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Science Selection Volume 123 | 2015

Environ Health Perspect; DOI:10.1289/ehp.123-A68

Air Pollution and ASDs: Homing In on an Environmental Risk Factor

Carrie Arnold is a freelance science writer living in Virginia. Her work has appeared in Scientific American, Discover, New Scientist, Smithsonian, and more.

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Citation: Arnold C. 2015. Air pollution and ASDs: homing in on an environmental risk factor. Environ Health Perspect 123:A68;

News Topics: Air Pollution, Children’s Health, Neurologic Health, Particulate Matter (PM), Risk Assessment

Published: 1 March 2015

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Related EHP Article

Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case–Control Analysis within the Nurses’ Health Study II Cohort

Raanan Raz, Andrea L. Roberts, Kristen Lyall, Jaime E. Hart, Allan C. Just, Francine Laden, and Marc G. Weisskopf

Although researchers have begun making significant inroads into understanding the genetic and biological basis for autism spectrum disorders (ASDs) and other neurodevelopmental disorders, it’s been estimated that environmental factors could account for just over half the risk of developing ASDs.1 In this issue of EHP, researchers have used data from 1,767 women in the Nurses’ Health Study (NHS) II to study exposure to particulate matter (PM) as one potential environmental risk factor for ASDs.2

In one of the first reports of a relationship between air pollution and ASDs, investigators in California found associations between estimated exposures to airborne heavy metals and other pollutants and risk of ASDs.3 Later studies using the same exposure models as the California study reported links between multiple hazardous air pollutants and ASDs in North Carolina and West Virginia,4 and a U.S.-wide study had similar findings.5 Other work considered how close pregnant women lived to freeways,6 or used monitor-based estimates of air pollutants7,8,9 or models of traffic-related exposures to study links with ASD risk.

Pregnant woman exercising in a city parkIn this study, higher exposures to PM2.5 air pollution during the third trimester of pregnancy were associated with increased risk of having a child with an autism spectrum disorder.

© KidStock/Blend Images/Corbis

“All these studies seemed to be circling around different aspects of air pollution but showing similar signals,” says Marc Weisskopf, an epidemiologist at Harvard and senior author of the current study. “We wanted to look at this in a U.S.-wide population with better models and with more precision.”

The current study included 245 mothers of children with ASDs and 1,522 controls. The researchers used each mother’s mailing address from before, during, and after pregnancy to estimate her exposure to airborne coarse and fine particulate matter (PM10 and PM2.5, respectively). Spatiotemporal models took into account data from the U.S. Environmental Protection Agency’s Air Quality System and other monitors along with geographic predictors such as proximity to major roads to estimate exposures on a monthly basis at the nurses’ residences.10,11,12

The coarser fraction of PM showed no clear relationship with ASD risk. However, the researchers estimated 50% higher odds of having a child with an ASD in women in the highest quartile of estimated PM2.5 exposure throughout pregnancy, compared with women in the lowest quartile, after controlling for child sex, month and year of birth, maternal and paternal age at birth, and median census tract income. In particular, the researchers found that the association between ASDs and exposure to PM2.5 was strongest during the third trimester of pregnancy.2

“This study provides some really nice continuing evidence of the potential relationship between air pollution and autism across the entire United States,” says Heather Volk, an epidemiologist at the University of Southern California, who was not involved in the study.

Previous work in animal models has suggested a possible mechanism for how air pollution exposure may increase ASD risk. Mice exposed to concentrated ambient ultrafine PM showed ventriculomegaly, altered neurochemistry, and activation of glial cells in the brain.13 These responses, which occurred preferentially in male mice, signal an inflammatory response. Weisskopf says that an inflammatory response in the mother or developing fetus is currently a leading hypothesis for how PM may increase ASD risk.

But any environmental risk, researchers say, almost certainly interacts with genetic factors that either increase or decrease ASD risk. “In a complex disease like autism, it’s not going to be just genes or just environment,” Volk says.


1. Hallmayer J, et al. Genetic heritability and shared environmental factors among twin pairs with autism. Arch Gen Psychiatry 68(11):1095–1102 (2011); doi: 10.1001/archgenpsychiatry.2011.76.

2. Raz R, et al. Autism spectrum disorder and particulate matter air pollution before, during, and after pregnancy: a nested case–control analysis within the Nurses’ Health Study II Cohort. Environ Health Perspect 123(3):264–270 (2015); doi: 10.1289/ehp.1408133.

3. Windham GC, et al. Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco Bay area. Environ Health Perspect 114(9):1438–1444 (2006); doi: 10.1289/ehp.9120.

4. Kalkbrenner AE, et al. Perinatal exposure to hazardous air pollutants and autism spectrum disorders at age 8. Epidemiology 21(5):631–641 (2010); doi: 10.1097/EDE.0b013e3181e65d76.

5. Roberts AL, et al. Perinatal air pollutant exposures and autism spectrum disorder in the children of Nurses’ Health Study II participants. Environ Health Perspect 121(8):978–984 (2013); doi: 10.1289/ehp.1206187.

6. Volk HE, et al. Residential proximity to freeways and autism in the CHARGE study. Environ Health Perspect 119(6):873–877 (2010); doi: 10.1289/ehp.1002835.

7. Volk HE, et al. Traffic-related air pollution, particulate matter, and autism. JAMA Psychiatry 70(1):71–77 (2013); doi: 10.1001/jamapsychiatry.2013.266.

8. Becerra TA, et al. Ambient air pollution and autism in Los Angeles County, California. Environ Health Perspect 121(3):380–386 (2013); doi: 10.1289/ehp.1205827.

9. von Ehrenstein OS, et al. In utero exposure to toxic air pollutants and risk of childhood autism. Epidemiology 25(6):851–858 (2014); doi: 10.1097/EDE.0000000000000150.

10. Yanosky JD, et al. Spatio-temporal modeling of particulate air pollution in the conterminous United States using geographic and meteorological predictors. Environ Health 13:63 (2014); doi: 10.1186/1476-069X-13-63.

11. Yanosky JD, et al. Spatio-temporal modeling of chronic PM10 exposure for the Nurses’ Health Study. Atmos Environ 42(18):4047–4062 (2008); doi: 10.1016/j.atmosenv.2008.01.044.

12. Yanosky JD, et al. Predicting chronic fine and coarse particulate exposures using spatiotemporal models for the northeastern and midwestern United States. Environ Health Perspect 117(4):522–529 (2009); doi: 10.1289/ehp.11692.

13. Allen JL, et al. Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice. Environ Health Perspect 122(9):939–945 (2014); doi: 10.1289/ehp.1307984.

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