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Children’s Health Collection 2014

The Children’s Health Collection comprises peer-reviewed research articles, reviews, commentaries, editorials, news, and Science Selections published in EHP from October 2013 through September 2014 (

  • CH Collection Cover 2014Children’s Health Collection 2014 comprises abstracts of all relevant articles published in EHP from October 2013 through September 2014: peer-reviewed research articles, news features, Science Selections, and editorials. Abstracts are featured for each research article, and hyperlinks take readers directly to the full article online ( The Science Selections are noted just below the related research.

    As in previous Collections, the three main sections—Disease Outcomes, Exposures, and Methodologies and Populations—contain all research that has appeared in the Children’s Health section of each EHP issue as well as relevant reviews and commentaries, research that involves both adult and child cohorts and both animal and human components, adult diseases with fetal or childhood origins, experimental models with direct application to children’s health, and topics of general interest to children’s health researchers and advocates. Some specific topics (e.g., Built Environment, Climate Change) are featured in news articles but not research.

    In this Collection, air pollutants, heavy metals, and chemical compounds continue to be heavily represented in the research, with a wide variety of outcomes (e.g., lung disfunction, congenital anomalies, developmental and behavioral issues, hormone levels) and modes of transfer (e.g., placenta, breast milk, diet, air, soil). A new category is Eyes and Ears, which reflects increased interest in the role of noise pollution in disease and hearing loss. In addition to single longitudinal birth cohorts, larger studies that combine multiple cohorts (e.g., ESCAPE, HELIX, NewGeneris) contribute databases, methodologies, and analyses of multiple environmental factors and outcomes.

    Please see for all the yearly Children’s Health collections. This collection is also available as a 4.6MB PDF.

    Martha M. Dimes, PhD
    Children’s Health Editor

  • Asthma/Respiratory Disease, Lung Development, Allergy open

    Air Pollution Exposure and Lung Function in Children: The ESCAPE Project

    Ulrike Gehring, Olena Gruzieva, Raymond M. Agius, Rob Beelen, Adnan Custovic, Josef Cyrys, Marloes Eeftens, Claudia Flexeder, Elaine Fuertes, Joachim Heinrich, Barbara Hoffmann, Johan C. de Jongste, Marjan Kerkhof, Claudia Klümper, Michal Korek, Anna Mölter, Erica S. Schultz, Angela Simpson, Dorothea Sugiri, Magnus Svartengren, Andrea von Berg, Alet H. Wijga, Göran Pershagen, and Bert Brunekreef

    Air Pollution and Respiratory Infections during Early Childhood: An Analysis of 10 European Birth Cohorts within the ESCAPE Project

    Elaina A. MacIntyre, Ulrike Gehring, Anna Mölter, Elaine Fuertes, Claudia Klümper, Ursula Krämer, Ulrich Quass, Barbara Hoffmann, Mireia Gascon, Bert Brunekreef, Gerard H. Koppelman, Rob Beelen, Gerard Hoek, Matthias Birk, Johan C. de Jongste, H.A. Smit, Josef Cyrys, Olena Gruzieva, Michal Korek, Anna Bergström, Raymond M. Agius, Frank de Vocht, Angela Simpson, Daniela Porta, Francesco Forastiere, Chiara Badaloni, Giulia Cesaroni, Ana Esplugues, Ana Fernández-Somoano, Aitana Lerxundi, Jordi Sunyer, Marta Cirach, Mark J. Nieuwenhuijsen, Göran Pershagen, and Joachim Heinrich

    GSTP1 and TNF Gene Variants and Associations between Air Pollution and Incident Childhood Asthma: The Traffic, Asthma and Genetics (TAG) Study

    Elaina A. MacIntyre, Michael Brauer, Erik Melén, Carl Peter Bauer, Mario Bauer, Dietrich Berdel, Anna Bergström, Bert Brunekreef, Moira Chan-Yeung, Claudia Klümper, Elaine Fuertes, Ulrike Gehring, Anna Gref, Joachim Heinrich, Olf Herbarth, Marjan Kerkhof, Gerard H. Koppelman, Anita L. Kozyrskyj, Göran Pershagen, Dirkje S. Postma, Elisabeth Thiering, Carla M.T. Tiesler, and Christopher Carlsten, for the TAG Study Group

