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Research Article
1 March 2004

Toward the effective surveillance of hypospadias.

Publication: Environmental Health Perspectives
Volume 112, Issue 3
Pages 398 - 402

Abstract

Concern about apparent increases in the prevalence of hypospadias--a congenital male reproductive-tract abnormality--in the 1960s to 1980s and the possible connection to increasing exposures to endocrine-disrupting chemicals have underlined the importance of effective surveillance of hypospadias prevalence in the population. We report here the prevalence of hypospadias from 1980 to 1999 in 20 regions of Europe with EUROCAT (European Surveillance of Congenital Anomalies) population-based congenital anomaly registers, 14 of which implemented a guideline to exclude glanular hypospadias. We also report data from the England and Wales National Congenital Anomaly System (NCAS). Our results do not suggest a continuation of rising trends of hypospadias prevalence in Europe. However, a survey of the registers and a special validation study conducted for the years 1994-1996 in nine EUROCAT registers as well as NCAS identified a clear need for a change in the guidelines for registration of hypospadias. We recommend that all hypospadias be included in surveillance, but that information from surgeons be obtained to verify location of the meatus, and whether surgery was performed, in order to interpret trends. Investing resources in repeated special surveys may be more cost-effective than continuous population surveillance. We conclude that it is doubtful whether we have had the systems in place worldwide for the effective surveillance of hypospadias in relation to exposure to potential endocrine-disrupting chemicals.

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Information

Published In

Environmental Health Perspectives
Volume 112Issue 3March 2004
Pages: 398 - 402
PubMed: 14998760

History

Published online: 1 March 2004

Authors

Affiliations

Helen Dolk
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Martine Vrijheid
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
John E S Scott
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Marie-Claude Addor
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Bev Botting
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Catherine de Vigan
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Hermien de Walle
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Ester Garne
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Maria Loane
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Anna Pierini
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Sixto Garcia-Minaur
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Nigel Physick
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Romano Tenconi
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Awi Wiesel
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
Elisa Calzolari
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]
David Stone
EUROCAT Central Registry, University of Ulster, Room 15E12, Newtownabbey, County Antrim, Northern Ireland BT37 0QB, UK. [email protected]

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Cited by

  • The prevalence of hypospadias in newborn males in Hangzhou, China from 2011 to 2020: A cross-sectional population-based study, Journal of Pediatric Urology, 10.1016/j.jpurol.2023.06.009, (2023).
  • Neural network non-linear modeling to predict hypospadias genotype–phenotype correlation, Journal of Pediatric Urology, 10.1016/j.jpurol.2023.01.005, 19, 3, (288.e1-288.e11), (2023).
  • Epidemiology of Hypospadias, Hypospadias Surgery, 10.1007/978-3-030-94248-9_10, (249-269), (2022).
  • Endocrine-Disrupting Chemicals and Disorders of Penile Development in Humans, Sexual Development, 10.1159/000517157, 15, 1-3, (213-228), (2021).
  • A Proteomics Signature of Mild Hypospadias: A Pilot Study, Frontiers in Pediatrics, 10.3389/fped.2020.586287, 8, (2020).
  • Risk of congenital anomalies near municipal waste incinerators in England and Scotland: Retrospective population-based cohort study, Environment International, 10.1016/j.envint.2019.05.039, 134, (104845), (2020).
  • The article contains the analysis of the literature devoted to the correction of hypospadias in children. Parallels are drawn between classical works and modern trends in the treatment of this malformation. New surgical techniques (with reference to the history of their appearance) and developments are described. There is a discussion about the use of single and staged surgical interventions in the proximal hypospadias, the analysis of literary data about the complications, results of operations. New classification parameters of hypospadias, methods of assessing the severity of the defect before surgery, functional and cosmetic results after surgery are described. Attention is paid to such direction as standardization of approaches to surgical treatment of hypospadias, unification of methods of urethroplasty and correction of penile curvature. The data of clinical studies on the use of various operational techniques are presented., Medical Almanac, 10.21145/2499-9954-2019-5-82-86, 5-6, (82-86), (2019).
  • Hypospadias Prevalence and Trends in International Birth Defect Surveillance Systems, 1980–2010, European Urology, 10.1016/j.eururo.2019.06.027, 76, 4, (482-490), (2019).
  • Cryptorchidism and Hypospadias, Health Impacts of Developmental Exposure to Environmental Chemicals, 10.1007/978-981-15-0520-1_4, (69-99), (2019).
  • Molecular genetics of hypospadias and cryptorchidism recent developments, Clinical Genetics, 10.1111/cge.13432, 95, 1, (122-131), (2018).

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