Children's Health Advance Publication
Early-Life Bisphenol A Exposure and Child Body Mass Index: A Prospective Cohort Study
This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Braun JM, Lanphear BP, Calafat AM, Deria S, Khoury J, Howe CJ, Venners SA. Early-Life Bisphenol A Exposure and Child Body Mass Index: A Prospective Cohort Study. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1408258.
Received: 10 February 2014
Accepted: 25 July 2014
Advance Publication: 29 July 2014
Background: Early life bisphenol A (BPA) exposure may increase childhood obesity risk, but few prospective epidemiological studies have investigated this relationship.
Objective: To determine if early life BPA exposure was associated with increased body mass index (BMI) at 2-5 years of age in 297 mother-child pairs from Cincinnati, OH (HOME Study).
Methods: Urinary BPA concentrations were measured in samples collected from pregnant women during the 2nd and 3rd trimesters and their children at 1 and 2 years of age. BMI z-scores were calculated from weight/height measures conducted annually from 2-5 years of age. We used linear mixed models to estimate BMI differences or trajectories with increasing creatinine-normalized BPA concentrations.
Results: After confounder adjustment, each 10-fold increase in prenatal (β = -0.1, 95% confidence limit [CL]: -0.5, 0.3) or early childhood (β = -0.2, CL: -0.6, 0.1) BPA concentrations was associated with a modest and non-significant reduction in child BMI. These inverse associations were suggestively stronger in girls compared to boys (prenatal effect measure modification [EMM] p-value = 0.30, early childhood EMM p-value = 0.05), but sex-specific associations were imprecise. Children in the highest early childhood BPA tercile had lower BMI at 2 years (difference = -0.3; CL: -0.6, 0) and larger increases in their BMI slope from 2-5 years (BMI increase per year = 0.12; CL: 0.07, 0.18) than children in the lowest tercile (BMI increase per year = 0.07; CL: 0.01, 0.13). All associations were attenuated without creatinine-normalization.
Conclusions: Prenatal and early childhood BPA exposures were not associated with increased BMI at 2-5 years, but higher early childhood BPA exposures were associated with accelerated growth during this period.
New Search FunctionWe're pleased to present our improved search page. Try it, and let us know what you think!
CEHN September 2014 Article of the Month“Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study” (Environ Health Perspect; DOI:10.1289/ehp.1307562) has been selected by the Children’s Environmental Health Network (CEHN) as its September 2014 Article of the Month. These CEHN summaries discuss the potential policy implications of current children’s environmental health research.
Register Today for PPTOX IVEnvironmental Stressors in Disease and Implications for Human Health
October 26–29, 2014
Boston Marriott Long Wharf Hotel
Join the Endocrine Society for the fourth international summit of Prenatal Programming and Toxicity (PPTOX), a premiere conference series dedicated to cutting-edge discussion of environmental hazards during early life and long-term consequences.* Housing deadline: Monday, October 6
For more information, visit the Endocrine Society website.
Sign Up to Receive E-mail Alerts
Recent Advance Publications
- Asthma in Inner-City Children at 5-11 Years of Age and Prenatal Exposure to Phthalates: The Columbia Center for Children’s Environmental Health Cohort
- Comparative Assessment of the Effects of Climate Change on Heat- and Cold-Related Mortality in the United Kingdom and Australia
- Proximity to Natural Gas Wells and Reported Health Status: Results of a Household Survey in Washington County, Pennsylvania
- Green and Blue Spaces and Behavioral Development in Barcelona Schoolchildren: The BREATHE Project
- Aerial Application of Mancozeb and Urinary Ethylene Thiourea (ETU) Concentrations among Pregnant Women in Costa Rica: The Infants’ Environmental Health Study (ISA)
- Pyrethroid Pesticide Exposure and Parental Report of Learning Disability and Attention Deficit/Hyperactivity Disorder in U.S. Children: NHANES 1999–2002
- Household Cooking with Solid Fuels Contributes to Ambient PM2.5 Air Pollution and the Burden of Disease
- EHPNoonNews: Filtration system for arsenic-contaminated water http://t.co/ipwZ7jVFNr @abc7newsbayarea
- EHPNoonNews: House dust, ammunition lead to high lead levels in Inuit http://t.co/gQ4sAshGmf @nunatsiaqnews
- EHPNoonNews: Shark skin: an inspiration for hygiene? http://t.co/PvYigVMgUr @eurekalertaaas
- EHPNoonNews: Florida red tide could hit economy http://t.co/ptF2MmYmWQ @washingtonpost Related in EHP http://t.co/OF88aDTKH6
- AdvPubl: Prenatal phthalates and child asthma http://t.co/SDGhtmwyO5