    Influence of Urbanicity and County Characteristics on the Association between Ozone and Asthma Emergency Department Visits in North Carolina

    Jason D. Sacks, Ana G. Rappold, J. Allen Davis Jr., David B. Richardson, Anna E. Waller, and Thomas J. Luben

    Neurodevelopment/Neurobehavior open

    Domain-Specific Effects of Prenatal Exposure to PCBs, Mercury, and Lead on Infant Cognition: Results from the Environmental Contaminants and Child Development Study in Nunavik

    Olivier Boucher, Gina Muckle, Joseph L. Jacobson, R. Colin Carter, Melissa Kaplan-Estrin, Pierre Ayotte, Éric Dewailly, and Sandra W. Jacobson

    Prenatal Phthalate Exposures and Neurobehavioral Development Scores in Boys and Girls at 6–10 Years of Age

    Roni W. Kobrosly, Sarah Evans, Amir Miodovnik, Emily S. Barrett, Sally W. Thurston, Antonia M. Calafat, and Shanna H. Swan

    Prenatal Polybrominated Diphenyl Ether Exposures and Neurodevelopment in U.S. Children through 5 Years of Age: The HOME Study

    Aimin Chen, Kimberly Yolton, Stephen A. Rauch, Glenys M. Webster, Richard Hornung, Andreas Sjödin, Kim N. Dietrich, and Bruce P. Lanphear

    Autism open

    Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study

    Joseph M. Braun, Amy E. Kalkbrenner, Allan C. Just, Kimberly Yolton, Antonia M. Calafat, Andreas Sjödin, Russ Hauser, Glenys M. Webster, Aimin Chen, and Bruce P. Lanphear

    Cancers open

    Domestic Radon Exposure and Risk of Childhood Cancer: A Prospective Census-Based Cohort Study

    Dimitri Hauri, Ben Spycher, Anke Huss, Frank Zimmermann, Michael Grotzer, Nicolas von der Weid, Damien Weber, Adrian Spoerri, Claudia E. Kuehni, and Martin Röösli, for the Swiss National Cohort and the Swiss Paediatric Oncology Group (SPOG)

    Childhood Cancer and Traffic-Related Air Pollution Exposure in Pregnancy and Early Life

    Julia E. Heck, Jun Wu, Christina Lombardi, Jiaheng Qiu, Travis J. Meyers, Michelle Wilhelm, Myles Cockburn, and Beate Ritz

    Birth Defects open

    Anogenital Distance and Penile Length in Infants with Hypospadias or Cryptorchidism: Comparison with Normative Data

    Ajay Thankamony, Ngee Lek, Dan Carroll, Martyn Williams, David B. Dunger, Carlo L. Acerini, Ken K. Ong, and Ieuan A. Hughes

    Traffic-Related Air Pollution and Congenital Anomalies in Barcelona

    Anna Schembari, Mark J. Nieuwenhuijsen, Joaquin Salvador, Audrey de Nazelle, Marta Cirach, Payam Dadvand, Rob Beelen, Gerard Hoek, Xavier Basagaña, and Martine Vrijheid

    Birth Outcomes and Maternal Residential Proximity to Natural Gas Development in Rural Colorado

    Lisa M. McKenzie, Ruixin Guo, Roxana Z. Witter, David A. Savitz, Lee S. Newman, and John L. Adgate

    Maternal Exposure to Criteria Air Pollutants and Congenital Heart Defects in Offspring: Results from the National Birth Defects Prevention Study

    Jeanette A. Stingone, Thomas J. Luben, Julie L. Daniels, Montserrat Fuentes, David B. Richardson, Arthur S. Aylsworth, Amy H. Herring, Marlene Anderka, Lorenzo Botto, Adolfo Correa, Suzanne M. Gilboa, Peter H. Langlois, Bridget Mosley, Gary M. Shaw, Csaba Siffel, Andrew F. Olshan, and the National Birth Defects Prevention Study

    Eyes and Ears open

    NEWS | Myopia: The Evidence for Environmental Factors

    Tim Lougheed

    Myopia, or nearsightedness, was long blamed on genetics and behavior, but dramatic increases in prevalence in recent decades point to environmental factors as well. Moreover, time spent outdoors appears to have a protective effect against myopia, although investigators still aren’t sure why.

    NEWS | Wind Turbines: A Different Breed
    of Noise?

