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Environmental Health Perspectives

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Featured Children’s Health Articles

From the EHP Editors

Exposures to environmental contaminants during critical windows of development can alter the course of normal development, with lifelong health consequences. Beaudin et al. used a rat model to demonstrate that early-life exposures to low levels of manganese affected adult behaviors such as attention and impulse control. These findings provide the biological plausibility that motivates further epidemiologic research on how manganese might alter neurodevelopment in children.

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Perinatal DDT Exposure Induces Hypertension and Cardiac Hypertrophy in Adult Mice

From the EHP Editors

In malaria-endemic regions of the world, DDT is still used to control the mosquitoes that spread this devastating disease. However, benefits of DDT spraying may be offset by risks to human health, especially when exposures occur during early life. La Merrill et al. used a mouse model to show that perinatal exposure to DDT causes hypertension later in life. Further, the same medication used to treat hypertension in humans was effective in lowering blood pressure in these mice, pointing to the underlying mechanism. Evidence from this study strengthens the need to protect pregnant women from DDT exposures.

From the EHP Editors

Smoking during pregnancy is known to adversely affect lung development in the fetus and add to the risk of respiratory disease risk later life. But does smoking during adolescence add to this risk? Drummond et al. addressed this question using a mouse model. They found that mice exposed to cigarette smoke prenatally and during adolescence fared worse than those exposed only in utero. This research further supports the importance of efforts to prevent teen smoking.

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Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

Current Children's Health Articles

Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children’s Environmental Health Studies: The Children’s Environmental Health and Disease Prevention Research Center’s Epigenetics Working Group
The Prevalence of Antibiotic-Resistant Staphylococcus aureus Nasal Carriage among Industrial Hog Operation Workers, Community Residents, and Children Living in Their Households: North Carolina, USA
Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study

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