Review Advance Publication
The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Integration of Animal and Human Evidence for PFOA Effects on Fetal Growth
This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Lam J, Koustas E, Sutton P, Johnson PI, Atchley DS, Sen S, Robinson KA, Axelrad DA, Woodruff TJ. The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Integration of Animal and Human Evidence for PFOA Effects on Fetal Growth. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1307923.
Received: 22 November 2013
Accepted: 20 June 2014
Advance Publication: 25 June 2014
For materials with complex tables, EHP offers “Alt 508″ versions optimized for use with screen-reading software.
Background: The Navigation Guide is a novel systematic review method to synthesize scientific evidence and reach strength-of-evidence conclusions for environmental health decision-making.
Objective: Integrate scientific findings from human and non-human studies to determine the overall strength of evidence for the question: “Does developmental exposure to perfluorooctanoic acid (PFOA) affect fetal growth in humans?”
Methods: We developed and applied a priori criteria to systematically and transparently: (1) rate the quality of the scientific evidence as ‘high,’ ‘moderate’ or ‘low’; (2) rate the strength of the human and non-human evidence separately as: ‘sufficient,’ ‘limited,’ ‘moderate,’ or ‘evidence of lack of toxicity’; and (3) integrate the strength of the human and non-human evidence ratings into a strength of the evidence conclusion.
Results: We identified 18 epidemiology and 21 animal toxicology studies relevant to our study question. We rated both the human and non-human mammalian evidence as ‘moderate’ quality and ‘sufficient’ strength. Integration of these evidence ratings produced a final strength of evidence rating where review authors concluded that PFOA is ‘known to be toxic’ to human reproduction and development based on sufficient evidence of decreased fetal growth in both human and non-human mammalian species.
Conclusion: The authors of this review concluded that developmental exposure to PFOA adversely affects human health based on sufficient evidence of decreased fetal growth in both human and non-human mammalian species. The results of this case study demonstrated the application of a systematic and transparent methodology, via the Navigation Guide, for reaching strength of evidence conclusions in environmental health.
New Impact Factor
We are pleased to announce our new impact factor of 7.03 and—for the first time—our inclusion in the category of Toxicology. Thank you to our authors and readers, who continue to make EHP a leading journal in Environmental Sciences, in Public, Environmental, and Occupational Health, and now in Toxicology.
EHP News Feature Wins Award
Our March 2013 cover story, “A Tale of Two Forests: Addressing Postnuclear Radiation at Chernobyl and Fukushima,” has won first place in the Outstanding Feature Story category of the Society of Environmental Journalists Awards for Reporting on the Environment. The judges called the story “an exceedingly vital and original piece of environmental feature writing.” Congratulations to authors Winifred A. Bird and Jane Braxton Little on their exciting achievement!
CEHN August 2014 Article of the Month
“Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study” (Environ Health Perspect; DOI:10.1289/ehp.1307261) has been selected by the Children’s Environmental Health Network (CEHN) as its August 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Register Today for PPTOX IVEnvironmental Stressors in Disease and Implications for Human Health
October 26–29, 2014
Boston Marriott Long Wharf Hotel
Join the Endocrine Society for the fourth international summit of Prenatal Programming and Toxicity (PPTOX), a premiere conference series dedicated to cutting-edge discussion of environmental hazards during early life and long-term consequences.Key deadlines:
* Abstract submission: Tuesday, September 2
* Housing deadline: Monday, October 6
For more information, visit the Endocrine Society website.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
- Risks and Benefits of Green Spaces for Children: A Cross-Sectional Study of Associations with Sedentary Behavior, Obesity, Asthma, and Allergy
- Genistein Disrupts Glucocorticoid Receptor Signaling in Human Uterine Endometrial Ishikawa Cells
- Modification of the Association between PM10 and Lung Function Decline by Cadherin 13 Polymorphisms in the SAPALDIA Cohort: A Genome-Wide Interaction Analysis
- Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress
- Incense Use and Cardiovascular Mortality among Chinese in Singapore: The Singapore Chinese Health Study
- Perfluorochemicals and Human Semen Quality: The LIFE Study
- Molecular Signaling Network Motifs Provide a Mechanistic Basis for Cellular Threshold Responses
- EHPNoonNews: EPA to clean up Houston hazardous waste site http://t.co/2F9hKH0wFT @houstonchron
- EHPNoonNews: Common epigenomic fingerprint found in multiple cancers http://t.co/2o9Q3QcMWC @genbio
- EHPNoonNews: Cookstoves, highways linked to high blood pressure in China http://t.co/Vv0hb9CyBB @timesofindia
- EHPNoonNews: WHO recommendations on e-cigarettes http://t.co/V9l4U59Nem @bbcworld Related coming in Sept EHP News
- AdvPubl: Risks and benefits of green spaces for children http://t.co/T9E8166bza