    Nate Seltenrich

    Wind turbines in Falmouth, Massachusetts
    Since at least 1930, researchers have amassed a body of evidence on the adverse nonauditory health effects of environmental noise. More recently, a new source of noise has entered the scene: wind turbines. As wind farms become more common near populated areas, researchers are investigating the unique qualities of the noise they produce.
    © David L Ryan/The Boston Globe via Getty Images

    Environmental Noise Pollution in the United States: Developing an Effective Public Health Response

    Monica S. Hammer, Tracy K. Swinburn, and Richard L. Neitzel
    NEWS | Science Selection
    Fighting Noise Pollution: A Public Health Strategy
    David C. Holzman

    Pregnancy Outcomes: Preterm Birth/Small for Gestational Age/Birth Weight/Fetal Development open

    Bulky DNA Adducts in Cord Blood, Maternal Fruit-and-Vegetable Consumption, and Birth Weight in a European Mother–Child Study (NewGeneris)

    Marie Pedersen, Bernadette Schoket, Roger W. Godschalk, John Wright, Hans von Stedingk, Margareta Törnqvist, Jordi Sunyer, Jeanette K. Nielsen, Domenico F. Merlo, Michelle A. Mendez, Helle M. Meltzer, Viktória Lukács, Anette Landström, Soterios A. Kyrtopoulos, Katalin Kovács, Lisbeth E. Knudsen, Margaretha Haugen, Laura J. Hardie, Kristine B. Gützkow, Sarah Fleming, Eleni Fthenou, Peter B. Farmer, Aina Espinosa, Leda Chatzi, Gunnar Brunborg, Nigel J. Brady, Maria Botsivali, Khelifa Arab, Lívia Anna, Jan Alexander, Silvia Agramunt, Jos C. Kleinjans, Dan Segerbäck, and Manolis Kogevinas
    NEWS | Science Selection
    Prenatal Protection: Maternal Diet May Modify Impact of PAHs
    Julia R. Barrett

    Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005–2010

    Lyndsey A. Darrow, Cheryl R. Stein, and Kyle Steenland

    Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?

    Marc-André Verner, Robin McDougall, Anders Glynn, Melvin E. Andersen, Harvey J. Clewell III, and Matthew P. Longnecker

    Outdoor Air Pollution, Preterm Birth, and Low Birth Weight: Analysis of the World Health Organization Global Survey on Maternal and Perinatal Health

    Nancy L. Fleischer, Mario Merialdi, Aaron van Donkelaar, Felipe Vadillo-Ortega, Randall V. Martin, Ana Pilar Betran, João Paulo Souza, and Marie S. O´Neill

    Gestational Weight Gain and Exposure of Newborns to Persistent Organic Pollutants

    Esther Vizcaino, Joan O. Grimalt, Berit Glomstad, Ana Fernández-Somoano, and Adonina Tardón

    Exposure to Fine Particulate Matter during Pregnancy and Risk of Preterm Birth among Women in New Jersey, Ohio, and Pennsylvania, 2000–2005

    Kristen M. Rappazzo, Julie L. Daniels, Lynne C. Messer, Charles Poole, and Danelle T. Lobdell

    Infections open

    NEWS | Rethinking Sterile: The Hospital Microbiome

    Carrie Arnold

    Hospital in-patient surrounded by flowers, cards, and balloons
    Hospitals, despite the historical emphasis on sterility of health care environments, are now understood to be microbial ecosystems unto themselves. Investigators are studying these hospital microbiomes with an eye toward reducing hospital-acquired infections and optimizing patient health.
    © BSIP/Science Source

    Associations between Extreme Precipitation and Gastrointestinal-Related Hospital Admissions in Chennai, India

    Kathleen F. Bush, Marie S. O’Neill, Shi Li, Bhramar Mukherjee, Howard Hu, Santu Ghosh, and Kalpana Balakrishnan

    Fetal or Early-life Exposures Contributing to Adult Disease open

    Serum Dioxin Concentrations and Bone Density and Structure in the Seveso Women’s Health Study

    Brenda Eskenazi, Marcella Warner, Marcella Sirtori, Thomas Fuerst, Stephen A. Rauch, Paolo Brambilla, Paolo Mocarelli, and Alessandro Rubinacci

