Editorial Volume 121 | Issue 11-12 | Nov-Dec 2013
Environ Health Perspect; DOI:10.1289/ehp.1307850
EHP Paper of the Year, 2013
Hugh A. Tilson
Editor-in-Chief, Environmental Health Perspectives, firstname.lastname@example.org
Citation: Tilson HA. 2013. EHP paper of the year, 2013 [Editorial]. Environ Health Perspect 121:A322; http://dx.doi.org/10.1289/ehp.1307850
Published: 1 December 2013
Environmental Health Perspectives (EHP) established the Paper of the Year Award in 2008 to recognize high-quality papers published in the journal (Tilson 2008). Starting in 2011, EHP decided to recognize two papers each year (Tilson 2011). The EHP Classic Paper of the Year is the research article, commentary, or review that is the most highly cited over the preceding 60 months. The winner of the 2013 EHP Classic Paper of the Year, announced in September (Tilson 2013), was “Effects of Particulate Matter on Genomic DNA Methylation Content and iNOS Promoter Methylation” by Letizia Tarantini, Matteo Bonzini, Pietro Apostoli, Valeria Pegoraro, Valentina Bollati, Barbara Marinelli, Laura Cantone, Giovanna Rizzo, Lifang Hou, Joel Schwartz, Pier Alberto Bertazzi, and Andrea Baccarelli (Tarantini et al. 2009).
The second paper to be recognized each year is the EHP Paper of the Year. This award recognizes the most highly cited paper published during the preceding year. EHP is pleased to announce that the 2013 Paper of the Year is “450K Epigenome-Wide Scan Identifies Differential DNA Methylation in Newborns Related to Maternal Smoking during Pregnancy” by Bonnie R. Joubert, Siri E. Håberg, Roy M. Nilsen, Xuting Wang, Stein E. Vollset, Susan K. Murphy, Zhiqing Huang, Cathrine Hoyo, Øivind Midttun, Lea A. Cupul-Uicab, Per M. Ueland, Michael C. Wu, Wenche Nystad, Douglas A. Bell, Shyamal D. Peddada, and Stephanie J. London (Joubert et al. 2012). This paper was published in the October 2012 issue of the journal.
It is well known that children whose mothers smoked during pregnancy are more likely to have health problems such as low birth weight and asthma. Joubert et al. addressed the hypothesis that the diverse effects of maternal smoking during pregnancy may involve epigenetic modifications such as DNA methylation. The investigators obtained cord blood samples from a pregnancy cohort in the Norwegian Mother and Child Study (MoBa), and they used the Illumina Methyl450K platform to examine whether methylation changes were associated with smoking during pregnancy. Joubert et al. found cord blood methylation of genes in a pathway important for the detoxification of chemicals in tobacco smoke. They also identified the methylation of novel genes not previously implicated in the response to tobacco smoke, one of which is involved in fundamental developmental processes. Work is now in progress to a) determine whether these changes persist in children at 7 years of age, b) examine the role of timing of exposure, and c) explore whether epigenetic inheritance plays a role in these findings. The authors are also coordinating an effort to bring together studies with data from the same platform for a meta-analysis of the effects of maternal smoking on newborns. The findings of Joubert et al. support the possibility that epigenetic mechanisms seen by DNA methylation may be associated with effects of maternal smoking during pregnancy.
EHP congratulates all the authors of this paper for their contribution to the environmental health science literature. This research is important because it demonstrates the value of using this approach to study mechanisms of epigenetic effects of in utero exposures to chemicals and other environmental factors.
Joubert BR, Håberg SE, Nilsen RM, Wang X, Vollset SE, Murphy SK, et al. 2012. 450K Epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect 120:1425–1431; doi:10.1289/ehp.1205412.
Tarantini L, Bonzini M, Apostoli P, Pegoraro V, Bollati V, Marinelli B, et al. 2009. Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect 117:217–222; doi:10.1289/ehp.11898.
Tilson HA. 2008. EHP papers of the year, 2008 [Editorial]. Environ Health Perspect 116:A234; doi:10.1289/ehp.11684.
Tilson HA. 2011. EHP classic paper of the year, 2011 [Editorial]. Environ Health Perspect 119:A238; doi:10.1289/ehp.1103844.
Tilson HA. 2013. EHP classic paper of the year, 2013 [Editorial]. Environ Health Perspect 121:A266; doi:10.1289/ehp.1307395.
Upcoming Recruitment: Editor-in-Chief for Environmental Health Perspectives
The National Institute of Environmental Health Sciences (NIEHS) will soon commence searching for the next Editor-in-Chief of Environmental Health Perspectives. For more information visit our Careers and Funding page.
CEHN March 2015 Article of the Month
“Maternal Arsenic Exposure, Arsenic Methylation Efficiency, and Birth Outcomes in the Biomarkers of Exposure to ARsenic (BEAR) Pregnancy Cohort in Mexico” (Environ Health Perspect; DOI:10.1289/ehp.1307476) has been selected by the Children’s Environmental Health Network (CEHN) as its March 2015 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
Anthropometry in 5- to 9-Year-Old Greenlandic and Ukrainian Children in Relation to Prenatal Exposure to Perfluorinated Alkyl Substances
Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients
Obesogens beyond Vertebrates: Lipid Perturbation by Tributyltin in the Crustacean Daphnia magna
Space–Time Covariation of Mortality with Temperature: A Systematic Study of Deaths in France, 1968–2009
Epidemiology and Ecology of Opportunistic Premise Plumbing Pathogens: Legionella pneumophila, Mycobacterium avium, and Pseudomonas aeruginosa