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Environmental Health Perspectives

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April 2010 | Volume 118 | Number 4




Focus_TOCA Matter Of Degrees: Advancing Our Understanding of Acrylamide

Angela Spivey
a160–a167 |

A complex chemical process known as the Maillard reaction is responsible for the delectably browned surfaces, fragrant aromas, and toxic by-products produced by several cooking methods.



White House Proposes Healthy Food Financing Initiative

David C. Holzman
a156–a156 |


Will Ocean Acidification Erode the Base of the Food Web?

Carol Potera
a157–a157 |


Secondhand Smoke Exposure May Alter Fetal Blood Pressure Programming

Adrian Burton
a158–a159 |


The Beat

Erin E. Dooley
a158–a159 |

Spheres of Influence


Spheres_TOCMystery in a Bottle: Will the EPA Require Public Disclosure of Inert Pesticide Ingredients?

Bob Weinhold
a168–a171 |

For nearly two-thirds of a century, up to 99% of the ingredients in any given pesticide product have legally been hidden from public view, even though many are known to be toxic. The primary impetus has been to protect industry trade secrets. But the U.S. Environmental Protection Agency (EPA) is considering what it calls a “sea change” in policy, possibly requiring public disclosure of 100% of a pesticide product’s ingredients.

Science Selections


ToxCast on Target: In Vitro Assays and Computer Modeling Show Promise for Screening Chemicals

Rebecca Clay Haynes
a172–a172 |


Attention-Worthy Association: Prenatal Phthalate Exposure and Later Child Behavior

Julia R. Barrett
a172–a172 |


Brain Drain? PBDEs Alter Development of Human Brain Cells

Kellyn S. Betts
a173–a173 |


Chew on This: Persistent Organic Pollutants May Promote Insulin Resistance Syndrome

Tanya Tillett
a173–a173 |



Polyethylene Terephthalate May Yield Endocrine Disruptors

Leonard Sax
445–448 |



Short-Term Effects of PM10 and NO2 on Respiratory Health among 
Children with Asthma or Asthma-like Symptoms: A Systematic Review 
and Meta-Analysis

Gudrun Weinmayr, Elisa Romeo, Manuela De Sario, Stephan K. Weiland, Francesco Forastiere
449–457 |


Dioxin-Induced Changes in Epididymal Sperm Count and Spermatogenesis

Warren G. Foster, Serena Maharaj-Briceño, Daniel G. Cyr
458–464 |



Persistent Organic Pollutant Exposure Leads to Insulin Resistance Syndrome

Jérôme Ruzzin, Rasmus Petersen, Emmanuelle Meugnier, Lise Madsen, Erik-Jan Lock, Haldis Lillefosse, Tao Ma, Sandra Pesenti, Si Brask Sonne, Troels Torben Marstrand, Marian Kjellevold Malde, Zhen-Yu Du, Carine Chavey, Lluis Fajas, Anne-Katrine Lundebye, Christian Lehn Brand, Hubert Vidal, Karsten Kristiansen, Livar Frøyland
465–471 |


Effects of Diisononyl Phthalate on Atopic Dermatitis in Vivo and Immunologic Responses in Vitro

Eiko Koike, Rie Yanagisawa, Kaori Sadakane, Ken-ichiro Inoue, Takamichi Ichinose, Hirohisa Takano
472–478 |


Polychlorinated Biphenyls Disrupt Blood–Brain Barrier Integrity and 
Promote Brain Metastasis Formation

Melissa Seelbach, Lei Chen, Anita Powell, Yean Jung Choi, Bei Zhang, Bernhard Hennig, Michal Toborek
479–484 |


In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

Richard S. Judson, Keith A. Houck, Robert J. Kavlock, Thomas B. Knudsen, Matthew T. Martin, Holly M. Mortensen, David M. Reif, Daniel M. Rotroff, Imran Shah, Ann M. Richard, David J. Dix
485–492 |


Particulate Matter Oxidative Potential from Waste Transfer 
Station Activity

Krystal J. Godri, Sean T. Duggan, Gary W. Fuller, Tim Baker, David Green, Frank J. Kelly, Ian S. Mudway
493–498 |


Case Report: Lung Disease in World Trade Center Responders 
Exposed to Dust and Smoke: Carbon Nanotubes Found in the Lungs 
of World Trade Center Patients and Dust Samples

Maoxin Wu, Ronald E. Gordon, Robin Herbert, Maria Padilla, Jacqueline Moline, David Mendelson, Virginia Litle, William D. Travis, Joan Gil
499–504 |