    Maternal Concentrations of Persistent Organochlorine Pollutants and the Risk of Asthma in Offspring: Results from a Prospective Cohort with 20 Years of Follow-up

    Susanne Hansen, Marin Strøm, Sjurdur F. Olsen, Ekaterina Maslova, Panu Rantakokko, Hannu Kiviranta, Dorte Rytter, Bodil H. Bech, Linda V. Hansen, and Thorhallur I. Halldorsson

    Obesity open

    Urinary Polycyclic Aromatic Hydrocarbons and Childhood Obesity: NHANES (2001–2006)

    Franco Scinicariello and Melanie C. Buser

    Differences in BMI z-Scores between Offspring of Smoking and Nonsmoking Mothers: A Longitudinal Study of German Children from Birth through 14 Years of Age

    Christina Riedel, Nora Fenske, Manfred J. Müller, Sandra Plachta-Danielzik, Thomas Keil, Linus Grabenhenrich, and Rüdiger von Kries
  • Heavy Metals (e.g., Lead, Mercury) open

    NEWS | Lead-Based Decorative Paints: Where Are They Still Sold—and Why?

    Rebecca Kessler

    Decades ago developed nations began banning lead-based paint for residential use, yet few developing countries regulate lead in paint at all. And decorative paints with high lead content are readily available on store shelves in these countries, rarely bearing any labeling to warn consumers of the dangers they pose, according to a spate of recent studies. Now, however, an international effort is gathering steam to remove lead from decorative paints once and for all.

    NEWS | Low-Dose Arsenic: In Search of a Risk Threshold

    Charles W. Schmidt

    Exposure to harmful levels of arsenic may be more widespread than previously recognized. Protecting against low-level exposure is challenging, however, given arsenic’s ubiquity. Moreover, disagreement over the evidence for low-dose effects poses a problem for regulators who face mounting pressure to set or reduce standards for arsenic.

    NEWS | The Minamata Convention on Mercury: A First Step toward Protecting Future Generations

    Rebecca Kessler

    Minamata disease patient with doctor
    The Minamata disaster was the first large-scale incident of methylmercury poisoning, and it drew the world’s attention to the devastating effects of this powerful neurotoxicant, now known to be particularly dangerous to fetuses, infants, and young children. In October 2013 a new convention to control mercury emissions opens for signing in Japan in recognition of the fact that mercury pollution is a global problem no one country can solve alone.
    © Chris Steele-Perkins/Magnum Photos

    EDITORIAL | Childhood Lead Poisoning in China: Challenges and Opportunities

    Chong-huai Yan, Jian Xu, and Xiao-ming Shen

    Dietary Predictors of Maternal Prenatal Blood Mercury Levels in the ALSPAC Birth Cohort Study

    Jean Golding, Colin D. Steer, Joseph R. Hibbeln, Pauline M. Emmett, Tony Lowery, and Robert Jones

    Maternal Blood, Plasma, and Breast Milk Lead: Lactational Transfer and Contribution to Infant Exposure

    Adrienne S. Ettinger, Ananya Roy, Chitra J. Amarasiriwardena, Donald Smith, Nicola Lupoli, Adriana Mercado-García, Hector Lamadrid-Figueroa, Martha Maria Tellez-Rojo, Howard Hu, and Mauricio Hernández-Avila

    Mercury Exposure and Health Impacts among Individuals in the Artisanal and Small-Scale Gold Mining Community: A Comprehensive Review

    Herman Gibb and Keri Grace O’Leary

    The Influence of Declining Air Lead Levels on Blood Lead–Air Lead Slope Factors in Children

    Jennifer Richmond-Bryant, Qingyu Meng, Allen Davis, Jonathan Cohen, Shou-En Lu, David Svendsgaard, James S. Brown, Lauren Tuttle, Heidi Hubbard, Joann Rice, Ellen Kirrane, Lisa C. Vinikoor-Imler, Dennis Kotchmar, Erin P. Hines, and Mary Ross

    Pesticides and Other Chemicals/Compounds
    (e.g., BPA, PCBs, PBDEs, PFCs, Phthalates, Endocrine Disruptors) open

    Phthalate Exposure and Allergy in the U.S. Population: Results from NHANES 2005–2006

