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Children's Health Advance Publication

Environ Health Perspect; DOI:10.1289/ehp.1308016

Preconception Maternal and Paternal Exposure to Persistent Organic Pollutants and Birth Size: The LIFE Study

Candace A. Robledo,1 Edwina Yeung,1 Pauline Mendola,1 Rajeshwari Sundaram,1 Jose Maisog,1 Anne M. Sweeney,2 Dana Boyd Barr,3 and Germaine M. Buck Louis
Author Affiliations close
1Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Rockville, Maryland, USA; 2Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Sciences Center, College Station, Texas, USA; 3Emory University, Rollins School of Public Health, Atlanta, Georgia, USA
About This Article open

This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.

Citation: Robledo CA, Yeung E, Mendola P, Sundaram R, Maisog J, Sweeney AM, Barr DB, Buck Louis GM. Preconception Maternal and Paternal Exposure to Persistent Organic Pollutants and Birth Size: The LIFE Study. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1308016.

Received: 16 December 2013
Accepted: 4 August 2014
Advance Publication: 5 August 2014

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Abstract

Background: Persistent organic pollutants (POPs) are developmental toxicants but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored.

Objective: To examine associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures.

Methods: Parental serum concentrations of 9 organochlorine pesticides, 1 polybrominated biphenyl (PBB), 7 perfluoroalkyl chemicals (PFCs), 10 polybrominated diphenyl ethers (PBDEs) and 36 polychlorinated biphenyls (PCBs) were measured prior to conception for 234 couples. Differences in birth weight, length, head circumference, and ponderal index were estimated using multiple linear regression per 1-standard deviation (SD) increase in natural log-transformed (ln-transformed) chemicals. Models were estimated separately for each parent and adjusted for maternal age, maternal pre-pregnancy BMI (kg/m2) and other confounders, and all models included an interaction term between infant gender and each chemical.

Results: Among girls (n = 117) birth weight was significantly lower (range: 84-195 grams) in association with 1-SD increase in ln-transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183 and paternal serum concentrations of PBDE-183 and PCB-167. Among boys (n = 113), maternal (PCBs: 138, 153, 167, 170, 195, and 209, PFOSA) and paternal (PCBs: 172 and 195) serum concentrations of several POPs were statistically associated with lower birth weight (range: 98-170 grams), while paternal concentrations of PBDEs (66, 99) were associated with higher birth weight. Differences in offspring head circumference, length, and ponderal index were also associated with parental exposures.

Conclusions: Preconceptional maternal and paternal concentrations of several POPs were associated with statistically significant differences in birth size among offspring.


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