Introduction--Pharmacokinetics: Defining Dosimetry for Risk Assessment
p. 3

Basic Issues in Pharmacokinetics

A Tiered Approach to Pharmacokinetic Studies

Alan G. E. Wilson, Stephen W. Frantz, and Leonard C. Keifer
p. 5

Pharmacokinetic Factors Influencing Risk Assessment: Saturation of Biochemical Processes and Cofactor Depletion

Darrell D. Sumner and James T. Stevens
p. 13

A Carbamate Insecticide: A Case Study of Aldicarb

Ronald L. Baron
p. 23

Factors Affecting Mammary Tumor Incidence in Chloratriazine-treated Female Rats: Hormonal Properties, Dosage, and Animal Strain

J. Charles Eldridge, Marie K. Tennant, Lawrence T. Wetzel, Charles B. Breckenridge, and James T. Stevens
p. 29

Use of Pharmacokinetic Models

Applications of Physiologic Pharmacokinetic Modeling in Carcinogenic Risk Assessment

Daniel Krewski, James R. Withey, Lung-fa Ku, and Melvin E. Anderson
p. 37

Physiologically Based Pharmacokinetic Model for the Inhibition of Acetylcholinesterase by Organophosphate Esters

Jeffery M. Gearhart, Gary W. Jepson, Harvey J. Clewell, Melvin E. Anderson, and Rory B. Conolly
p. 51

Parameter Variability and the Interpretation of Physiologically Based Pharmacokinetic Modeling Results

Robert C. Spear and Frederic Y. Bois
p. 61

Contribution of Extraheptaic Metabolism to Formation of Toxic Metabolites

Uptake and Metabolism of Toxicants in the Respiratory Tract

Alan R. Dahl and Per Gerde
p. 67

Influence of Metabolism in Skin on Dosimetry after Topical Exposure

Robert L. Bronaugh, Steven W. Collier, Sara E. Macpherson, and Margaret E. K. Kraeling
p. 71

Role of Renal Metabolism in Risk to Toxic Chemicals

Lawrence H. Lash
p. 75

Pharmacokinetics in Sensitive Populations

Pharmacogenetics: Detecting Sensitive Populations

Peter G. Shields
p. 81

Chemical Contaminants, Pharmacokinetics, and the Lactating Mother

Walter J. Rogan and N. Beth Ragan
p. 89

Pharmacokinetic Determinants of Embryotoxicity in Rats Associated with Organic Acids

William J. Scott, Jr., Michael D. Collins, and Heinz Nau
p. 97

Physiologic Changes during Growth and Development

Ellen J. O'Flaherty
p. 103

Pharmacokinetics in the Infant

Rebecca L. Milsap and William J. Jusko
p. 107

Pharmacokinetics in the Child

William R. Crom
p. 111

Pharmacokinetics in the Elderly

Michael Mayersohn
p. 119

Summary of Panel Discussions

Rogene F. Henderson and Kulbir S. Bakshi
p. 125

Last update: September 15, 1998