Research ArticleOpen Access
In vitro versus in vivo metabolic activation of mutagens.
- Cited ByHanig J and Osterberg R (2006) Drug Safety Toxicology Biological Concepts and Techniques in Toxicology, 10.1201/b14139-15, (249-271), Online publication date: 6-Mar-2006.Myers M, Dickens C and Schook L (1987) Alteration of macrophage anti-tumor activity and transferrin receptor expression by exposure to dimethylnitrosamine in vivo, Immunopharmacology, 10.1016/0162-3109(87)90058-0, 13:3, (195-205), Online publication date: 1-Jun-1987.Frezza D, Smith B and Zeiger E (1983) The intrasanguineous host mediated assay procedure using Saccharomyces cerevisiae: Comparison with two other metabolic activation systems, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(83)90117-3, 108:1-3, (161-168), Online publication date: 1-Mar-1983.Mayer V (1982) Genetic effects of naphthylamines, Mutation Research/Reviews in Genetic Toxicology, 10.1016/0165-1110(82)90051-3, 99:3, (349-369), Online publication date: 1-Nov-1982.Gupta K, Ulsamer A and Preuss P (1982) Formaldehyde in indoor air: Sources and toxicity, Environment International, 10.1016/0160-4120(82)90049-6, 8:1-6, (349-358), Online publication date: 1-Jan-1982.Müller D, Nelles J, Deparade E and Arni P (1980) The activity of S9-liver fractions from seven species in the Salmonella/mammalian-microsome mutagenicity test, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(80)90019-6, 70:3, (279-300), Online publication date: 1-May-1980.(1980) Genetic toxicology, Food and Cosmetics Toxicology, 10.1016/S0015-6264(80)80031-9, 18:6, (683-709), Online publication date: 1-Jan-1980.Solt A and Neale S (1980) Natulan, a bacterial mutagen requiring complex mammalian metabolic activation, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(80)90156-6, 70:2, (167-171), Online publication date: 1-Apr-1980.(1979) Chapter 17 Nitrosamines Potential Industrial Carcinogens and Mutagens, 10.1016/S0166-1116(08)71328-1, (331-355), .Edwards G, Whong W and Speciner N (1979) Intrahepatic mutagenesis assay: A sensitive method for detecting N-nitrosomorpholine and in vivo nitrosation of morpholine, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(79)90111-0, 64:6, (415-423), Online publication date: 1-Dec-1979.Frezza D, Zeiger E and Gupta B (1979) The intrasanguineous host-mediated assay procedure distribution and retention of yeast in the mouse, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(79)90122-5, 64:5, (295-305), Online publication date: 1-Oct-1979.Hsie A, Machanoff R, Couch D and Michael Holland J (1978) Mutagenicity of dimethylnitrosamine and ethyl methanesulfonate as determined by the host-mediated CHO/HGPRT assay, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(78)90010-6, 51:1, (77-84), Online publication date: 1-Jul-1978.(1978) Chapter 6 Genetic toxicology, Food and Cosmetics Toxicology, 10.1016/0015-6264(78)90010-X, 16, (35-63), Online publication date: 1-Dec-1978.Olajos E, Maverakis N and Cornish H (1978) Mutagenicity of alkyl-(ω-hydroxyalkyl) nitrosamines related to dibutylnitrosamine, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(78)90188-4, 56:3, (219-223), Online publication date: 1-Jan-1978.Olajos E and Coulston F (1978) Comparative toxicology of N-nitroso compounds and their carcinogenic potential to man, Ecotoxicology and Environmental Safety, 10.1016/S0147-6513(78)80008-6, 2:3-4, (317-367), Online publication date: 1-Dec-1978.Ficsor G, Bordás S, Wade S, Muthiani E, Wertz G and Zimmer D (1977) Mammalian host- and fluid-mediated mutagenicity assays of captan and streptozotocin in Salmonella typhimurium, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(77)90185-3, 48:1, (1-15), Online publication date: 1-Jan-1977.Arni P, Mantel T, Deparade E and Müller D (1977) Intrasanguine host-mediated assay with Salmonella typhimurium, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(77)90140-3, 45:3, (291-307), Online publication date: 1-Dec-1977.Olajos E (1977) Biological interactions of N-nitroso compounds: A review, Ecotoxicology and Environmental Safety, 10.1016/0147-6513(77)90034-3, 1:2, (175-196), Online publication date: 1-Sep-1977.Hauser R and Matter B (1977) Localization of E. coli K-12 in livers of mice used for an intrasanguineous host-mediated assay, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(77)90109-1, 46:1, (45-48), Online publication date: 1-Feb-1977.Bochkov N, Sram R, Kuleshov N and Zhurkov V (1976) System for the evaluation of the risk from chemical mutagens for man: Basic principles and practical recommendations, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(76)90190-4, 38:3, (191-201), Online publication date: 1-Jun-1976.Montesano R and Bartsch H (1976) Mutagenic and carcinogenic N-nitroso compounds: Possible environmental hazards, Mutation Research/Reviews in Genetic Toxicology, 10.1016/0165-1110(76)90001-4, 32:3-4, (179-227), Online publication date: 1-Jan-1976.Matter B (1976) Problems of testing drugs for potential mutagenicity, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(76)90149-7, 38:4, (243-258), Online publication date: 1-Aug-1976.Friedman M, Sanders V and Woods S (1976) Suppression of dimethylnitrosamine metabolism and toxicity by nitrososarcosine and other nitrosamines, Toxicology and Applied Pharmacology, 10.1016/0041-008X(76)90017-X, 36:2, (395-401), Online publication date: 1-May-1976.Friedman M and Couch D (1976) Suppression of hepatic DMN demethylase activity by nitrososarcosine and other nitrosamines, Biochemical Pharmacology, 10.1016/0006-2952(76)90261-6, 25:24, (2709-2712), Online publication date: 1-Dec-1976.Mohn G, Ellenberger J, McGregor D and Merker H (1975) Mutations in plants, microorganisms and in host-mediated assay systems, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/0027-5107(75)90143-8, 29:2, (221-233), Online publication date: 1-Aug-1975.Frantz C and Malling H (1975) The quantitative microsomal mutagenesis assay method, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(75)90047-3, 31:6, (365-380), Online publication date: 1-Dec-1975.Bartsch H, Malaveille C and Montesano R (1975) Differential effect of phenobarbitone, pregnenolone-16α-carbonitrile and aminoacetonitrile on dialkyinitrosamine metabolism and mutagenicity in vitro, Chemico-Biological Interactions, 10.1016/0009-2797(75)90059-9, 10:5, (377-382), Online publication date: 1-May-1975.Ong T and Malling H (1975) Microsomal activation of dimethylnitrosamine to metabolites mutagenic in Neurospora crassa, Mutation Research/Environmental Mutagenesis and Related Subjects, 10.1016/0165-1161(75)90090-4, 31:3, (195-196), Online publication date: 1-Jun-1975.Shahin M and de Serres F (1974) The effect of pH on hycanthone methanesulfonate-induced inactivation and mitotic recombination in saccharomyces, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/S0027-5107(74)80004-7, 26:5, (377-384), Online publication date: 1-Oct-1974.Malling H (1974) Mutagenic activation or dimethylnitrosamine and diethylnitrosamine in the host-mediated assay and the microsomal system, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 10.1016/S0027-5107(74)80047-3, 26:6, (465-472), Online publication date: 1-Dec-1974.
Publication History
- Originally published1 December 1973
- Published in print1 December 1973
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