    Jane A. Hoppin, Renee Jaramillo, Stephanie J. London, Randi J. Bertelsen, Päivi M. Salo, Dale P. Sandler, and Darryl C. Zeldin

    Prenatal Exposure to Environmental Phenols: Concentrations in Amniotic Fluid and Variability in Urinary Concentrations during Pregnancy

    Claire Philippat, Mary S. Wolff, Antonia M. Calafat, Xiaoyun Ye, Rebecca Bausell, Molly Meadows, Joanne Stone, Rémy Slama, and Stephanie M. Engel

    Predictors of Serum Chlorinated Pesticide Concentrations among Prepubertal Russian Boys

    Thuy Lam, Paige L. Williams, Jane S. Burns, Oleg Sergeyev, Susan A. Korrick, Mary M. Lee, Linda S. Birnbaum, Boris Revich, Larisa M. Altshul, Donald G. Patterson Jr., Wayman E. Turner, and Russ Hauser

    Urinary Metabolites of Organophosphate and Pyrethroid Pesticides and Behavioral Problems in Canadian Children

    Youssef Oulhote and Maryse F. Bouchard

    Evaluation of Polycyclic Aromatic Hydrocarbons Using Analytical Methods, Toxicology, and Risk Assessment Research: Seafood Safety after a Petroleum Spill as an Example

    Jeffrey Wickliffe, Edward Overton, Scott Frickel, Jessi Howard, Mark Wilson, Bridget Simon, Stephen Echsner, Daniel Nguyen, David Gauthe, Diane Blake, Charles Miller, Cornelis Elferink, Shakeel Ansari, Harshica Fernando, Edward Trapido, and Andrew Kane

    Exposure to Brominated Trihalomethanes in Water During Pregnancy and Micronuclei Frequency in Maternal and Cord Blood Lymphocytes

    Leslie Thomas Stayner, Marie Pedersen, Evridiki Patelarou, Ilse Decordier, Kim Vande Loock, Leda Chatzi, Ana Espinosa, Eleni Fthenou, Mark J. Nieuwenhuijsen, Esther Gracia-Lavedan, Euripides G. Stephanou, Micheline Kirsch-Volders, and Manolis Kogevinas

    Evaluating the Effectiveness of Fish Consumption Advisories: Modeling Prenatal, Postnatal, and Childhood Exposures to Persistent Organic Pollutants

    Matthew J. Binnington, Cristina L. Quinn, Michael S. McLachlan, and Frank Wania

    Breastfeeding: A Potential Excretion Route for Mothers and Implications for Infant Exposure to Perfluoroalkyl Acids

    Debapriya Mondal, Rosana Hernandez Weldon, Ben G. Armstrong, Lorna J. Gibson, Maria-Jose Lopez-Espinosa, Hyeong-Moo Shin, and Tony Fletcher

    Within- and Between-Child Variation in Repeated Urinary Pesticide Metabolite Measurements over a 1-Year Period

    Kathleen R. Attfield, Michael D. Hughes, John D. Spengler, and Chensheng Lu

    Temporal Trends in Phthalate Exposures: Findings from the National Health and Nutrition Examination Survey, 2001–2010

    Ami R. Zota, Antonia M. Calafat, and Tracey J. Woodruff

    Behavioral Sexual Dimorphism in School-Age Children and Early Developmental Exposure to Dioxins and PCBs: A Follow-Up Study of the Duisburg Cohort

    Gerhard Winneke, Ulrich Ranft, Jürgen Wittsiepe, Monika Kasper-Sonnenberg, Peter Fürst, Ursula Krämer, Gabriele Seitner, and Michael Wilhelm

    Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene (p,p’-DDE) with Testosterone Levels in Adolescent Males

    Lawrence M. Schell, Mia V. Gallo, Glenn D. Deane, Kyrie R. Nelder, Anthony P. DeCaprio, Agnes Jacobs, and the Akwesasne Task Force on the Environment

    Urinary Concentrations of 2,4-Dichlorophenol and 2,5-Dichlorophenol in the U.S. Population (National Health and Nutrition Examination Survey, 2003–2010): Trends and Predictors

    Xiaoyun Ye, Lee-Yang Wong, Xiaoliu Zhou, and Antonia M. Calafat

    Association between Maternal Serum Perfluoroalkyl Substances during Pregnancy and Maternal and Cord Thyroid Hormones: Taiwan Maternal and Infant Cohort Study

