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Environmental Health Perspectives

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April 2014 | Volume 122 | Issue 4


April 2014 coverFocus

Lead-Based Decorative Paints: Where Are They Still Being Sold—and Why?

Rebecca Kessler | A96

Decades ago developed nations began banning lead-based paint for residential use, yet few developing countries regulate lead in paint at all. And decorative paints with high lead content are readily available on store shelves in these countries, rarely bearing any labeling to warn consumers of the dangers they pose, according to a spate of recent studies. Now, however, an international effort is gathering steam to remove lead from decorative paints once and for all.

Image: © Tim Gainey/Alamy

Aerial view of Navajo MineSpheres of Influence

Tribe at a Crossroads: The Navajo Nation Purchases a Coal Mine

Rebecca Fairfax Clay | A104

In December 2013 the Navajo Nation shifted for the first time from leasing all its coal-rich land to outside mining companies to purchasing one of its remaining surface coal mines, along with the associated assets and liabilities. The controversial purchase was a bid to stabilize the tribe’s economy, but critics believe the health and environmental costs of continued coal use will outweigh the economic benefits.

Image: © Bruce Dale/National Geographic Creative

Science Selections

Chinks in the Armor? Filaggrin-Depleted Skin Could Increase Environmental Exposures

Lindsey A. Konkel | A108

Also see Joensen et al., p. 345

Birth Defects and Mothers’ Proximity to Natural Gas Development: Is There a Connection?

Lindsey A. Konkel | A109

Also see McKenzie et al., p. 412

Apples to Apples: Comparing PM2.5 Exposures and Birth Outcomes in Understudied Countries

Julia R. Barrett | A110

Also see Fleischer et al., p. 425

Disease Burdens Associated with PM2.5 Exposure: How a New Model Provided Global Estimates

Carrie Arnold | A111

Also see Burnett et al., p. 397


Human Health Effects of Tetrachloroethylene: Key Findings and Scientific Issues

Kathryn Z. Guyton, Karen A. Hogan, Cheryl Siegel Scott, Glinda S. Cooper, Ambuja S. Bale, Leonid Kopylev, Stanley Barone Jr., Susan L. Makris, Barbara Glenn, Ravi P. Subramaniam, Maureen R. Gwinn, Rebecca C. Dzubow, and Weihsueh A. Chiu | 325


The Societal Costs and Benefits of Commuter Bicycling: Simulating the Effects of Specific Policies Using System Dynamics Modeling

Alexandra Macmillan, Jennie Connor, Karen Witten, Robin Kearns, David Rees, and Alistair Woodward | 335

Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men

Ulla Nordström Joensen, Niels Jørgensen, Michael Meldgaard, Hanne Frederiksen, Anna-Maria Andersson, Torkil Menné, Jeanne Duus Johansen, Berit Christina Carlsen, Steen Stender, Pal Bela Szecsi, Niels Erik Skakkebæk, Ewa Rajpert-De Meyts, and Jacob P. Thyssen | 345

Also see Science Selections, p. A108

Urinary Concentrations of 2,4-Dichlorophenol and 2,5-Dichlorophenol in the U.S. Population (National Health and Nutrition Examination Survey, 2003–2010): Trends and Predictors

Xiaoyun Ye, Lee-Yang Wong, Xiaoliu Zhou, and Antonia M. Calafat | 351

Transgenic Zebrafish Reveal Tissue-Specific Differences in Estrogen Signaling in Response to Environmental Water Samples

Daniel A. Gorelick, Luke R. Iwanowicz, Alice L. Hung, Vicki S. Blazer, and Marnie E. Halpern | 356

Cadmium Exposure and Cancer Mortality in a Prospective Cohort: The Strong Heart Study

Esther García-Esquinas, Marina Pollan, Maria Tellez-Plaza, Kevin A. Francesconi, Walter Goessler, Eliseo Guallar, Jason G. Umans, Jeunliang Yeh, Lyle G. Best, and Ana Navas-Acien | 363

A Unique Co-culture Model for Fundamental and Applied Studies of Human Fetoplacental Steroidogenesis and Interference by Environmental Chemicals

Andrée-Anne Hudon Thibeault, Kathy Deroy, Cathy Vaillancourt, and J. Thomas Sanderson | 371

Air Pollution Exposure and Abnormal Glucose Tolerance during Pregnancy: The Project Viva Cohort