Interaction of Stress, Lead Burden, and Age on Cognition in Older Men: 
The VA Normative Aging Study

Junenette L. Peters, Marc G. Weisskopf, Avron Spiro, Joel Schwartz, David Sparrow, Huiling Nie, Howard Hu, Robert O. Wright, Rosalind J. Wright
505–510 |


Associations between Polycyclic Aromatic Hydrocarbon–Related Exposures and p53 Mutations in Breast Tumors

Irina Mordukhovich, Pavel Rossner, Mary Beth Terry, Regina Santella, Yu-Jing Zhang, Hanina Hibshoosh, Lorenzo Memeo, Mahesh Mansukhani, Chang-Min Long, Gail Garbowski, Meenakshi Agrawal, Mia M. Gaudet, Susan E. Steck, Sharon K. Sagiv, Sybil M. Eng, Susan L. Teitelbaum, Alfred I. Neugut, Kathleen Conway-Dorsey, Marilie D. Gammon
511–518 |


Bromination Pattern of Hydroxylated Metabolites of BDE-47 Affects 
Their Potency to Release Calcium from Intracellular Stores in PC12 Cells

Milou M.L. Dingemans, Harm J. Heusinkveld, Åke Bergman, Martin van den Berg, Remco H.S. Westerink
519–525 |


Flexible Meta-Regression to Assess the Shape of the Benzene–Leukemia Exposure–Response Curve

Jelle Vlaanderen, Lützen Portengen, Nathaniel Rothman, Qing Lan, Hans Kromhout, Roel Vermeulen
526–532 |


Impact of Smoking and Chewing Tobacco on Arsenic-Induced 
Skin Lesions

Anna-Lena Lindberg, Nazmul Sohel, Mahfuzar Rahman, Lars Åke Persson, Marie Vahter
533–538 |


Exposure to Phthalates and Breast Cancer Risk in Northern Mexico

Lizbeth López-Carrillo, Raúl U. Hernández-Ramírez, Antonia M. Calafat, Luisa Torres-Sánchez, Marcia Galván-Portillo, Larry L. Needham, Rubén Ruiz-Ramos, Mariano E. Cebrián
539–544 |


Zebrafish Seizure Model Identifies p,p´-DDE as the Dominant Contaminant 
of Fetal California Sea Lions That Accounts for Synergistic Activity with Domoic Acid

Jessica A. Tiedeken, John S. Ramsdell
545–551 |


Low Levels of the Herbicide Atrazine Alter Sex Ratios and Reduce Metamorphic Success in Rana pipiens Tadpoles Raised in Outdoor Mesocosms

Valérie S. Langlois, Amanda C. Carew, Bruce D. Pauli, Michael G. Wade, Gerard M. Cooke, Vance L. Trudeau
552–557 |


Tuberculosis and Indoor Biomass and Kerosene Use in Nepal: 
A Case–Control Study

Amod K. Pokhrel, Michael N. Bates, Sharat C. Verma, Hari S. Joshi, Chandrashekhar T. Sreeramareddy, Kirk R. Smith
558–564 |

Children’s Health


Prenatal Phthalate Exposure Is Associated with Childhood Behavior and Executive Functioning

Stephanie M. Engel, Amir Miodovnik, Richard L. Canfield, Chenbo Zhu, Manori J. Silva, Antonia M. Calafat, Mary S. Wolff
565–571 |


Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption

Timm Schreiber, Kathrin Gassmann, Christine Götz, Ulrike Hübenthal, Michaela Moors, Guido Krause, Hans F. Merk, Ngoc-Ha Nguyen, Thomas S. Scanlan, Josef Abel, Christine R. Rose, Ellen Fritsche
572–578 |


Exposures to Particulate Matter and Polycyclic Aromatic Hydrocarbons and Oxidative Stress in Schoolchildren

Sanghyuk Bae, Xiao-Chuan Pan, Su-Young Kim, Kwangsik Park, Yoon-Hee Kim, Ho Kim, Yun-Chul Hong
579–583 |





Applying Research to Public Health Questions: Biologically Relevant Exposures

Linda S. Birnbaum
a152–a152 |



Hormesis: A Brief Reply to an Advocate

Paul Mushak
a153–a153 |


Hormesis: Calabrese Responds

Edward J. Calabrese
a153–a154 |


Lead in Drinking Water as a Public Health Challenge

Björn P. Zietz, Jessica Laß, Roland Suchenwirth, Hartmut Dunkelberg
a154–a155 |

Book Review


Book Review: Politics of China’s Environmental Protection: Problems and Progress

Changhua Wu
a178–a178 |

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