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Environmental Health Perspectives

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December 2012 | Volume 120 | Issue 12



120n12_Focus_toc_150pxHealthier Tribal Housing: Combining the Best of Old and New

Nate Seltenrich | A460-A469

A convergence of housing-related factors may be partly to blame for increased disease risks among Native Americans and Alaska Natives, including poorly constructed homes, poverty, overcrowding, a lack of consideration of climate, insufficient indoor ventilation, and use of wood-burning stoves. But if housing is a problem, it may also be a solution. Tribes across the country are now building healthier homes that combine traditional indigenous building methods and designs with modern green building techniques.


Global Trade Tradeoff: Rickettsial Disease in Taiwan

Sharon Levy | A456

Still Searching for Better Butter Flavoring

Carol Potera | A457

Organic Food Conclusions Don’t Tell the Whole Story

David C. Holzman | A458

The Beat

Erin Dooley | A459

On the Cover | Spheres of Influence

120n12_Spheres_toc_150pxProgress and Pollution: Port Cities Prepare for the Panama Canal Expansion

Andrea Hricko | A470-A473

The Panama Canal expansion, slated for completion by 2015, has sparked the competitive imagination of East Coast and Gulf Coast port authorities who hope to capture some of the 70% of U.S. imports currently controlled by West Coast ports. Experts at the U.S. Army Corps of Engineers call the Panama Canal expansion a likely “game changer” for U.S. trade, and container volumes at East Coast/Gulf Coast ports could more than double within the next two decades. But with this growth come questions about what major initiatives to expand cargo capacity could mean for public health in these port cities.

Science Selections

Potential Obesogen Identified: Fungicide Triflumizole Is Associated with Increased Adipogenesis in Mice

Valerie J. Brown | A474

Exposure Intimacy: A New Metric for Assessing Chemical Intake

Kellyn S. Betts | A474

Don’t Hold Your Breath: Indoor CO2 Exposure and Impaired Decision Making

Tanya Tillett | A475

Crispy Cravings May Affect Baby’s Health: Prenatal Acrylamide Exposure Is Associated with Reduced Birth Weight

Julia R. Barrett | A475


Molecular Mechanism of Acrylamide Neurotoxicity: Lessons Learned from Organic Chemistry

Richard M. LoPachin and Terrence Gavin | 1650-1657

Evaluation of the Association between Arsenic and Diabetes: A National Toxicology Program Workshop Review

Elizabeth A. Maull, Habibul Ahsan, Joshua Edwards, Matthew P. Longnecker, Ana Navas-Acien, Jingbo Pi, Ellen K. Silbergeld, Miroslav Styblo, Chin-Hsiao Tseng, Kristina A. Thayer, and Dana Loomis | 1658-1670


The Role of Ambient Ozone in Epidemiologic Studies of Heat-Related Mortality

Colleen E. Reid, Jonathan M. Snowden, Caitlin Kontgis, and Ira B. Tager | 1628-1630

Animal Use and Lessons Learned in the U.S. High Production Volume Chemicals Challenge Program

Patricia L. Bishop, Joseph R. Manuppello, Catherine E. Willett, and Jessica T. Sandler | 1631-1639

Consortium-Based Science: The NIEHS’s Multipronged, Collaborative Approach to Assessing the Health Effects of Bisphenol A

Linda S. Birnbaum, John R. Bucher, Gwen W. Collman, Darryl C. Zeldin, Anne F. Johnson, Thaddeus T. Schug, and Jerrold J. Heindel | 1640-1644

Indigenous Peoples of North America: Environmental Exposures and Reproductive Justice

Elizabeth Hoover, Katsi Cook, Ron Plain, Kathy Sanchez, Vi Waghiyi, Pamela Miller, Renee Dufault, Caitlin Sislin, and David O. Carpenter | 1645-1649


Is CO2 an Indoor Pollutant? Direct Effects of Low-to-Moderate CO2 Concentrations on Human Decision-Making Performance

Usha Satish, Mark J. Mendell, Krishnamurthy Shekhar, Toshifumi Hotchi, Douglas Sullivan, Siegfried Streufert, and William J. Fisk | 1671-1677

Intake to Production Ratio: A Measure of Exposure Intimacy for Manufactured Chemicals

William Nazaroff, Charles J. Weschler, John C. Little, and Elaine A. Cohen Hubal | 1678-1683

Exposure of Rats to Environmental Tobacco Smoke during Cerebellar Development Alters Behavior and Perturbs Mitochondrial Energetics

Brian F. Fuller, Diego F. Cortes, Miranda K. Landis, Hiyab Yohannes, Hailey E. Griffin, Jillian E. Stafflinger, M. Scott Bowers, Mark H. Lewis, Michael A. Fox, and Andrew K. Ottens | 1684-1691

