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1 October 2015

POPs and Pubertal Timing: Evidence of Delayed Development

Publication: Environmental Health Perspectives
Volume 123, Issue 10
Page A266
Endocrine disruptors have been eyed as potential drivers of a steady trend toward earlier puberty among girls worldwide in recent decades, particularly with regard to breast development.1,2,3,4 However, when the authors of a study in this issue of EHP evaluated serum levels of three common classes of hormonally active persistent organic pollutants (POPs) in relation to the timing of pubertal onset in girls, they found, contrary to initial hypotheses, that higher exposures were associated with later puberty, not earlier.5
A small but growing body of literature suggests a complicated relationship between contaminants and pubertal development; factors such as stress, diet, and exercise also play an important role, says lead author Gayle Windham, a research scientist at the California Department of Public Health. Both earlier and later puberty have implications for psychosocial development,6 while early onset increases the risk of a range of physical health outcomes associated with prolonged exposure to estrogen,7 including breast cancer.8
Chemical exposures, along with stress, diet, and exercise, play a complicated role in the timing of pubertal development.
© Hero Images/Corbis
The current study involved a cohort of more than 600 ethnically diverse girls who were enrolled in the Puberty Study of the NIH-funded Breast Cancer and the Environment Research Program.9 The girls were enrolled between 2004 and 2007 when they were 6, 7, or 8 years old. Quartiles of exposure to polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs), and organochlorine pesticides were determined based on blood samples collected at enrollment. Pubertal development was subsequently monitored at up to seven annual clinic visits. Across the three classes of chemicals, breast development occurred a median of 6–11 months later among the most highly exposed girls versus those least exposed.5
While epidemiological evidence for the role of environmental exposures in pubertal timing remains mixed and inconclusive, researchers have reported an association between obesity and earlier puberty in girls.10,11 This may be due at least in part to the fact that fat cells produce estrogen.12 But the relationship is not one-directional, as more physically mature girls are also likely to have more body fat.13
When it comes to exposures to lipophilic chemicals such as those studied here, fat cells play yet another role by storing the chemicals and thus effectively diluting levels in the blood, says Brigham and Women’s Hospital physician and Harvard environmental epidemiologist Susan Korrick. “There’s always the possibility that BMI [body mass index] or relative body fat could confound or mediate the relationship between exposures and outcomes,” says Korrick, who was not involved in the study.
Indeed, when adjusting for BMI, the authors of the current study found that many of the associations between higher exposures and later pubertal onset were weaker. In the case of PCBs, the relationship was reversed altogether—among girls with higher BMI, puberty occurred earlier, not later, with higher exposure.5
Recent studies on phthalates14 and phenols15 coauthored by Windham and also conducted within the Breast Cancer and the Environment Research Program found higher exposures were associated with both earlier and later pubertal development, depending on the chemical congener. “I don’t think there’s going to be one explanation for this phenomenon of earlier puberty, and there may still be other chemicals found associated,” Windham says.
In any case, the results of the new study don’t let the target compounds off the hook. “The chemicals are potentially affecting the endocrine system, related to delays in pubertal onset,” Windham says. “That might, in turn, influence pregnancy or other reproductive outcomes in the future. If it’s messing with the endocrine system in some way, we’re going to be concerned.”

