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Environ Health Perspect; DOI:10.1289/EHP424

Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge

Vicki Stone,1 Mark R. Miller,2 Martin J.D. Clift,3,4 Alison Elder,5 Nicholas L. Mills,2 Peter Møller,6 Roel P.F. Schins,7 Ulla Vogel,8,9 Wolfgang G. Kreyling,10 Keld Alstrup Jensen,8 Thomas A.J. Kuhlbusch,11,12 Per E. Schwarze,13 Peter Hoet,14 Antonio Pietroiusti,15 Andrea De Vizcaya-Ruiz,16 Armelle Baeza-Squiban,17 C. Lang Tran,18 and Flemming R. Cassee19,20
Author Affiliations open
1Institute of Biological Chemistry, Biophysics and Bioengineering, Heriot-Watt University, Edinburgh, Scotland, UK; 2Centre for Cardiovascular Science, University of Edinburgh, UK; 3Adolphe Merkle Institute, University of Fribourg, Switzerland; 4Swansea University Medical School, Singleton Park Campus, Swansea, Wales, UK; 5University of Rochester Medical Center, Rochester, NY; 6Department of Public Health, University of Copenhagen, Denmark; 7IUF Leibniz-Institut für umweltmedizinische Forschung, Düsseldorf, Germany; 8National Research Centre for the Working Environment, Copenhagen, Denmark; 9Department of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark; 10Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Munich, Germany; 11IUTA, Air Quality & Sustainable Nanotechnology Unit, Duisburg, Germany; 12Federal Institute of Occupational Safety and Health, Friedrich-Henkel-Weg, Duisburg, Germany; 13Norwegian Institute of Public Health, Oslo, Norway; 14Center for Environment and Health, KU Leuven, Leuven, Belgium; 15Department of Biomedicine and Prevention, University of Rome Tor Vergata, Italy; 16Departmento de Toxicología, CINVESTAV-IPN México City, México; 17Diderot University, Sorbonne Paris Cité, Paris, France; 18Institute of Occupational Medicine, Edinburgh, UK; 19National Institute for Public Health and the Environment, Bilthoven, Netherlands; 20Institute of Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands

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  • Background: A rich literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), with strong support for an important role for ultrafine (nano-sized) particles. At present, relatively little human health or epidemiology data exists for engineered nanomaterials (NM) despite clear parallels in their physicochemical properties and biological actions in in vitro models.

    Objectives: NMs are available in a range of physicochemical characteristics which allow a more systematic toxicological analysis. Therefore, the study of ultrafine particles (UFP, <100 nm in diameter) provides an opportunity to identify plausible health effects for NM, while the study of NM provides an opportunity to facilitate the understanding of the mechanism of toxicity of UFP.

    Methods: A workshop of experts systematically analysed the information available and identified 19 key Lessons that can facilitate knowledge exchange between these discipline areas.

    Discussion: Key lessons range from the availability of specific techniques and standard protocols for physicochemical characterization and toxicology assessment, to understanding and defining dose and the molecular mechanisms of toxicity. This review identifies a number of key areas where additional research prioritisation would facilitate both research fields simultaneously.

    Conclusion: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.

  • This EHP Advance Publication article has been peer-reviewed, revised, and accepted for publication. EHP Advance Publication articles are completely citable using the DOI number assigned to the article. This document will be replaced with the copyedited and formatted version as soon as it is available. Through the DOI number used in the citation, you will be able to access this document at each stage of the publication process.

    Citation: Stone V, Miller MR, Clift MJ, Elder A, Mills NL, Møller P, Schins RP, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TA, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR. Nanomaterials vs Ambient Ultrafine Particles: an Opportunity to Exchange Toxicology Knowledge. Environ Health Perspect; http://dx.doi.org/10.1289/EHP424

    Received: 17 December 2015
    Revised: 12 August 2016
    Accepted: 30 August 2016
    Published: 4 November 2016

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