| Monte Carlo Results for the 3-Poly Test for Animal Carcinogenicity Experiments
Wai-Yuan Tan and Jane Honyuang Zhang Department of Mathematical Sciences, University of Memphis, Memphis, TN 38152 USA Abstract
By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test for animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators with moderate or large effect, but, in some cases, it is less powerful for weak initiators or weak promoters. As expected, the 3-poly test is insensitive to the toxicity of many agents. Key words: carcinogenicity experiment, initiator, Monte Carlo, 3-poly test, promoter, toxicity, two-stage model. Environ Health Perspect 104:872-877 (1996) Address correspondence to W. Y. Tan, 8031 Brooxie Cove, Germantown, TN 38138 USA. Received 14 November 1995 ; accepted 10 April 1996.
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