortality in the United Kingdom and Australia