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| On the Cover | In the past 30 years, scientists have made great strides in identifying agents in the environment that may have potential for harm. The next step in the journey toward understanding of how disease is caused is to elucidate exactly how and to what humans are exposed, and to link this information to biological changes in people. The Focus (p. A528) describes exposure biology, a new paradigm for environmental health research that is making the leap from the theoretical to the actual.
image credit: Joseph Tart/EHP, Shutterstock Purchase This Issue | |
Perspectives
Correspondence
p. A 516
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Environews
Forum
p. A 520
NIEHS News
p. A 524
Focus
p. A 528
Spheres of Influence
p. A 536
Innovations
p. A 540
Science Selections
p. A 544
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Commentaries & Reviews
HEALTH POLICY | Chemical Plants Remain Vulnerable to Terrorists: A Call to Action
Tobi Mae Lippin, Thomas H. McQuiston, Kristin Bradley-Bull, Toshiba Burns-Johnson, Linda Cook, Michael L. Gill, Donna Howard, Thomas A. Seymour, Doug Stephens, and Brian K. Williams
p. 1307 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | The Chernobyl Accident 20 Years On: An Assessment of the Health Consequences and the International Response
Keith Baverstock and Dillwyn Williams
p. 1312 [ Abstract ] [ Full ] [ PDF ]
CLIMATE CHANGE | Climate Change and Human Health Impacts in the United States: An Update on the Results of the U.S. National Assessment
Kristie L. Ebi, David M. Mills, Joel B. Smith, and Anne Grambsch
p. 1318 [ Abstract ] [ Full ] [ PDF ]
Research
RESPIRATORY DISEASE | Effects of Airway Exposure to Nanoparticles on Lung Inflammation Induced by Bacterial Endotoxin in Mice
Ken-ichiro Inoue, Hirohisa Takano, Rie Yanagisawa, Seishiro Hirano, Miho Sakurai, Akinori Shimada, and Toshikazu Yoshikawa
p. 1325 [ Abstract ] [ Full ] [ PDF ]
CARDIOVASCULAR DISEASE | Extreme Temperatures and Mortality: Assessing Effect Modification by Personal Characteristics and Specific Cause of Death in a Multi-City Case-Only Analysis
Mercedes Medina-Ramón, Antonella Zanobetti, David Paul Cavanagh, and Joel Schwartz
 Also see Science Selections, p. A545
p. 1331 [ Abstract ] [ Full ] [ PDF ]
GENE EXPRESSION | Gene Expression Changes Related to Endocrine Function and Decline in Reproduction in Fathead Minnow (Pimephales promelas) after Dietary Methylmercury Exposure
Rebecca Klaper, Christopher B. Rees, Paul Drevnick, Daniel Weber, Mark Sandheinrich, and Michael J. Carvan
p. 1337 [ Abstract ] [ Full ] [ PDF ]
CLIMATE CHANGE | The Relation between Temperature, Ozone, and Mortality in Nine French Cities during the Heat Wave of 2003
Laurent Filleul, Sylvie Cassadou, Sylvia Médina, Pascal Fabres, Agnés Lefranc, Daniel Eilstein, Alain Le Tertre, Laurence Pascal, Benoit Chardon, Myriam Blanchard, Christophe Declercq, Jean-François Jusot, Hélène Prouvost, and Martine Ledrans
p. 1344 [ Abstract ] [ Full ] [ PDF ]
REPRODUCTIVE HEALTH | Reproductive Hormone Levels in Men Exposed to Persistent Organohalogen Pollutants: A Study of Inuit and Three European Cohorts
Aleksander Giwercman, Anna Rignell-Hydbom, Gunnar Toft, Lars Rylander, Lars Hagmar, Christian Lindh, Henning S. Pedersen, Jan K. Ludwicki, Vladimir Lesovoy, Maryna Shvets, Marcello Spano, Gian Carlo Manicardi, Davide Bizzaro, Eva C. Bonefeld-Jorgensen, Jens Peter Bonde, and INUENDO
p. 1348 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | The Role of Inflammatory Mediators in the Synergistic Toxicity of Ozone and 1-Nitronaphthalene in Rat Airways
Kara R. Schmelzer, Åsa M. Wheelock, Katja Dettmer, Dexter Morin, and Bruce D. Hammock
p. 1354 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Lung Cancer Attributable to Indoor Radon Exposure in France: Impact of the Risk Models and Uncertainty Analysis
Olivier Catelinois, Agnès Rogel, Dominique Laurier, Solenne Billon, Denis Hemon, Pierre Verger, and Margot Tirmarche
p. 1361 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Apoptosis and Bax Expression are Increased by Coal Dust in the Polycyclic Aromatic Hydrocarbon–Exposed Lung
Mohamed M. Ghanem, Lori A. Battelli, Robert R. Mercer, James F. Scabilloni, Michael L. Kashon, Jane Y.C. Ma, Joginder Nath, and Ann F. Hubbs
p. 1367 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | GIS Approaches for the Estimation of Residential-Level Ambient PM Concentrations
Duanping Liao, Donna J. Peuquet, Yinkang Duan, Eric A. Whitsel, Jianwei Dou, Richard L. Smith, Hung-Mo Lin, Jiu-Chiuan Chen, and Gerardo Heiss
