IMMUNOLOGY | Perinatal Immunotoxicity: Why Adult Exposure Assessment Fails to Predict Risk
Rodney R. Dietert and Michael S. Piepenbrink
p. 477 [ Abstract ] [ Full ] [ PDF ]

TOXICOLOGY | Monensin Improves the Effectiveness of meso-Dimercaptosuccinate when Used to Treat Lead Intoxication in Rats
Shawn A. Hamidinia, Warren L. Erdahl, Clifford J. Chapman, Gregory E. Steinbaugh, Richard W. Taylor, and Douglas R. Pfeiffer
p. 484 [ Abstract ] [ Full ] [ PDF ]

BIOMARKERS | Occupational Toluene Exposure Induces Cytochrome P450 2E1 mRNA Expression in Peripheral Lymphocytes
Ania Mendoza-Cantú, Fabiola Castorena-Torres, Mario Bermúdez de León, Bulmaro Cisneros, Lizbeth López-Carrillo, Aurora E. Rojas-García, Alberto Aguilar-Salinas, Maurizio Manno, and Arnulfo Albores
p. 494 [ Abstract ] [ Full ] [ PDF ]

ENVIRONMENTAL TOXICOLOGY | Antiestrogens Inhibit Xenoestrogen-Induced Brain Aromatase Activity but Do Not Prevent Xenoestrogen-Induced Feminization in Japanese Medaka (Oryzias latipes)
Adam J. Kuhl and Marius Brouwer
p. 500 [ Abstract ] [ Full ] [ PDF ]

SIGNAL TRANSDUCTION | Lead Increases Lipopolysaccharide-Induced Liver Injury through Tumor Necrosis Factor- Overexpression by Monocytes/Macrophages: Role of Protein Kinase C and p42/44 Mitogen-Activated Protein Kinase
Yu-Jung Cheng, Bei-Chang Yang, and Ming-Yie Liu
p. 507 [ Abstract ] [ Full ] [ PDF ]

EXPOSURE ASSESSMENT | Changes in Breath Trihalomethane Levels Resulting from Household Water-Use Activities
Sydney M. Gordon, Marielle C. Brinkman, David L. Ashley, Benjamin C. Blount, Christopher Lyu, John Masters, and Philip C. Singer
p. 514 [ Abstract ] [ Full ] [ PDF ]

EXPOSURE ASSESSMENT | National Prevalence and Exposure Risk for Cockroach Allergen in U.S. Households
Richard D. Cohn, Samuel J. Arbes Jr., Renee Jaramillo, Laura H. Reid, and Darryl C. Zeldin
p. 522 [ Abstract ] [ Full ] [ PDF ]

TOXICOLOGY | Methylarsonous Acid Transport by Aquaglyceroporins
Zijuan Liu, Miroslav Styblo, and Barry P. Rosen
p. 527 [ Abstract ] [ Full ] [ PDF ]

EXPOSURE ASSESSMENT | The Exposure-Response Curve for Ozone and Risk of Mortality and the Adequacy of Current Ozone Regulations
Michelle L. Bell, Roger D. Peng, and Francesca Dominici
Also see Science Selections, p. A240
p. 532 [ Abstract ] [ Full ] [ PDF ]

TOXICOLOGY | A Survival-Adjusted Quantal-Response Test for Analysis of Tumor Incidence Rates in Animal Carcinogenicity Studies
Shyamal D. Peddada and Grace E. Kissling
p. 537 [ Abstract ] [ Full ] [ PDF ]

BIOMONITORS | The Effect of Inhaled Chromium on Different Exhaled Breath Condensate Biomarkers among Chrome-Plating Workers
Andrea Caglieri, Matteo Goldoni, Olga Acampa, Roberta Andreoli, Maria Vittoria Vettori, Massimo Corradi, Pietro Apostoli, and Antonio Mutti
p. 542 [ Abstract ] [ Full ] [ PDF ]

ENVIRONMENTAL TOXICOLOGY | Evolutionary Toxicology: Population-Level Effects of Chronic Contaminant Exposure on the Marsh Frogs (Rana ridibunda) of Azerbaijan
Cole W. Matson, Megan M. Lambert, Thomas J. McDonald, Robin L. Autenrieth, Kirby C. Donnelly, Arif Islamzadeh, Dmitri I. Politov, and John W. Bickham
p. 547 [ Abstract ] [ Full ] [ PDF ]

CELL CYCLE CONTROL | Profiles of Global Gene Expression in Ionizing-Radiation- Damaged Human Diploid Fibroblasts Reveal Synchronization behind the G₁ Checkpoint in a G₀-like State of Quiescence
Tong Zhou, Jeff W. Chou, Dennis A. Simpson, Yingchun Zhou, Thomas E. Mullen, Margarida Medeiros, Pierre R. Bushel, Richard S. Paules, Xuebin Yang, Patrick Hurban, Edward K. Lobenhofer, and William K. Kaufmann
p. 553 [ Abstract ] [ Full ] [ PDF ]

