December 2012 | Volume 120 | Issue 12

News

Focus

Healthier Tribal Housing: Combining the Best of Old and New

Nate Seltenrich | A460-A469

Comprehensive statistics are hard to come by, but anecdotal evidence suggests mold infestation is an extensive problem in Native American tribal housing. At the Oglala Sioux Pine Ridge Indian Reservation in South Dakota, the Oglala Lakota Housing Authority has reportedly estimated that 75% of homes may be contaminated with mold. A 2010 Montana State University study of 406 homes on reservations throughout the state identified visible mold growing in the bathrooms of more than a third. And the Associated Press reported in 2001 that at least 320 homes in a single housing development on North Dakota’s Turtle Mountain Indian Reservation were contaminated with mold, two-thirds of them so severely that they had to be destroyed.

Forum

Global Trade Tradeoff: Rickettsial Disease in Taiwan

Sharon Levy | A456

Still Searching for Better Butter Flavoring

Carol Potera | A457

Organic Food Conclusions Don’t Tell the Whole Story

David C. Holzman | A458

The Beat

Erin Dooley | A459

On the Cover | Spheres of Influence

Progress and Pollution: Port Cities Prepare for the Panama Canal Expansion

Andrea Hricko | A470-A473

Early in the planning of the Panama Canal, Navy Commander Thomas Oliver Selfridge, Jr., wrote that “advantageous as an interoceanic canal would be to the commercial welfare of the whole world, it is doubly so for the necessities of American interests.” And indeed, since the Canal opened in 1914, it has been the main conduit for ocean-going ships carrying trade worldwide. Today the United States ranks number one in tons of cargo passing through the Canal (China ranks number two). In 2011 nearly 13,000 ocean-going cargo ships made the passage.

Science Selections

Potential Obesogen Identified: Fungicide Triflumizole Is Associated with Increased Adipogenesis in Mice

Valerie J. Brown | A474

Exposure Intimacy: A New Metric for Assessing Chemical Intake

Kellyn S. Betts | A474

Don’t Hold Your Breath: Indoor CO₂ Exposure and Impaired Decision Making

Tanya Tillett | A475

Crispy Cravings May Affect Baby’s Health: Prenatal Acrylamide Exposure Is Associated with Reduced Birth Weight

Julia R. Barrett | A475

Reviews

Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry

Richard M. LoPachin and Terrence Gavin | 1650-1657

Evaluation of the Association between Arsenic and Diabetes: A National Toxicology Program Workshop Review

Elizabeth A. Maull, Habibul Ahsan, Joshua Edwards, Matthew P. Longnecker, Ana Navas-Acien, Jingbo Pi, Ellen K. Silbergeld, Miroslav Styblo, Chin-Hsiao Tseng, Kristina A. Thayer, and Dana Loomis | 1658-1670

Commentaries

The Role of Ambient Ozone in Epidemiologic Studies of Heat-Related Mortality

Colleen E. Reid, Jonathan M. Snowden, Caitlin Kontgis, and Ira B. Tager | 1628-1630

Animal Use and Lessons Learned in the U.S. High Production Volume Chemicals Challenge Program

Patricia L. Bishop, Joseph R. Manuppello, Catherine E. Willett, and Jessica T. Sandler | 1631-1639

Consortium-Based Science: The NIEHS’s Multipronged, Collaborative Approach to Assessing the Health Effects of Bisphenol A

Linda S. Birnbaum, John R. Bucher, Gwen W. Collman, Darryl C. Zeldin, Anne F. Johnson, Thaddeus T. Schug, and Jerrold J. Heindel | 1640-1644

Indigenous Peoples of North America: Environmental Exposures and Reproductive Justice

Elizabeth Hoover, Katsi Cook, Ron Plain, Kathy Sanchez, Vi Waghiyi, Pamela Miller, Renee Dufault, Caitlin Sislin, and David O. Carpenter | 1645-1649

Research

Is CO₂ an Indoor Pollutant? Direct Effects of Low-to-Moderate CO₂ Concentrations on Human Decision-Making Performance

Usha Satish, Mark J. Mendell, Krishnamurthy Shekhar, Toshifumi Hotchi, Douglas Sullivan, Siegfried Streufert, and William J. Fisk | 1671-1677

