Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.
Publication: Environmental Health Perspectives
Volume 111, Issue 16
Pages 1892 - 1901
Abstract
Perfluorooctanesulfonyl fluoride-based products have included surfactants, paper and packaging treatments, and surface protectants (e.g., for carpet, upholstery, textile). Depending on the specific functional derivatization or degree of polymerization, such products may degrade or metabolize, to an undetermined degree, to perfluorooctanesulfonate (PFOS), a stable and persistent end product that has the potential to bioaccumulate. In this investigation, a total of 645 adult donor serum samples from six American Red Cross blood collection centers were analyzed for PFOS and six other fluorochemicals using HPLC-electrospray tandem mass spectrometry. PFOS concentrations ranged from the lower limit of quantitation of 4.1 ppb to 1656.0 ppb with a geometric mean of 34.9 ppb [95% confidence interval (CI), 33.3-36.5]. The geometric mean was higher among males (37.8 ppb; 95% CI, 35.5-40.3) than among females (31.3 ppb; 95% CI, 30.0-34.3). No substantial difference was observed with age. The estimate of the 95% tolerance limit of PFOS was 88.5 ppb (upper limit of 95% CI, 100.0 ppb). The measures of central tendency for the other fluorochemicals (N-ethyl perfluorooctanesulfonamidoacetate, N-methyl perfluorooctanesulfonamidoacetate, perfluorooctanesulfonamidoacetate, perfluorooctanesulfonamide, perfluorooctanoate, and perfluorohexanesulfonate) were approximately an order of magnitude lower than PFOS. Because serum PFOS concentrations correlate with cumulative human exposure, this information can be useful for risk characterization.
Formats available
You can view the full content in the following formats:
Information & Authors
Information
Published In
Environmental Health Perspectives
Volume 111 • Issue 16 • December 2003
Pages: 1892 - 1901
PubMed: 14644663
License Information
EHP is an open-access journal published with support from the National Institute of Environmental Health Sciences, National Institutes of Health. All content is public domain unless otherwise noted.
History
Published online: 1 December 2003
Authors
Metrics & Citations
Metrics
Citations
Download citation
If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click DOWNLOAD.
Cited by
- Ludyn А, Reutskyy V, Reutskyy V, Perfluorinated sulfamides in the technology of complex utilization of cyclohexane oxidation products, Voprosy Khimii i Khimicheskoi Tekhnologii, 10.32434/0321-4095-2024-155-4-107-115, 4, (107-115), (2024).
- Ram H, DePompa C, Westmoreland P, Thermochemistry of Gas-Phase Thermal Oxidation of C 2 to C 8 Perfluorinated Sulfonic Acids with Extrapolation to C 16 , The Journal of Physical Chemistry A, 10.1021/acs.jpca.4c01208, 128, 17, (3387-3395), (2024).
- Ram H, Sadej T, Murphy C, Mallo T, Westmoreland P, Thermochemistry of Species in Gas-Phase Thermal Oxidation of C 2 to C 8 Perfluorinated Carboxylic Acids , The Journal of Physical Chemistry A, 10.1021/acs.jpca.3c06937, 128, 7, (1313-1326), (2024).
- Antonopoulou M, Spyrou A, Tzamaria A, Efthimiou I, Triantafyllidis V, Current state of knowledge of environmental occurrence, toxic effects, and advanced treatment of PFOS and PFOA, Science of The Total Environment, 10.1016/j.scitotenv.2023.169332, 913, (169332), (2024).
- Vaccari L, Ranzi A, Canova C, Ghermandi G, Giannini S, Pitter G, Russo F, Stefanelli J, Teggi S, Vantini A, Jeddi M, Fletcher T, Colacci A, Reliability of toxicokinetic modelling for PFAS exposure assessment in contaminated water in northern Italy, Heliyon, 10.1016/j.heliyon.2024.e35288, 10, 15, (e35288), (2024).
- Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y, Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN, Environmental Pollution, 10.1016/j.envpol.2024.123333, 344, (123333), (2024).
- Partington J, Marchiandi J, Szabo D, Gooley A, Kouremenos K, Smith F, Clarke B, Validating blood microsampling for per- and polyfluoroalkyl substances quantification in whole blood, Journal of Chromatography A, 10.1016/j.chroma.2023.464522, 1713, (464522), (2024).
- Nolen R, Prouse A, Russell M, Bloodgood J, Díaz Clark C, Carmichael R, Petersen L, Kaiser K, Hala D, Quigg A, Evaluation of fatty acids and carnitine as biomarkers of PFOS exposure in biota (fish and dolphin) from Galveston Bay and the northwestern Gulf of Mexico, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 10.1016/j.cbpc.2023.109817, 276, (109817), (2024).
- Reutskyy V, Ludyn А, Рerfluorinated sulfamides in the oxidation process of cyclohexane, Chemistry, Technology and Application of Substances, 10.23939/ctas2023.01.060, 6, 1, (60-68), (2023).
- Jones R, Madrigal J, Troisi R, Surcel H, Öhman H, Kivelä J, Kiviranta H, Rantakokko P, Koponen J, Medgyesi D, McGlynn K, Sampson J, Albert P, Ward M, Maternal serum concentrations of per- and polyfluoroalkyl substances and childhood acute lymphoblastic leukemia, JNCI: Journal of the National Cancer Institute, 10.1093/jnci/djad261, 116, 5, (728-736), (2023).
- See more