Children's Health Advance Publication
Preconception Maternal and Paternal Exposure to Persistent Organic Pollutants and Birth Size: The LIFE Study
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Citation: Robledo CA, Yeung E, Mendola P, Sundaram R, Maisog J, Sweeney AM, Barr DB, Buck Louis GM. Preconception Maternal and Paternal Exposure to Persistent Organic Pollutants and Birth Size: The LIFE Study. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1308016.
Received: 16 December 2013
Accepted: 4 August 2014
Advance Publication: 5 August 2014
Background: Persistent organic pollutants (POPs) are developmental toxicants but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored.
Objective: To examine associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures.
Methods: Parental serum concentrations of 9 organochlorine pesticides, 1 polybrominated biphenyl (PBB), 7 perfluoroalkyl chemicals (PFCs), 10 polybrominated diphenyl ethers (PBDEs) and 36 polychlorinated biphenyls (PCBs) were measured prior to conception for 234 couples. Differences in birth weight, length, head circumference, and ponderal index were estimated using multiple linear regression per 1-standard deviation (SD) increase in natural log-transformed (ln-transformed) chemicals. Models were estimated separately for each parent and adjusted for maternal age, maternal pre-pregnancy BMI (kg/m2) and other confounders, and all models included an interaction term between infant gender and each chemical.
Results: Among girls (n = 117) birth weight was significantly lower (range: 84-195 grams) in association with 1-SD increase in ln-transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183 and paternal serum concentrations of PBDE-183 and PCB-167. Among boys (n = 113), maternal (PCBs: 138, 153, 167, 170, 195, and 209, PFOSA) and paternal (PCBs: 172 and 195) serum concentrations of several POPs were statistically associated with lower birth weight (range: 98-170 grams), while paternal concentrations of PBDEs (66, 99) were associated with higher birth weight. Differences in offspring head circumference, length, and ponderal index were also associated with parental exposures.
Conclusions: Preconceptional maternal and paternal concentrations of several POPs were associated with statistically significant differences in birth size among offspring.
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CEHN September 2014 Article of the Month“Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study” (Environ Health Perspect; DOI:10.1289/ehp.1307562) has been selected by the Children’s Environmental Health Network (CEHN) as its September 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
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