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Ricki M. Helm,¹ Richard W. Ermel,² and Oscar L. Frick³

¹Department of Pediatrics, Division of Allergy/Immunology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital Research Institute, Little Rock, Arkansas, USA; ²Animal Resources Center, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA; ³University of California San Francisco, School of Medicine, Department of Pediatrics, Division of Allergy/Immunology, San Francisco, California, USA

Abstract

Food allergy can present as immediate hypersensitivity [manifestations mediated by immunoglobulin (Ig) E], delayed-type hypersensitivity (reactions associated with specific T lymphocytes) , and inflammatory reactions caused by immune complexes. For reasons of ethics and efficacy, investigations in humans to determine sensitization and allergic responses of IgE production to innocuous food proteins are not feasible. Therefore, animal models are used a) to bypass the innate tendency to develop tolerance to food proteins and induce specific IgE antibody of sufficient avidity/affinity to cause sensitization and upon reexposure to induce an allergic response, b) to predict allergenicity of novel proteins using characteristics of known food allergens, and c) to treat food allergy by using immunotherapeutic strategies to alleviate life-threatening reactions. The predominant hypothesis for IgE-mediated food allergy is that there is an adverse reaction to exogenous food proteins or food protein fragments, which escape lumen hydrolysis, and in a polarized helper T cell subset 2 (Th2) environment, immunoglobulin class switching to allergen-specific IgE is generated in the immune system of the gastrointestinal-associated lymphoid tissues. Traditionally, the immunologic characterization and toxicologic studies of small laboratory animals have provided the basis for development of animal models of food allergy ; however, the natural allergic response in large animals, which closely mimic allergic diseases in humans, can also be useful as models for investigations involving food allergy. Key words: allergens, atopic dog, gastrointestinal food allergy, swine. Environ Health Perspect 111:239-244 (2003) . doi:10.1289/ehp.5705 available via http://dx.doi.org/ [Online 21 January 2003]