Children's Health Advance Publication
Preconception Maternal and Paternal Exposure to Persistent Organic Pollutants and Birth Size: The LIFE Study
This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Robledo CA, Yeung E, Mendola P, Sundaram R, Maisog J, Sweeney AM, Barr DB, Buck Louis GM. Preconception Maternal and Paternal Exposure to Persistent Organic Pollutants and Birth Size: The LIFE Study. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1308016.
Received: 16 December 2013
Accepted: 4 August 2014
Advance Publication: 5 August 2014
Background: Persistent organic pollutants (POPs) are developmental toxicants but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored.
Objective: To examine associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures.
Methods: Parental serum concentrations of 9 organochlorine pesticides, 1 polybrominated biphenyl (PBB), 7 perfluoroalkyl chemicals (PFCs), 10 polybrominated diphenyl ethers (PBDEs) and 36 polychlorinated biphenyls (PCBs) were measured prior to conception for 234 couples. Differences in birth weight, length, head circumference, and ponderal index were estimated using multiple linear regression per 1-standard deviation (SD) increase in natural log-transformed (ln-transformed) chemicals. Models were estimated separately for each parent and adjusted for maternal age, maternal pre-pregnancy BMI (kg/m2) and other confounders, and all models included an interaction term between infant gender and each chemical.
Results: Among girls (n = 117) birth weight was significantly lower (range: 84-195 grams) in association with 1-SD increase in ln-transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183 and paternal serum concentrations of PBDE-183 and PCB-167. Among boys (n = 113), maternal (PCBs: 138, 153, 167, 170, 195, and 209, PFOSA) and paternal (PCBs: 172 and 195) serum concentrations of several POPs were statistically associated with lower birth weight (range: 98-170 grams), while paternal concentrations of PBDEs (66, 99) were associated with higher birth weight. Differences in offspring head circumference, length, and ponderal index were also associated with parental exposures.
Conclusions: Preconceptional maternal and paternal concentrations of several POPs were associated with statistically significant differences in birth size among offspring.
ISEE 2014 Abstracts Now AvailableEHP is pleased to present the abstracts for the 26th annual conference of the International Society for Environmental Epidemiology (ISEE), From Local to Global: Advancing Science for Policy in Environmental Health, held 24–28 August 2014 in Seattle, Washington.
Notice of Intent to RecruitThe National Institute of Environmental Health Sciences will soon announce a search for candidates for the position of Supervisory Technical Editor (Operations Manager) for EHP. The Operations Manager will report directly to the Editor-in-Chief of EHP. To learn more, read the full notice of intent to recruit.
CEHN October 2014 Article of the Month“Maternal Exposure to Criteria Air Pollutants and Congenital Heart Defects in Offspring: Results from the National Birth Defects Prevention Study” (Environ Health Perspect; DOI:10.1289/ehp.1307289) has been selected by the Children’s Environmental Health Network (CEHN) as its October 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
Urinary Metals and Heart Rate Variability: A Cross-Sectional Study of Urban Adults in Wuhan, China
Prenatal Phthalate Exposures and Anogenital Distance in Swedish Boys
Association between Lifetime Exposure to Inorganic Arsenic in Drinking Water and Coronary Heart Disease in Colorado Residents
Building a Robust 21st Century Chemical Testing Program at the U.S. Environmental Protection Agency: Recommendations for Strengthening Scientific Engagement
Cadmium and Proliferation in Human Uterine Leiomyoma Cells: Evidence of a Role for EGFR/MAPK Pathways but Not Classical Estrogen Receptor Pathways