Increased risk of malignant mesothelioma of the pleura after residential or domestic exposure to asbestos: a case-control study in Casale Monferrato, Italy.
Publication: Environmental Health Perspectives
Volume 109, Issue 9
Pages 915 - 919
Abstract
The association of malignant mesothelioma (MM) and nonoccupational asbestos exposure is currently debated. Our study investigates environmental and domestic asbestos exposure in the city where the largest Italian asbestos cement (AC) factory was located. This population-based case-control study included pleural MM (histologically diagnosed) incidents in the area in 1987-1993, matched by age and sex to two controls (four if younger than 60). Diagnoses were confirmed by a panel of five pathologists. We interviewed 102 cases and 273 controls in 1993-1995, out of 116 and 330 eligible subjects. Information was checked and completed on the basis of factory and Town Office files. We adjusted analyses for occupational exposure in the AC industry. In the town there were no other relevant industrial sources of asbestos exposure. Twenty-three cases and 20 controls lived with an AC worker [odds ratio (OR) = 4.5; 95% confidence interval (CI), 1.8-11.1)]. The risk was higher for the offspring of AC workers (OR = 7.4; 95% CI, 1.9-28.1). Subjects attending grammar school in Casale also showed an increased risk (OR = 3.3; 95% CI, 1.4-7.7). Living in Casale was associated with a very high risk (after selecting out AC workers: OR = 20.6; 95% CI, 6.2-68.6), with spatial trend with increasing distance from the AC factory. The present work confirms the association of environmental asbestos exposure and pleural MM, controlling for other sources of asbestos exposure, and suggests that environmental exposure caused a greater risk than domestic exposure.
Formats available
You can view the full content in the following formats:
Information & Authors
Information
Published In
Environmental Health Perspectives
Volume 109 • Issue 9 • September 2001
Pages: 915 - 919
PubMed: 11673120
License Information
EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
History
Published online: 1 September 2001
Authors
Metrics & Citations
Metrics
Citations
Download citation
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click DOWNLOAD.
Cited by
- Paula Santos1 U, Algranti2 E, Mello De Capitani3 E, Faibischew Prado4 G, Scalia Carneiro5 A, Sousa Rodrigues6 S, Benedito Pires de Freitas1,7 J, Caruso Chate8,9 R, Futoshi Mizutani1 R, Albuquerque de Castro10 H, Abdo Arbex11 M, Canto Ribeiro12 P, Nunes Tietboehl Filho13 C, Cruz de Oliveira Castellano6 M, Ward Leite1 G, Corrêa de Almeida14 G, Occupational Diseases C, Brazilian Thoracic Society recommendations for the diagnosis and monitoring of asbestos-exposed individuals, Jornal Brasileiro de Pneumologia, 10.36416/1806-3756/e20240156, (e20240156), (2024).
- Ogun H, Kansu A, Kansu Z, Bayram M, Use of Geological Maps in Detecting Asbestos-Related Diseases; A New Region in Anatolia, Journal of Occupational & Environmental Medicine, 10.1097/JOM.0000000000003169, 66, 9, (e407-e412), (2024).
- “Tony” Havics A, Bernstein D, Serpentine and Amphibole Asbestos [A Subset of Elongated Mineral Particles (EMPs)], Patty's Toxicology, 10.1002/0471125474.tox012.pub3, (1-59), (2024).
- Ramos-Bonilla J, Giraldo M, Marsili D, Pasetto R, Terracini B, Mazzeo A, Magnani C, Comba P, Lysaniuk B, Cely-García M, Ascoli V, An Approach to Overcome the Limitations of Surveillance of Asbestos Related Diseases in Low- and Middle-Income Countries: What We Learned from the Sibaté Study in Colombia, Annals of Global Health, 10.5334/aogh.4166, 89, 1, (2023).
- Fazzo L, Minelli G, De Santis M, Ceccarelli E, Iavarone I, Zona A, The Epidemiological Surveillance of Mesothelioma Mortality in Italy as a Tool for the Prevention of Asbestos Exposure, International Journal of Environmental Research and Public Health, 10.3390/ijerph20115957, 20, 11, (5957), (2023).
- Magnani C, Mensi C, Binazzi A, Marsili D, Grosso F, Ramos-Bonilla J, Ferrante D, Migliore E, Mirabelli D, Terracini B, Consonni D, Degiovanni D, Lia M, Cely-García M, Giraldo M, Lysaniuk B, Comba P, Marinaccio A, The Italian Experience in the Development of Mesothelioma Registries: A Pathway for Other Countries to Address the Negative Legacy of Asbestos, International Journal of Environmental Research and Public Health, 10.3390/ijerph20020936, 20, 2, (936), (2023).
- Marinaccio A, Di Marzio D, Mensi C, Consonni D, Gioscia C, Migliore E, Genova C, Rossetto Giaccherino R, Eccher S, Murano S, Comiati V, Casotto V, Negro C, Mangone L, Miligi L, Piro S, Angelini A, Grappasonni I, Madeo G, Cozzi I, Ancona L, Staniscia T, Carrozza F, Cavone D, Vimercati L, Labianca M, Tallarigo F, Cascone G, Melis M, Bonafede M, Scarselli A, Binazzi A, Incidence of mesothelioma in young people and causal exposure to asbestos in the Italian national mesothelioma registry (ReNaM), Occupational and Environmental Medicine, 10.1136/oemed-2023-108983, 80, 11, (603-609), (2023).
- Kitamura Y, Zha L, Liu R, Shima M, Nakaya T, Kurumatani N, Kumagai S, Goji J, Sobue T, Association of mesothelioma deaths with neighborhood asbestos exposure due to a large‐scale asbestos‐cement plant, Cancer Science, 10.1111/cas.15802, 114, 7, (2973-2985), (2023).
- Bruno M, Cannizzaro A, Olori A, Tombolini F, Angelosanto F, Sinopoli F, Bruni B, Casalinuovo F, Campopiano A, Size characteristics of asbestiform fibers in lung tissue of animals that grazed in areas rich in ophiolitic outcrops in Central Calabria (Southern Italy), Science of The Total Environment, 10.1016/j.scitotenv.2022.159061, 856, (159061), (2023).
- Tarin D, Tarin D, Causes of Cancer and Mechanisms of Carcinogenesis, Understanding Cancer, 10.1007/978-3-030-97393-3_9, (229-279), (2023).
- See more