Open access
Research Article
1 February 1979

Metabolic model for cadmium in man.

Publication: Environmental Health Perspectives
Volume 28
Pages 211 - 217


A metabolic model for cadmium has been formulated in terms of a flow scheme for cadmium among eight body compartments. The mathematical description of the flow of cadmium between compartments consits of a number of differential equations, and the accumulation of cadmium may thus be calculated. Coeffcients for the flow of cadmium were estimated from empirical data both from animals and man. The modelling serves two main purposes: it provides a means of using present knowledge about metabolism in order to calculate expected accumulation in critical organs and other tissues and body fluids at certain intake levels and it makes it possible to define deficiencies in our present knowledge about metabolism. Data recently collected, partly as a result of considerations related to the model, have confirmed the assumptions of a very long biological half-time in other tissues and the small excretion of cadmium via bile.

Formats available

You can view the full content in the following formats:

Information & Authors


Published In

Environmental Health Perspectives
Volume 28February 1979
Pages: 211 - 217
PubMed: 488035


Published online: 1 February 1979



Metrics & Citations


About Article Metrics


Download citation

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click DOWNLOAD.

Cited by

  • Metallothionein and Cadmium Toxicology—Historical Review and Commentary, Biomolecules, 10.3390/biom12030360, 12, 3, (360), (2022).
  • Toxicology of metals: Overview, definitions, concepts, and trends, Handbook on the Toxicology of Metals, 10.1016/B978-0-12-823292-7.00029-2, (1-14), (2022).
  • Exposure, dose, and toxicokinetics of metals, Handbook on the Toxicology of Metals, 10.1016/B978-0-12-823292-7.00025-5, (55-86), (2022).
  • Cadmium, Handbook on the Toxicology of Metals, 10.1016/B978-0-12-822946-0.00006-4, (141-196), (2022).
  • Levels of heavy metal cadmium in rice (Oryza sativa L.) produced in Taiwan and probabilistic risk assessment for the Taiwanese population, Environmental Science and Pollution Research, 10.1007/s11356-020-11902-w, 28, 22, (28381-28390), (2021).
  • Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling, Toxicology in Vitro, 10.1016/j.tiv.2019.104752, 63, (104752), (2020).
  • Risks of consuming cadmium-contaminated shellfish under seawater acidification scenario: Estimates of PBPK and benchmark dose, Ecotoxicology and Environmental Safety, 10.1016/j.ecoenv.2020.110763, 201, (110763), (2020).
  • Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway, International Journal of Environmental Research and Public Health, 10.3390/ijerph17010138, 17, 1, (138), (2019).
  • Augmentation of cadmium-induced oxidative cytotoxicity by pioglitazone in renal tubular epithelial cells, Toxicology and Industrial Health, 10.1177/0748233719869548, 35, 8, (530-536), (2019).
  • Chemical imaging and assessment of cadmium distribution in the human body, Metallomics, 10.1039/C9MT00178F, 11, 12, (2010-2019), (2019).

View Options

View options


View PDF

Get Access

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.







Copy the content Link

Share on social media