Assessment of lifestyle effects on the overall antioxidant capacity of healthy subjects.
Publication: Environmental Health Perspectives
Volume 110, Issue 5
Pages 479 - 486
Abstract
Oxidative damage is increasingly recognized as playing an important role in the pathogenesis of several diseases such as cancer and cardiovascular diseases. Using a biologic test based on whole blood resistance to free-radical aggression, we sought to evaluate lifestyle factors that may contribute to the normal variability of the overall antioxidant status. We assessed this global antiradical defense capacity in 88 men and 96 women in relation to information on lifestyle obtained by questionnaire. In our relatively young, healthy population, we found a weak negative relation between male sex or aging and the resistance to oxidant stress. Among the factors studied, nonsmoking, vitamin and/or mineral supplementation, and regular physical activity were closely associated with an increased overall antioxidant capacity. Conversely, the antioxidant potential was negatively related to tobacco smoking; psychologic stress; alcohol consumption; moderate vegetable, low fruit, and low fish consumption; and, to a lesser extent, high natural ultraviolet light exposure. Thus, we were able to determine "unhealthy" and "healthy" lifestyle patterns that truly contributed to the variation of individual antioxidant capacity. We conclude that lifestyle determinants of cancer and cardiovascular risks were associated with a decreased overall antioxidant status as dynamically measured by means of a biologic test. Thus, the evaluation of the total human resistance against free-radical aggression, taking into account nutritional habits, lifestyle, and environmental factors, may be useful in preventive medicine as a precocious diagnosis to identify healthy subjects who are at risk for free-radical-mediated diseases.
Formats available
You can view the full content in the following formats:
Information & Authors
Information
Published In
License Information
EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
History
Published online: 1 May 2002
Authors
Metrics & Citations
Metrics
Citations
Download citation
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click DOWNLOAD.
Cited by
- Sauvain J, Wild P, Charreau T, Jouannique V, Sakthithasan K, Debatisse A, Suárez G, Hopf N, Guseva Canu I, Are metals in exhaled breath condensate and urine associated with oxidative/nitrosative stress and metabolism-related biomarkers? Results from 303 randomly selected Parisian subway workers, Environment International, 10.1016/j.envint.2025.109325, 196, (109325), (2025).
- Ohashi K, Hayashida A, Nozawa A, Ito S, RNA sequencing analysis of early-stage atherosclerosis in vascular-on-a-chip and its application for comparing combustible cigarettes with heated tobacco products, Current Research in Toxicology, 10.1016/j.crtox.2024.100163, 6, (100163), (2024).
- Sheth M, Raina H, Singh A, Diverse stress and neurodegeneration; an overview, A Review on Diverse Neurological Disorders, 10.1016/B978-0-323-95735-9.00009-7, (465-477), (2024).
- Postnikov E, Wasiak M, Bartoszek M, Polak J, Zyubin A, Lavrova A, Chora̧żewski M, Accessing Properties of Molecular Compounds Involved in Cellular Metabolic Processes with Electron Paramagnetic Resonance, Raman Spectroscopy, and Differential Scanning Calorimetry, Molecules, 10.3390/molecules28176417, 28, 17, (6417), (2023).
- Jameel Q, Mohammed N, Ajeel M, Fabrication of Nutraceutical Beverage from Saffron (Crocus sativus L.) Extract and Studying Its Health Effects, International Journal of Food Science, 10.1155/2023/7130266, 2023, (1-10), (2023).
- Punjabi U, Goovaerts I, Peeters K, Van Mulders H, De Neubourg D, Sperm as a Carrier of Genome Instability in Relation to Paternal Lifestyle and Nutritional Conditions, Nutrients, 10.3390/nu14153155, 14, 15, (3155), (2022).
- Sołtysik B, Karolczak K, Watała C, Kostka T, The Association of Oxidative and Antioxidant Potential with Cardiometabolic Risk Profile in the Group of 60- to 65-Year-Old Seniors from Central Poland, Antioxidants, 10.3390/antiox11061065, 11, 6, (1065), (2022).
- Rasmussen J, Thompson P, Entringer S, Buss C, Wadhwa P, Fetal programming of human energy homeostasis brain networks: Issues and considerations, Obesity Reviews, 10.1111/obr.13392, 23, 3, (2021).
- Scariot P, Manchado-Gobatto F, Van Ginkel P, Prolla T, Gobatto C, Aerobic training associated with an active lifestyle exerts a protective effect against oxidative damage in hypothalamus and liver: The involvement of energy metabolism, Brain Research Bulletin, 10.1016/j.brainresbull.2021.07.018, 175, (116-129), (2021).
- Giroud S, Chery I, Arrivé M, Prost M, Zumsteg J, Heintz D, Evans A, Gauquelin-Koch G, Arnemo J, Swenson J, Lefai E, Bertile F, Simon C, Blanc S, Hibernating brown bears are protected against atherogenic dyslipidemia, Scientific Reports, 10.1038/s41598-021-98085-7, 11, 1, (2021).