Hyaluronan Activation of the Nlrp3 Inflammasome Contributes to the Development of Airway Hyperresponsiveness

Feifei Feng, Zhuowei Li, Erin N. Potts-Kant, Yiming Wu, W. Michael Foster, Kristi L. Williams, and John W. Hollingsworth | 1692-1698

Environmental Inequality in Exposures to Airborne Particulate Matter Components in the United States

Michelle L. Bell and Keita Ebisu | 1699-1704

Dose Reconstruction of Di(2-ethylhexyl) Phthalate Using a Simple Pharmacokinetic Model

Matthew Lorber and Antonia M. Calafat | 1705-1710

Rodent Thyroid, Liver, and Fetal Testis Toxicity of the Monoester Metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a Novel Brominated Flame Retardant Present in Indoor Dust

Cecilia Springer, Edward Dere, Susan J. Hall, Elizabeth V. McDonnell, Simon C. Roberts, Craig M. Butt, Heather M. Stapleton, Deborah J. Watkins, Michael D. McClean, Thomas F. Webster, Jennifer J. Schlezinger, and Kim Boekelheide | 1711-1719

Triflumizole Is an Obesogen in Mice that Acts through Peroxisome Proliferator Activated Receptor Gamma (PPARγ)

Xia Li, Hang T. Pham, Amanda S. Janesick, and Bruce Blumberg | 1720-1726

Comparison of Geostatistical Interpolation and Remote Sensing Techniques for Estimating Long-Term Exposure to Ambient PM2.5 Concentrations across the Continental United States

Seung-Jae Lee, Marc L. Serre, Aaron van Donkelaar, Randall V. Martin, Richard T. Burnett, and Michael Jerrett | 1727-1732

Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh

Wei Jie Seow, Wen-Chi Pan, Molly L. Kile, Andrea A. Baccarelli, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mahiuddin, Golam Mostofa, Xihong Lin, and David C. Christiani | 1733-1738

Children’s Health

Birth Weight, Head Circumference, and Prenatal Exposure to Acrylamide from Maternal Diet: The European Prospective Mother–Child Study (NewGeneris)

Marie Pedersen, Hans von Stedingk, Maria Botsivali, Silvia Agramunt, Jan Alexander, Gunnar Brunborg, Leda Chatzi, Sarah Fleming, Eleni Fthenou, Berit Granum, Kristine B. Gutzkow, Laura J. Hardie, Lisbeth E. Knudsen, Soterios A. Kyrtopoulos, Michelle A. Mendez, Domenico F. Merlo, Jeanette K. Nielsen, Per Rydberg, Dan Segerbäck, Jordi Sunyer, John Wright, Margareta Törnqvist, Jos C. Kleinjans, Manolis Kogevinas, and the NewGeneris Consortium | 1739-1745

Airborne PM2.5 Chemical Components and Low Birth Weight in the Northeastern and Mid-Atlantic Regions of the United States

Keita Ebisu and Michelle L. Bell | 1746-1752

Air Pollution Exposure and Markers of Placental Growth and Function: The Generation R Study

Edith H. van den Hooven, Frank H. Pierik, Yvonne de Kluizenaar, Albert Hofman, Sjoerd W. van Ratingen, Peter Y.J. Zandveld, Henk Russcher, Jan Lindemans, Henk M.E. Miedema, Eric A.P. Steegers, and Vincent W.V. Jaddoe | 1753-1759

Polybrominated Diphenyl Ethers (PBDEs) in Breast Milk and Neuropsychological Development in Infants

Mireia Gascon, Marta Fort, David Martínez, Anne-Elie Carsin, Joan Forns, Joan O. Grimalt, Loreto Santa Marina, Nerea Lertxundi, Jordi Sunyer, and Martine Vrijheid | 1760-1765



Calculation of Mercury’s Effects on Neurodevelopment

Philippe Grandjean, Celine Pichery, Martine Bellanger, Esben Budtz-Jørgensen | A452

Calculation of Mercury’s Effects on Neurodevelopment: Bellinger Responds

David C. Bellinger | A452

Estimating Risk of Circulatory Disease from Exposure to Low‑Level Ionizing Radiation

Helmut Schöllnberger, Jan Christian Kaiser | A452-A453

Estimating Risk of Circulatory Disease: Little et al. Respond

Mark P. Little, Dimitry Bazyka, Simon D. Bouffler, John D. Harrison, Elisabeth Cardis, Francis A. Cucinotta, Michaela Kreuzer, Olivier Laurent, Soile Tapio, Richard Wakeford, Lydia Zablotska, Steven E. Lipshultz | A453-A454

Is Ambient PM2.5 Sulfate Harmful?

Thomas Grahame, Richard Schlesinger | A454

Is Ambient PM2.5 Sulfate Harmful? Schwartz and Lepeule Respond

Joel Schwartz, Johanna Lepeule | A454-A455

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