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Correspondence September 2013 | Volume 121 | Issue 9

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Environ Health Perspect; DOI:Environ Health Perspect; DOI:10.1289/ehp.1307083R

Arsenic Levels in Chicken: Nachman et al. Respond

Keeve E. Nachman,1,2,3 Patrick A. Baron,1,2 Georg Raber,4 Kevin A. Francesconi,4 and David C. Love1,2
1Johns Hopkins Center for a Livable Future, 2Department of Environmental Health Sciences, and 3Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA; 4Institute of Chemistry, Karl-Franzens University, Graz, Austria
About This Article open

Citation: Nachman KE, Baron PA, Raber G, Francesconi KA, Love DC. Arsenic levels in chicken: Nachman et al. respond. Environ Health Perspect 121:A267–A268 (2013);

Address correspondence to K.E. Nachman, E-mail:

The authors declare they have no actual or potential competing financial interests.

Published: 1 September 2013

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In our paper (Nachman et al. 2013) we focused on dietary arsenic exposure from the use of arsenic-based drugs in food animal production, specifically chicken. We thank Lasky for broadening the discussion on arsenic regulations for food to include federal agencies beyond the Food and Drug Administration (FDA).

The results of our study (Nachman et al. 2013) indicate that the use of arsenic-based drugs increases the levels of inorganic arsenic in chicken meat. Based on these findings, we recommend banning the use of arsenic-based drugs in food animal production, which are under the jurisdiction of the FDA. It is important, however, to recognize the potential role that could be played by the U.S. Department of Agriculture (USDA) Food Safety and Inspection Service (FSIS) under its National Residue Program (NRP).

Under its mandate, the NRP facilitates the monitoring of arsenic levels in poultry products and supports enforcement actions for animal products in violation of arsenic standards (USDA FSIS 2012). Unfortunately, the NRP faces constraints (in addition to those noted by Lasky) that limit its effectiveness (Silbergeld and Nachman 2008). The most important of these constraints is the current arsenic standard for meat, which was set before 1963 (FDA 1963) and does not account for recent epidemiologic research. In addition, the standard applies to total arsenic concentrations rather than to inorganic arsenic, the species of greatest health relevance. Because arsenic can be present in food in various forms that have widely varying toxicity, standards might need to be species specific.

The U.S. Environmental Protection Agency (EPA) is currently revising its toxicological assessment for inorganic arsenic (U.S. EPA 2010) as part of its Integrated Risk Information System (IRIS) program. The purpose of this revision is to produce health-based guidance that can be useful in setting arsenic standards in different media (including foods) that reflect our current understanding of dose–response relationships between arsenic exposures and adverse health outcomes. To achieve this goal, coordination between the FDA, U.S. EPA, and NRP is essential. By applying appropriate standards and methods with adequate sensitivity for the arsenic species of interest, the NRP could play a central role in minimizing dietary exposure to arsenic through animal products.

Although sale of roxarsone remains suspended in the United States, nitarsone, a chemically similar arsenical drug, continues to be sold (Zoetis 2013). Industry statements in the media have confirmed nitarsone use in the turkey industry (Aubrey 2013), and the USDA estimates of per capita turkey consumption are increasing (USDA 2013). Research is needed to characterize potential contributions of nitarsone to inorganic arsenic concentrations in turkey meat. For these reasons, monitoring efforts remain relevant. In the absence of regulations that limit inorganic arsenic in our foods, the banning of arsenic-based drugs would minimize dietary arsenic exposures in poultry consumers.


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FDA (Food and Drug Administration). 1963. Food additives resulting from contact with containers or equipment and food additives otherwise affecting food. Fed Reg 28:10871.

Nachman KE, Baron PA, Raber G, Francesconi KA, Navas-Acien A, Love DC. 2013. Roxarsone, inorganic arsenic, and other arsenic species in chicken: a U.S.-based market basket sample. Environ Health Perspect 121:818–824; doi:10.1289/ehp.1206245.

Silbergeld EK, Nachman K. 2008. The environmental and public health risks associated with arsenical use in animal feeds. Ann NY Acad Sci 1140(1):346–357.

USDA (U.S. Department of Agriculture) FSIS (Food Safety and Inspection Service). 2012. National Residue Program for Meat, Poultry, and Egg Products: 2012 Residue Sampling Plans. Available:​ook.pdf [accessed 13 June 2013].

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U.S. EPA (U.S. Environmental Protection Agency). 2010. IRIS Toxicological Review of Inorganic Arsenic (Cancer) (2010 External Review Draft). EPA/635/R-10/001. Washington, DC:U.S. EPA. Available: recordisplay.cfm?deid=219111 [accessed 24 October 2012].

Zoetis. 2013. Histostat Type A Medicated Article. Available:​Pages/Histostat.aspx [accessed 12 June 2013].

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