Children's Health Advance Publication
Early-Life Bisphenol A Exposure and Child Body Mass Index: A Prospective Cohort Study
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Citation: Braun JM, Lanphear BP, Calafat AM, Deria S, Khoury J, Howe CJ, Venners SA. Early-Life Bisphenol A Exposure and Child Body Mass Index: A Prospective Cohort Study. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1408258.
Received: 10 February 2014
Accepted: 25 July 2014
Advance Publication: 29 July 2014
Background: Early life bisphenol A (BPA) exposure may increase childhood obesity risk, but few prospective epidemiological studies have investigated this relationship.
Objective: To determine if early life BPA exposure was associated with increased body mass index (BMI) at 2-5 years of age in 297 mother-child pairs from Cincinnati, OH (HOME Study).
Methods: Urinary BPA concentrations were measured in samples collected from pregnant women during the 2nd and 3rd trimesters and their children at 1 and 2 years of age. BMI z-scores were calculated from weight/height measures conducted annually from 2-5 years of age. We used linear mixed models to estimate BMI differences or trajectories with increasing creatinine-normalized BPA concentrations.
Results: After confounder adjustment, each 10-fold increase in prenatal (β = -0.1, 95% confidence limit [CL]: -0.5, 0.3) or early childhood (β = -0.2, CL: -0.6, 0.1) BPA concentrations was associated with a modest and non-significant reduction in child BMI. These inverse associations were suggestively stronger in girls compared to boys (prenatal effect measure modification [EMM] p-value = 0.30, early childhood EMM p-value = 0.05), but sex-specific associations were imprecise. Children in the highest early childhood BPA tercile had lower BMI at 2 years (difference = -0.3; CL: -0.6, 0) and larger increases in their BMI slope from 2-5 years (BMI increase per year = 0.12; CL: 0.07, 0.18) than children in the lowest tercile (BMI increase per year = 0.07; CL: 0.01, 0.13). All associations were attenuated without creatinine-normalization.
Conclusions: Prenatal and early childhood BPA exposures were not associated with increased BMI at 2-5 years, but higher early childhood BPA exposures were associated with accelerated growth during this period.
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