    Yan Wang, Walter J. Rogan, Pau-Chung Chen, Guang-Wen Lien, Hsiao-Yen Chen, Ying-Chih Tseng, Matthew P. Longnecker, and Shu-Li Wang

    Predictors of Blood Trihalomethane Concentrations in NHANES 1999–2006

    Anne M. Riederer, Radhika Dhingra, Benjamin C. Blount, and Kyle Steenland

    Bisphenol A and Reproductive Health: Update of Experimental and Human Evidence, 2007–2013

    Jackye Peretz, Lisa Vrooman, William A. Ricke, Patricia A. Hunt, Shelley Ehrlich, Russ Hauser, Vasantha Padmanabhan, Hugh S. Taylor, Shanna H. Swan, Catherine A. VandeVoort, and Jodi A. Flaws

    A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

    Hanne Frederiksen, Tanja Kuiri-Hänninen, Katharina M. Main, Leo Dunkel, and Ulla Sankilampi

    Air Pollution: Particulate Matter/Smoke/Indoor Air open

    NEWS | Take Care in the Kitchen: Avoiding Cooking-Related Pollutants

    Nate Seltenrich

    Frying pan over gas burner
    The process of cooking food and even simply operating stoves—particularly gas appliances—can emit several potentially hazardous chemicals and compounds. Investigators suggest a few simple techniques to reduce exposure while they look for better ways to control emissions.
    © Photocuisine/Alamy

    Health and Household Air Pollution from Solid Fuel Use: The Need for Improved Exposure Assessment

    Maggie L. Clark, Jennifer L. Peel, Kalpana Balakrishnan, Patrick N. Breysse, Steven N. Chillrud, Luke P. Naeher, Charles E. Rodes, Alan F. Vette, and John M. Balbus

    Long-term Exposure to PM10 and NO2 in Association with Lung Volume and Airway Resistance in the MAAS Birth Cohort

    Anna Mölter, Raymond M. Agius, Frank de Vocht, Sarah Lindley, William Gerrard, Lesley Lowe, Danielle Belgrave, Adnan Custovic, and Angela Simpson

    Ambient Air Pollution and Preeclampsia: A Spatiotemporal Analysis

    Payam Dadvand, Francesc Figueras, Xavier Basagaña, Rob Beelen, David Martinez, Marta Cirach, Anna Schembari, Gerard Hoek, Bert Brunekreef, and Mark J. Nieuwenhuijsen

    Pollutant Exposures from Natural Gas Cooking Burners: A Simulation-Based Assessment for Southern California

    Jennifer M. Logue, Neil E. Klepeis, Agnes B. Lobscheid, and Brett C. Singer

    Enablers and Barriers to Large-Scale Uptake of Improved Solid Fuel Stoves: A Systematic Review

    Eva A. Rehfuess, Elisa Puzzolo, Debbi Stanistreet, Daniel Pope, and Nigel G. Bruce

    Outdoor Formaldehyde and NO2 Exposures and Markers of Genotoxicity in Children Living Near Chipboard Industries

    Alessandro Marcon, Maria Enrica Fracasso, Pierpaolo Marchetti, Denise Doria, Paolo Girardi, Linda Guarda, Giancarlo Pesce, Vanda Pironi, Paolo Ricci, and Roberto de Marco

    Climate Change open

    EDITORIAL | Climate Change and Public Health in North Carolina: A Unique State Offers a Unique Perspective

    Leah Devlin, Mikey Goralnik, William G. Ross Jr., and Kimberly Thigpen Tart

    Radiation open

    NEWS | Once Upon a Mine: The Legacy of Uranium on the Navajo Nation

    Carrie Arnold

    The Navajo Nation is home to hundreds of abandoned uranium mines, ranging from small holes dug by a single prospector into the side of a mesa to large commercial mining operations. Within decades of the arrival of prospectors in the 1940s, Navajo miners were being diagnosed with lung cancer, a relatively rare disease in this largely nonsmoking population. Today the Navajo population remains at high risk for kidney disease as a result of uranium exposure, as well as potentially associated hypertension, cardiovascular disease, and autoimmune diseases.