p. 1374 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Airborne Mold and Endotoxin Concentrations in New Orleans, Louisiana, after Flooding, October through November 2005
Gina M. Solomon, Mervi Hjelmroos-Koski, Miriam Rotkin-Ellman, and S. Katharine Hammond
p. 1381 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Lung Toxicity of Ambient Particulate Matter from Southeastern U.S. Sites with Different Contributing Sources: Relationships between Composition and Effects
JeanClare Seagrave, Jacob D. McDonald, Edward Bedrick, Eric S. Edgerton, Andrew P. Gigliotti, John J. Jansen, Lin Ke, Luke P. Naeher, Steven K. Seilkop, Mei Zheng, and Joe L. Mauderly
p. 1387 [ Abstract ] [ Full ] [ PDF ]
TOXICOLOGY | Use of a Physiologically Based Pharmacokinetic Model for Rats to Study the Influence of Body Fat Mass and Induction of CYP1A2 on the Pharmacokinetics of TCDD
Claude Emond, Linda S. Birnbaum, and Michael J. DeVito
p. 1394 [ Abstract ] [ Full ] [ PDF ]
CELL CYCLE CONTROL | Exit from Arsenite-Induced Mitotic Arrest Is p53 Dependent
Samuel C. McNeely, Xiaogiang Xu, B. Frazier Taylor, Wolfgang Zacharias, Michael J. McCabe Jr., and J. Christopher States
p. 1401 [ Abstract ] [ Full ] [ PDF ]
POPULATION HEALTH | Meeting Report: Development of Environmental Health Indicators in Brazil and Other Countries in the Americas
Fernando F. Carneiro, Mara Lúcia C. Oliveira, Guilherme F. Netto, Luis A.C. Galvão, Jacira A. Cancio, Estela M. Bonini, Carlos F. Corvalan, and the Participants in the International Symposium on the Development of Indicators for Environmental Health Integrated Management
p. 1407 [ Abstract ] [ Full ] [ PDF ]
Environmental Medicine
RESPIRATORY DISEASE | Experimental PVC Material Challenge in Subjects with Occupational PVC Exposure
Anneli Tuomainen, Harri Stark, Markku Seuri, Maija-Riitta Hirvonen, Markku Linnainmaa, Anne Sieppi, and Hannu Tukiainen
p. 1409 [ Abstract ] [ Full ] [ PDF ]
Children's Health
INFECTIOUS DISEASE | Traffic-Related Air Pollution and Otitis Media
Michael Brauer, Ulrike Gehring, Bert Brunekreef, Johan de Jongste, Jorrit Gerritsen, Maroeska Rovers, Heinz-Erich Wichmann, Alet Wijga, and Joachim Heinrich
Also see Science Selections, p. A544
p. 1414 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | A Longitudinal Approach to Assessing Urban and Suburban Children's Exposure to Pyrethroid Pesticides
Chensheng Lu, Dana B. Barr, Melanie Pearson, Scott Bartell, and Roberto Bravo
Also see Science Selections, p. A544
p. 1419 [ Abstract ] [ Full ] [ PDF ]
EXPOSURE ASSESSMENT | Exposure to Phthalates in Neonatal Intensive Care Unit Infants: Urinary Concentrations of Monoesters and Oxidative Metabolites
Jennifer Weuve, Brisa N. Sánchez, Antonia M. Calafat, Ted Schettler, Ronald A. Green, Howard Hu, and Russ Hauser
p. 1424 [ Abstract ] [ Full ] [ PDF ]
RESPIRATORY DISEASE | Lung Radiology and Pulmonary Function of Children Chronically Exposed to Air Pollution
Lilian Calderón-Garcidueñas, Antonieta Mora-Tiscareño, Lynn A. Fordham, Charles J. Chung, Gildardo Valencia-Salazar, Silvia Flores-Gómez, Anna C. Solt, Alberto Gomez-del Campo, Ricardo Jardón-Torres, Carlos Henríquez-Roldán, Milan J. Hazucha, and William Reed
p. 1432 [ Abstract ] [ Full ] [ PDF ]
NEUROBEHAVIORAL DISEASE | Autism Spectrum Disorders in Relation to Distribution of Hazardous Air Pollutants in the San Francisco Bay Area
Gayle C. Windham, Lixia Zhang, Robert Gunier, Lisa A. Croen, and Judith K. Grether
p. 1438 [ Abstract ] [ Full ] [ PDF ]
Mini-Monograph
RISK ASSESSMENT | Key Scientific Issues in the Health Risk Assessment of Trichloroethylene
Weihsueh A. Chiu, Jane C. Caldwell, Nagalakshmi Keshava, and Cheryl Siegel Scott
p. 1445 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Issues in the Pharmacokinetics of Trichloroethylene and Its Metabolites
Weihsueh A. Chiu, Miles S. Okino, John C. Lipscomb, and Marina V. Evans
p. 1450 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Key Issues in the Modes of Action and Effects of Trichloroethylene Metabolites for Liver and Kidney Tumorigenesis
Jane C. Caldwell and Nagalakshmi Keshava
p. 1457 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Key Issues in the Role of Peroxisome Proliferator–Activated Receptor Agonism and Cell Signaling in Trichloroethylene Toxicity
Nagalakshmi Keshava and Jane C. Caldwell
p. 1464 [ Abstract ] [ Full ] [ PDF ]
RISK ASSESSMENT | Trichloroethylene Cancer Epidemiology: A Consideration of Select Issues
Cheryl Siegel Scott and Weihsueh A. Chiu
p. 1471 [ Abstract ] [ Full ] [ PDF ]
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