References

1.
Cesario SK, Hughes LA Precocious puberty: a comprehensive review of literature. J Obstet Gynecol Neonatal Nurs 36(3):263-274 2007.; https://doi.org/10.1111/j.1552-6909.2007.00145.x.
2.
Euling SY et al. Examination of US puberty-timing data from 1940 to 1994 for secular trends: panel findings. Pediatrics 121(suppl 3):S172-S191 2008.; https://doi.org/10.1542/peds.2007-1813D https://www.ncbi.nlm.nih.gov/pubmed/18245511.
3.
Aksglaede L et al. Recent decline in age at breast development: the Copenhagen Puberty Study. Pediatrics 123(5):e932-e939 2009.; https://doi.org/10.1542/peds.2008-2491 https://www.ncbi.nlm.nih.gov/pubmed/19403485.
4.
Maron DF. Early puberty: causes and effects. Sci Am 312(5):28,30 (2015). Available: http://www.scientificamerican.com/article/early-puberty-causes-and-effects/ [accessed 9 September 2015].
5.
Windham GC et al. Brominated flame retardants and other persistent organohalogenated compounds in relation to timing of puberty in a longitudinal study of girls. Environ Health Perspect 123(10):1046-1052 2015.; https://doi.org/10.1289/ehp.1408778 https://www.ncbi.nlm.nih.gov/pubmed/25956003.
6.
Mensah FK et al. Early puberty and childhood social and behavioral adjustment. J Adolesc Health 53(1):118-124 2013.; https://doi.org/10.1016/j.jadohealth.2012.12.018 https://www.ncbi.nlm.nih.gov/pubmed/23558038.
7.
Golub MS et al. Public health implications of altered puberty timing. Pediatrics 121(suppl 3):S218-S230 2008.; https://doi.org/10.1542/peds.2007-1813G https://www.ncbi.nlm.nih.gov/pubmed/18245514.
8.
Bernstein L Epidemiology of endocrine-related risk factors for breast cancer. J Mammary Gland Biol Neoplasia 7(1):3-15 2002.; https://doi.org/10.1023/A:1015714305420 https://www.ncbi.nlm.nih.gov/pubmed/12160084.
9.
BCERP. Puberty Study [website]. Research Triangle Park, NC and Bethesda, MD:National Institute of Environmental Health Sciences and National Institute of Cancer, National Institutes of Health (2015). Available: http://www.bcerc.org/granteesPS.htm [accessed 9 September 2015].
10.
Kaplowitz PB et al. Earlier onset of puberty in girls: relation to increased body mass index and race. Pediatrics 108(2):347-353 2001.; https://doi.org/10.1542/peds.108.2.347 https://www.ncbi.nlm.nih.gov/pubmed/11483799.
11.
Zhai L et al. Association of obesity with onset of puberty and sex hormones in Chinese girls: a 4-year longitudinal study. PLoS ONE 10(8):e0134656 2015.; https://doi.org/10.1371/journal.pone.0134656 https://www.ncbi.nlm.nih.gov/pubmed/26247479.
12.
Cleary MP, Grossman ME Obesity and breast cancer: the estrogen connection. Endocrinology 150(6):2537-2542 2009.; https://doi.org/10.1210/en.2009-0070 https://www.ncbi.nlm.nih.gov/pubmed/19372199.
13.
Burt Solozano CM, McCartney CR Obesity and the pubertal transition in girls and boys. Reproduction 140(3):399-410 2010.; https://doi.org/10.1530/REP-10-0119 https://www.ncbi.nlm.nih.gov/pubmed/20802107.
14.
Wolff MS et al. Phthalate exposure and pubertal development in a longitudinal study of US girls. Hum Reprod 29(7):1558-1566 2014.; https://doi.org/10.1093/humrep/deu081 https://www.ncbi.nlm.nih.gov/pubmed/24781428.
15.
Wolff MS et al. Environmental phenols and pubertal development in girls. Environ Int 84:174-180 2015.; https://doi.org/10.1016/j.envint.2015.08.008 https://www.ncbi.nlm.nih.gov/pubmed/26335517.

Information & Authors

Information

Published In

Environmental Health Perspectives
Volume 123Issue 10October 2015
Pages: A266
PubMed: 26421753

History

Published online: 1 October 2015

Authors

Affiliations

Nate Seltenrich
Nate Seltenrich covers science and the environment from Petaluma, CA. His work has appeared in High Country News, Sierra, Yale Environment 360, Earth Island Journal, and other regional and national publications.

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