Intake to Production Ratio: A Measure of Exposure Intimacy for Manufactured Chemicals

William Nazaroff, Charles J. Weschler, John C. Little, and Elaine A. Cohen Hubal | 1678-1683

Exposure of Rats to Environmental Tobacco Smoke during Cerebellar Development Alters Behavior and Perturbs Mitochondrial Energetics

Brian F. Fuller, Diego F. Cortes, Miranda K. Landis, Hiyab Yohannes, Hailey E. Griffin, Jillian E. Stafflinger, M. Scott Bowers, Mark H. Lewis, Michael A. Fox, and Andrew K. Ottens | 1684-1691

Hyaluronan Activation of the Nlrp3 Inflammasome Contributes to the Development of Airway Hyperresponsiveness

Feifei Feng, Zhuowei Li, Erin N. Potts-Kant, Yiming Wu, W. Michael Foster, Kristi L. Williams, and John W. Hollingsworth | 1692-1698

Environmental Inequality in Exposures to Airborne Particulate Matter Components in the United States

Michelle L. Bell and Keita Ebisu | 1699-1704

Dose Reconstruction of Di(2-ethylhexyl) Phthalate Using a Simple Pharmacokinetic Model

Matthew Lorber and Antonia M. Calafat | 1705-1710

Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a Novel Brominated Flame Retardant Present in Indoor Dust

Cecilia Springer, Edward Dere, Susan J. Hall, Elizabeth V. McDonnell, Simon C. Roberts, Craig M. Butt, Heather M. Stapleton, Deborah J. Watkins, Michael D. McClean, Thomas F. Webster, Jennifer J. Schlezinger, and Kim Boekelheide | 1711-1719

Triflumizole Is an Obesogen in Mice that Acts through Peroxisome Proliferator Activated Receptor Gamma (PPARγ)

Xia Li, Hang T. Pham, Amanda S. Janesick, and Bruce Blumberg | 1720-1726

Comparison of Geostatistical Interpolation and Remote Sensing Techniques for Estimating Long-Term Exposure to Ambient PM_2.5 Concentrations across the Continental United States

Seung-Jae Lee, Marc L. Serre, Aaron van Donkelaar, Randall V. Martin, Richard T. Burnett, and Michael Jerrett | 1727-1732

Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh

Wei Jie Seow, Wen-Chi Pan, Molly L. Kile, Andrea A. Baccarelli, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin, Golam Mostofa, Xihong Lin, and David C. Christiani | 1733-1738

Children’s Health

Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Marie Pedersen, Hans von Stedingk, Maria Botsivali, Silvia Agramunt, Jan Alexander, Gunnar Brunborg, Leda Chatzi, Sarah Fleming, Eleni Fthenou, Berit Granum, Kristine B. Gutzkow, Laura J. Hardie, Lisbeth E. Knudsen, Soterios A. Kyrtopoulos, Michelle A. Mendez, Domenico F. Merlo, Jeanette K. Nielsen, Per Rydberg, Dan Segerbäck, Jordi Sunyer, John Wright, Margareta Törnqvist, Jos C. Kleinjans, Manolis Kogevinas, and the NewGeneris Consortium | 1739-1745

Airborne PM_2.5 Chemical Components and Low Birth Weight in the Northeastern and Mid-Atlantic Regions of the United States

Keita Ebisu and Michelle L. Bell | 1746-1752

Air Pollution Exposure and Markers of Placental Growth and Function: The Generation R Study

Edith H. van den Hooven, Frank H. Pierik, Yvonne de Kluizenaar, Albert Hofman, Sjoerd W. van Ratingen, Peter Y.J. Zandveld, Henk Russcher, Jan Lindemans, Henk M.E. Miedema, Eric A.P. Steegers, and Vincent W.V. Jaddoe | 1753-1759

Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk and Neuropsychological Development in Infants

Mireia Gascon, Marta Fort, David Martínez, Anne-Elie Carsin, Joan Forns, Joan O. Grimalt, Loreto Santa Marina, Nerea Lertxundi, Jordi Sunyer, and Martine Vrijheid | 1760-1765

Perspectives

Editorials

Advancing Knowledge on the Environment and Its Impact on Health, and Meeting the Challenges of Global Environmental Change

Fan Wu | A450

EHP Paper of the Year, 2012

Hugh A. Tilson | A451