CARDIOVASCULAR DISEASE | The Relationship between Ambient Air Pollution and Heart Rate Variability Differs for Individuals with Heart and Pulmonary Disease
Amanda Wheeler, Antonella Zanobetti, Diane R. Gold, Joel Schwartz, Peter Stone, and Helen H. Suh
p. 560 [ Abstract ] [ Full ] [ PDF ]

EPIGENETICS | Maternal Genistein Alters Coat Color and Protects A^vy Mouse Offspring from Obesity by Modifying the Fetal Epigenome
Dana C. Dolinoy, Jennifer R. Weidman, Robert A. Waterland, and Randy L. Jirtle
Also see Science Selections, p. A240
p. 567 [ Abstract ] [ Full ] [ PDF ]

TOXICOGENOMICS | Workgroup Report: Review of Genomics Data Based on Experience with Mock Submissions--View of the CDER Pharmacology Toxicology Nonclinical Pharmacogenomics Subcommittee
John K. Leighton, Paul Brown, Amy Ellis, Patricia Harlow, Wafa Harrouk, P. Scott Pine, Timothy Robison, Lilliam Rosario, and Karol Thompson
p. 573 [ Abstract ] [ Full ] [ PDF ]

CARDIOVASCULAR | The Effect of Chelation on Blood Pressure in Lead-Exposed Children: A Randomized Study
Aimin Chen, George G. Rhoads, Bo Cai, Mikhail Salganik, and Walter J. Rogan
Also see Science Selections, p. A241
p. 579 [ Abstract ] [ Full ] [ PDF ]

HUMAN TOXICOLOGY | Renal and Neurologic Effects of Cadmium, Lead, Mercury, and Arsenic in Children: Evidence of Early Effects and Multiple Interactions at Environmental Exposure Levels
Claire de Burbure, Jean-Pierre Buchet, Ariane Leroyer, Catherine Nisse, Jean-Marie Haguenoer, Antonio Mutti, Zdenek Smerhovsky´, Miroslav Cikrt, Malgorzata Trzcinka-Ochocka, Grazyna Razniewska, Marek
p. 584 [ Abstract ] [ Full ] [ PDF ]

ENVIRONMENTAL JUSTICE | Race, Poverty, and Potential Exposure of Middle-School Students to Air Emissions from Confined Swine Feeding Operations
Maria C. Mirabelli, Steve Wing, Stephen W. Marshall, and Timothy C. Wilcosky
Also see Science Selections, p. A241
p. 591 [ Abstract ] [ Full ] [ PDF ]

FETAL DEVELOPMENT | Association of In Utero Organochlorine Pesticide Exposure and Fetal Growth and Length of Gestation in an Agricultural Population
Laura Fenster, Brenda Eskenazi, Meredith Anderson, Asa Bradman, Kim Harley, Hedy Hernandez, Alan Hubbard, and Dana B. Barr
p. 597 [ Abstract ] [ Full ] [ PDF ]

EXPOSURE ASSESSMENT | Urinary 1-Hydroxypyrene as a Biomarker of PAH Exposure in 3-Year-Old Ukrainian Children
Amy Pelka Mucha, Daniel Hryhorczuk, Andrij Serdyuk, Joseph Nakonechny, Alexander Zvinchuk, Serap Erdal, Motria Caudill, Peter Scheff, Elena Lukyanova, Zoreslava Shkiryak-Nyzhnyk, and Natalia Chislovska
p. 603 [ Abstract ] [ Full ] [ PDF ]

RESPIRATORY DISEASE | Airborne Endotoxin Is Associated with Respiratory Illness in the First 2 Years of Life
Robert Dales, David Miller, Ken Ruest, Mireille Guay, and Stan Judek
p. 610 [ Abstract ] [ Full ] [ PDF ]

ASTHMA | Induction of Asthma and the Environment: What We Know and Need to Know
MaryJane K. Selgrade, Robert F. Lemanske Jr., M. Ian Gilmour, Lucas M. Neas, Marsha D.W. Ward, Paul K. Henneberger, David N. Weissman, Jane A. Hoppin, Rodney R. Dietert, Peter D. Sly, Andrew M. Geller, Paul L. Enright, Gillian S. Backus, Philip A. Bromberg, Dori R. Germolec, and Karin B. Yeatts
p. 615 [ Abstract ] [ Full ] [ PDF ]

ASTHMA | How Exposures to Biologics Influence the Induction and Incidence of Asthma
Darryl C. Zeldin, Peyton Eggleston, Martin Chapman, Giovanni Piedimonte, Harard Renz, and David Peden
p. 620 [ Abstract ] [ Full ] [ PDF ]

ASTHMA | How Exposure to Environmental Tobacco Smoke, Outdoor Air Pollutants, and Increased Pollen Burdens Influences the Incidence of Asthma
M. Ian Gilmour, Maritta S. Jaakkola, Stephanie J. London, Andre E. Nel, and Christine A. Rogers
p. 627 [ Abstract ] [ Full ] [ PDF ]

ASTHMA | A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research
Karin Yeatts, Peter Sly, Stephanie Shore, Scott Weiss, Fernando Martinez, Andrew Geller, Philip Bromberg, Paul Enright, Hillel Koren, David Weissman, and MaryJane Selgrade
p. 634 [ Abstract ] [ Full ] [ PDF ]