Children's Health Advance Publication
Environ Health Perspect; DOI:10.1289/ehp.1510065
Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire
*Indicates equal contribution to this paper
PDF Version (365 KB)
Background: Studies suggest that arsenic exposure influences birth outcomes, however findings are mixed.
Objective: We assessed in utero arsenic exposure in relation to birth outcomes and whether maternal pre-pregnancy weight and infant sex modified associations.
Methods: Among 706 mother-infant pairs exposed to low levels of arsenic through drinking water and diet, we assessed in utero arsenic exposure using maternal second trimester urinary arsenic, maternal pre-pregnancy weight through self-report, and birth outcomes from medical records.
Results: Median (IQ range) of total urinary arsenic (tAs; inorganic arsenic (iAs) + monomethylarsonic acid (MMA) + dimethylarsinic acid (DMA)) was 3.4 µg/L (1.7 – 6.0). In adjusted linear models, each doubling of tAs was associated with a 0.10 cm decrease (95% CI: -0.19, -0.01) in head circumference. Results were similar for MMA and DMA. Ln(tAs) and Ln (DMA) were positively associated with birth length in infant males only; among males, each doubling of tAs was associated with a 0.28 cm increase (95% CI: 0.09, 0.46) birth length (Pinteraction = 0.04). Results were similar for DMA. Additionally, arsenic exposure was inversely related to Ponderal Index and associations differed by maternal weight. Each Ln(tAs) doubling of tAs was associated with a 0.55 kg/m3 lower (95% CI: -0.82, -0.28, P<0.001) Ponderal Index for infants of overweight/obese, but not normal weight, mothers, (Pinteraction <0.01). Finally, there was a significant interaction between maternal weight status, infant sex, and arsenic exposure on birth weight (Pinteraction = 0.03). In girls born of overweight/obese mothers, each doubling of tAs was associated with a 62.9 g decrease (95% CI: -111.6, -14.2) in birth weight, though the association was null in the other strata.
Conclusions: Low-level arsenic exposure may impact fetal growth, and the associations may be modified by maternal weight status and infant sex.
This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.
Citation: Gilbert-Diamond D, Emond JA, Baker ER, Korrick SA, Karagas MR. Relation between in Utero Arsenic Exposure and Birth Outcomes in a Cohort of Mothers and Their Newborns from New Hampshire. Environ Health Perspect; http://dx.doi.org/10.1289/ehp.1510065
Received: 10 April 2015
Accepted: 12 February 2016
Advance Publication: 8 March 2016
Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact firstname.lastname@example.org. Our staff will work with you to assess and meet your accessibility needs within 3 working days.
Supplemental Material PDF (246 KB)
Note to readers with disabilities: EHP has provided a 508-conformant table of contents summarizing the Supplemental Material for this article (see below) so readers with disabilities may determine whether they wish to access the full, nonconformant Supplemental Material. If you need assistance accessing this or any other content on this site, please contact email@example.com. Our staff will work with you to assess and meet your accessibility needs within 3 working days.
Supplemental Table of Contents PDF (102 KB)
Attention, Authors: New Submission System
EHP is now using Editorial Manager for manuscript submissions. All user accounts have been transferred to Editorial Manager—just log into Editorial Manager and reset your password. Editorial Manager offers an in-depth help index; for further questions, contact firstname.lastname@example.org. We hope you enjoy using our streamlined new submission system!
Sign Up to Receive E-mail Alerts
Recent Advance Publications
Urban Dust Microbiome: Impact on Later Atopy and Wheezing
Use of Cooking Fuels and Cataract in a Population-Based Study: The India Eye Disease Study
Particulate Air Pollution and Fasting Blood Glucose in Non-Diabetic Individuals: Associations and Epigenetic Mediation in the Normative Aging Study, 2000-2011
Persistent Organic Pollutants and the Association with Maternal and Infant Thyroid Homeostasis: A Multipollutant Assessment
A Systematic Comparison of Linear Regression-Based Statistical Methods to Assess Exposome-Health Associations