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Environ Health Perspect; DOI:10.1289/ehp.1510391

Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community

Lyndsey A. Darrow1,2,3, Alyx C. Groth2, Andrea Winquist2,3, Hyeong-Moo Shin4,5, Scott M. Bartell6, and Kyle Steenland2,3
Author Affiliations open
1School of Community Health Sciences, University of Nevada, Reno, Reno, Nevada, USA; 2Department of Epidemiology, Emory University, Atlanta, Georgia, USA; 3Department of Environmental Health, Emory University, Atlanta, Georgia, USA; 4Department of Public Health Sciences, University of California, Davis, Davis, California, USA; 5School of Social Ecology, University of California, Irvine, Irvine, California, USA; 6Department of Statistics and Department of Epidemiology, University of California, Irvine, Irvine, California, USA

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  • Background: Perfluorooctanoic acid (PFOA or C8) has hepatotoxic effects in animals. Cross-sectional epidemiologic studies suggest PFOA is associated with liver injury biomarkers.

    Objectives: We estimated associations between modeled historical PFOA exposures and liver injury biomarkers and medically-validated liver disease.

    Methods: Participants completed surveys during 2008-2011 reporting demographic, medical, and residential history information. Self-reported liver disease, including hepatitis, fatty liver, enlarged liver and cirrhosis, was validated with healthcare providers. Alanine aminotransferase (ALT), γ-glutamyltransferase (GGT) and direct bilirubin, markers of liver toxicity, were obtained from blood samples collected in the C8 Health Project (2005-2006). Historically modeled PFOA exposure, estimated using environmental fate and transport models and participant residential histories, was analyzed in relation to liver biomarkers (n=30,723, including 1892 workers) and liver disease (n=32,254, including 3713 workers).

    Results: Modeled cumulative serum PFOA was positively associated with ALT levels (p for trend <0.0001), indicating possible liver toxicity. An increase from the first to the fifth quintile of cumulative PFOA exposure was associated with a 6% increase in ALT levels (95%CI: 4-8%) and a 16% increased odds of having above-normal ALT (95%CI odds ratio: 1.02-1.33%). There was no indication of association with either elevated direct bilirubin or GGT; however, PFOA was associated with decreased direct bilirubin. We observed no evidence of an effect of cumulative exposure (with or without a 10-year lag) on all liver disease (n=647 cases), nor on enlarged liver, fatty liver and cirrhosis only (n=427 cases).

    Conclusion: Results are consistent with previous cross-sectional studies showing association between PFOA and ALT, a marker of hepatocellular damage. We did not observe evidence that PFOA increases the risk of clinically-diagnosed liver disease.

  • This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.

    Citation: Darrow LA, Groth AC, Winquist A, Shin HM, Bartell SM, Steenland K. Modeled Perfluorooctanoic Acid (PFOA) Exposure and Liver Function in a Mid-Ohio Valley Community. Environ Health Perspect;

    Received: 26 June 2015
    Accepted: 22 February 2016
    Advance Publication: 15 March 2016

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