Abby F. Fleisch, Diane R. Gold, Sheryl L. Rifas-Shiman, Petros Koutrakis, Joel D. Schwartz, Itai Kloog, Steven Melly, Brent A. Coull, Antonella Zanobetti, Matthew W. Gillman, and Emily Oken | 378

Bisphenol A Exposure and Cardiac Electrical Conduction in Excised Rat Hearts

Nikki Gillum Posnack, Rafael Jaimes III, Huda Asfour, Luther M. Swift, Anastasia M. Wengrowski, Narine Sarvazyan, and Matthew W. Kay | 384

Differential Effects of Source-Specific Particulate Matter on Emergency Hospitalizations for Ischemic Heart Disease in Hong Kong

Vivian Chit Pun, Ignatius Tak-sun Yu, Kin-fai Ho, Hong Qiu, Zhiwei Sun, and Linwei Tian | 391

An Integrated Risk Function for Estimating the Global Burden of Disease Attributable to Ambient Fine Particulate Matter Exposure

Richard T. Burnett, C. Arden Pope III, Majid Ezzati, Casey Olives, Stephen S. Lim, Sumi Mehta, Hwashin H. Shin, Gitanjali Singh, Bryan Hubbell, Michael Brauer, H. Ross Anderson, Kirk R. Smith, John R. Balmes, Nigel G. Bruce, Haidong Kan, Francine Laden, Annette Prüss-Ustün, Michelle C. Turner, Susan M. Gapstur, W. Ryan Diver, and Aaron Cohen | 397

Also see Science Selections, p. A111

Association of Long-Term Exposure to Traffic-Related Air Pollution with Blood Pressure and Hypertension in an Adult Population–Based Cohort in Spain (the REGICOR Study)

Maria Foraster, Xavier Basagaña, Inmaculada Aguilera, Marcela Rivera, David Agis, Laura Bouso, Alexandre Deltell, Jaume Marrugat, Rafel Ramos, Jordi Sunyer, Joan Vila, Roberto Elosua, and Nino Künzli | 404

Children’s Health

Birth Outcomes and Maternal Residential Proximity to Natural Gas Development in Rural Colorado

Lisa M. McKenzie, Ruixin Guo, Roxana Z. Witter, David A. Savitz, Lee S. Newman, and John L. Adgate | 412

Also see Science Selections, p. A109

GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study

Elaina A. MacIntyre, Michael Brauer, Erik Melén, Carl Peter Bauer, Mario Bauer, Dietrich Berdel, Anna Bergström, Bert Brunekreef, Moira Chan-Yeung, Claudia Klümper, Elaine Fuertes, Ulrike Gehring, Anna Gref, Joachim Heinrich, Olf Herbarth, Marjan Kerkhof, Gerard H. Koppelman, Anita L. Kozyrskyj, Göran Pershagen, Dirkje S. Postma, Elisabeth Thiering, Carla M.T. Tiesler, and Christopher Carlsten, for the TAG Study Group | 418

Outdoor Air Pollution, Preterm Birth, and Low Birth Weight: Analysis of the World Health Organization Global Survey on Maternal and Perinatal Health

Nancy L. Fleischer, Mario Merialdi, Aaron van Donkelaar, Felipe Vadillo-Ortega, Randall V. Martin, Ana Pilar Betran, João Paulo Souza, and Marie S. O´Neill | 425

Also see Science Selections, p. A110



Letter from the Editor-in-Chief

Hugh A. Tilson | A88


Prenatal PCB-153 Exposure and Decreased Birth Weight: The Role of Gestational Weight Gain

Eva Govarts, Maribel Casas, Greet Schoeters, Merete Eggesbø, Damaskini Valvi, Mark Nieuwenhuijsen, and Jens Peter Bonde, on behalf of the ENRIECO, OBELIX, and CHICOS Consortia | A89

Prenatal PCB-153 Exposure and Decreased Birth Weight: Verner et al. Respond

Marc-André Verner, Melvin E. Andersen, Harvey J. Clewell III, and Matthew P. Longnecker | A89

Crystallographic Analysis and Mimicking of Estradiol Binding: Interpretation and Speculation

Thomas G. Osimitz, Michael L. Dourson, A. Wallace Hayes, and Sam Kacew | A91

Crystallographic Analysis and Mimicking of Estradiol Binding: Pedersen et al. Respond

Lars C. Pedersen, Linda S. Birnbaum, Rajendrakumar A. Gosavi, and Gabriel A. Knudsen | A91


Erratum: “Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?”


Erratum: Erratum for Johnson et al. [Environ Health Perspect 113:A18 (2005)]


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