    Guidelines for Exposure Assessment in Health Risk Studies Following a Nuclear Reactor Accident

    André Bouville, Martha S. Linet, Maureen Hatch, Kiyohiko Mabuchi, and Steven L. Simon

    Assessment of the Risk of Medium-Term Internal Contamination in Minamisoma City, Fukushima, Japan, after the Fukushima Dai-ichi Nuclear Accident

    Amina Sugimoto, Stuart Gilmour, Masaharu Tsubokura, Shuhei Nomura, Masahiro Kami, Tomoyoshi Oikawa, Yukio Kanazawa, and Kenji Shibuya

    Built Environment open

    NEWS | Urban Gardening: Managing the Risks of Contaminated Soil

    Rebecca Kessler

    Gardener’s boots
    The urban decay of the middle and late twentieth century has given way to a gardening revival in cities around the globe. But urban soils are often heavily contaminated with metals, polycyclic aromatic hydrocarbons, and other contaminants, prompting questions about the health consequences of urban gardening—and some new solutions.
    © Paul Burns/Corbis

  • Epigenetics, Exposome, Biomarkers open

    NEWS | Uncertain Inheritance: Transgenerational Effects of Environmental Exposures

    Charles W. Schmidt

    Stacking dolls
    Animal studies have reported transgenerational effects for chemicals including permethrin, DEET, bisphenol A, a number of phthalates, dioxin, jet fuel mixtures, nicotine, and tributyltin, among others. Although no human data yet exist for effects to the F3 generation, several studies have documented multigenerational chemical impacts, and the new findings are spurring a reevaluation of how scientists perceive environmental health threats.
    © Emilio Ereza/Alamy

    The Human Early-Life Exposome (HELIX): Project Rationale and Design

    Martine Vrijheid, Rémy Slama, Oliver Robinson, Leda Chatzi, Muireann Coen, Peter van den Hazel, Cathrine Thomsen, John Wright, Toby J. Athersuch, Narcis Avellana, Xavier Basagaña, Celine Brochot, Luca Bucchini, Mariona Bustamante, Angel Carracedo, Maribel Casas, Xavier Estivill, Lesley Fairley, Diana van Gent, Juan R. Gonzalez, Berit Granum, Regina Gražulevicˇiene˙, Kristine B. Gutzkow, Jordi Julvez, Hector C. Keun, Manolis Kogevinas, Rosemary R.C. McEachan, Helle Margrete Meltzer, Eduard Sabidó, Per E. Schwarze, Valérie Siroux, Jordi Sunyer, Elizabeth J. Want, Florence Zeman, and Mark J. Nieuwenhuijsen
    NEWS | Science Selection
    The HELIX Project: Tracking the Exposome in Real Time
    Carol Potera

    Micronuclei in Cord Blood Lymphocytes and Associations with Biomarkers of Exposure to Carcinogens and Hormonally Active Factors, Gene Polymorphisms, and Gene Expression: The NewGeneris Cohort

    Domenico Franco Merlo, Silvia Agramunt, Lívia Anna, Harrie Besselink, Maria Botsivali, Nigel J. Brady, Marcello Ceppi, Leda Chatzi, Bowang Chen, Ilse Decordier, Peter B. Farmer, Sarah Fleming, Vincenzo Fontana, Asta Försti, Eleni Fthenou, Fabio Gallo, Panagiotis Georgiadis, Hans Gmuender, Roger W. Godschalk, Berit Granum, Laura J. Hardie, Kari Hemminki, Kevin Hochstenbach, Lisbeth E. Knudsen, Manolis Kogevinas, Katalin Kovács, Soterios A. Kyrtopoulos, Martinus Løvik, Jeanette K Nielsen, Unni Cecilie Nygaard, Marie Pedersen, Per Rydberg, Bernadette Schoket, Dan Segerbäck, Rajinder Singh, Jordi Sunyer, Margareta Törnqvist, Henk van Loveren, Frederik J. van Schooten, Kim Vande Loock, Hans von Stedingk, John Wright, Jos C. Kleinjans, Micheline Kirsch-Volders, Joost H.M. van Delft, and the NewGeneris Consortium

    Methodologies open

    A Unique Co-culture Model for Fundamental and Applied Studies of Human Fetoplacental Steroidogenesis and Interference by Environmental Chemicals

    Andrée-Anne Hudon Thibeault, Kathy Deroy, Cathy Vaillancourt, and J. Thomas Sanderson
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