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Environmental Health Perspectives

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Featured Children’s Health Articles

From the EHP Editors

Exposures to environmental contaminants during critical windows of development can alter the course of normal development, with lifelong health consequences. Beaudin et al. used a rat model to demonstrate that early-life exposures to low levels of manganese affected adult behaviors such as attention and impulse control. These findings provide the biological plausibility that motivates further epidemiologic research on how manganese might alter neurodevelopment in children.

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© pixdeluxe/iStockphoto

Photo of a doctor checking blood pressure of a patient
© AndreyPopov/iStockphoto

Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice

From the EHP Editors

In malaria-endemic regions of the world, DDT is still used to control the mosquitoes that spread this devastating disease. However, benefits of DDT spraying may be offset by risks to human health, especially when exposures occur during early life. La Merrill et al. used a mouse model to show that perinatal exposure to DDT causes hypertension later in life. Further, the same medication used to treat hypertension in humans was effective in lowering blood pressure in these mice, pointing to the underlying mechanism. Evidence from this study strengthens the need to protect pregnant women from DDT exposures.

From the EHP Editors

Smoking during pregnancy is known to adversely affect lung development in the fetus and add to the risk of respiratory disease risk later life. But does smoking during adolescence add to this risk? Drummond et al. addressed this question using a mouse model. They found that mice exposed to cigarette smoke prenatally and during adolescence fared worse than those exposed only in utero. This research further supports the importance of efforts to prevent teen smoking.

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Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice

First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls
Perfluoroalkyl Substances during Pregnancy and Offspring Weight and Adiposity at Birth: Examining Mediation by Maternal Fasting Glucose in the Healthy Start Study
The Joint Effect of Prenatal Exposure to Metal Mixtures on Neurodevelopmental Outcomes at 20–40 Months of Age: Evidence from Rural Bangladesh
Ambient Temperature and Stillbirth: A Multi-Center Retrospective Cohort Study
Associations of Prenatal Urinary Bisphenol A Concentrations with Child Behaviors and Cognitive Abilities
Maternal and Cord Blood Manganese Concentrations and Early Childhood Neurodevelopment among Residents near a Mining-Impacted Superfund Site
Humoral Immunity in Arsenic-Exposed Children in Rural Bangladesh: Total Immunoglobulins and Vaccine-Specific Antibodies
Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and Maternal Prepregnancy Obesity on Childhood Overweight or Obesity
Manganese in Drinking Water and Cognitive Abilities and Behavior at 10 Years of Age: A Prospective Cohort Study
Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations in Fuzhou, China: A Retrospective Case-Control Study
Levels and Determinants of DDT and DDE Exposure in the VHEMBE Cohort

Current Children's Health Articles

Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children’s Environmental Health Studies: The Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group
The Prevalence of Antibiotic-Resistant Staphylococcus aureus Nasal Carriage among Industrial Hog Operation Workers, Community Residents, and Children Living in Their Households: North Carolina, USA
Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study

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