Telomere Length and Air Pollution: Observations in Women Who Use Biomass Cookstoves
Telomeres, the DNA sequences that cap and protect chromosomes, lose base pairs with each new cell division.1 As telomeres shorten over time, chromosomes slowly degrade in one of several processes that contribute to cellular aging.2 Inflammation and oxidative stress—which are both triggered by air pollution—accelerate telomere shortening.3,4 Therefore, air pollution may speed cellular aging as well as the onset of chronic diseases that come with it. A study published recently in Environmental Health Perspectives has now provided evidence that indoor air pollution—in this case, associated with biomass cookstoves—may cause telomere shortening.5
“Our study is the first to show this association with household air pollution,” says Jill Baumgartner, an environmental epidemiologist at McGill University in Montreal, Canada, who led the research. “It’s significant given that biomass stove emissions affect nearly half the world’s population,6 and telomere shortening is potentially a very important indicator for long-term health.”
Baumgartner and her team performed the study in 12 rural villages in a mountainous rural area in Sichuan, China, which had been devastated by an earthquake in 2008. As part of a government-sponsored recovery program, local villagers had been supplied with indoor stoves that burn biomass. Residents burned mostly wood and crop residues in these stoves.
Baumgartner and her colleagues outfitted 137 local women (28–88 years of age) with wearable monitors to measure their personal exposures to black carbon and fine particulate matter (PM sub 2.5). Sooty black carbon derives mainly from incomplete combustion, whereas PM sub 2.5 has many potential combustion and noncombustion sources, including dust.
The research was limited to women because they are the primary cooks in this region and thus disproportionately exposed to stove emissions. This also prevented confounding from tobacco smoking, which in this area is a habit primarily among men.
Air monitoring took place during three sampling campaigns lasting 48 hours each, two in winter and one in summer. The women provided cheek swabs for DNA analysis. They also filled out questionnaires on their diets, alcohol use, tobacco smoke exposure, and several other potential confounders that also are associated with shortening of telomeres.
The monitoring showed that air pollution exposure levels varied widely: 13 to 1,136 micrograms per cubic meter (mean: 154 micrograms per cubic meter) for PM sub 2.5 and 0.1 to 34.0 micrograms per cubic meter (mean: 3.6 micrograms per cubic meter) for black carbon. Baumgartner says the highest exposures occurred episodically while the women were cooking. “After that, pollution concentrations would decrease to the levels detected in outdoor air, which are more stable but can still exceed WHO [World Health Organization] targets,” she says. The WHO has set an interim air quality target of 35 micrograms per cubic meter (annual average) for PM sub 2.5. There currently is no WHO target or guideline for black carbon.
The investigators estimated that each interquartile increase in both PM sub 2.5 and black carbon measures was associated with a shorter relative telomere length. Associations were generally consistent between younger and older women, women with higher and lower body mass index and waist circumference, and women with and without secondhand tobacco smoke exposure.
The new findings “confirm what we’ve seen in other studies7 showing that air pollution induces this particular response,” says Michael Brauer, a professor of occupational and environmental health at the University of British Columbia in Vancouver, Canada, who was not involved in the investigation. However, Brauer adds that further research is still needed to assess the clinical significance of telomere shortening on long-term health outcomes.
Maggie Clark, an assistant professor of epidemiology at Colorado State University in Fort Collins, who likewise was not involved in the study, calls the research an important contribution. “We often have limited resources to follow populations over time, and that makes predictive biomarkers attractive as surrogates for long-term health impacts,” she says.
Telomere shortening is potentially a good option for such a biomarker Clark says: “It is noninvasive—you just need a swab from the cheek—and it could potentially provide information about age-related conditions we think contribute most to the global burden of disease attributed to household air pollution.” The next step, she says, should be to determine if interventions that reduce household air exposures slow the rate at which telomeres shorten over time.
Bakaysa SL, Mucci LA, Slagboom PE, Boomsma DI, McClearn GE, Johansson B,2007. Telomere length predicts survival independent of genetic influences. Aging Cell 6(6):769–774, PMID: 17925004, 10.1111/j.1474-9726.2007.00340.x. Crossref, Medline, Google Scholar
Bernadotte A, Mikhelson VM, Spivak IM. 2016. Markers of cellular senescence: telomere shortening as a marker of cellular senescence. Aging (Albany NY) 8(1):3–11, PMID: 26805432, 10.18632/aging.100871. Crossref, Medline, Google Scholar
Monaghan P. 2010. Telomeres and life histories: the long and the short of it. Ann N Y Acad Sci 1206:130–142, PMID: 20860686, 10.1111/j.1749-6632.2010.05705.x. Crossref, Medline, Google Scholar
von Zglinicki T. 2002. Oxidative stress shortens telomeres. Trends Biochem Sci 27(7):339–344, PMID: 12114022, 10.1016/s0968-0004(02)02110-2. Crossref, Medline, Google Scholar
Li S, Yang M, Carter E, Schauer JJ, Yang X, Ezzati M,2019. Exposure–response associations of household air pollution and buccal cell telomere length in women using biomass stoves. Environ Health Perspect 127(8): 87004, PMID: 31393791, 10.1289/EHP4041. Link, Google Scholar
- 6. Health Effects Institute. 2019. State of Global Air 2019. Boston, MA: Health Effects Institute. https://www.stateofglobalair.org/sites/default/files/soga_2019_report.pdf [accessed
12 February 2020]. Google Scholar
Miri M, Nazarzadeh M, Alahabadi A, Ehrampoush MH, Rad A, Lotfi MH,2019. Air pollution and telomere length in adults: a systematic review and meta-analysis of observational studies. Environ Pollut 244:636–647, PMID: 30384069, 10.1016/j.envpol.2018.09.130. Crossref, Medline, Google Scholar