Skip to main content
Open access
Research Article
1 June 1990

Mortality of a cohort of workers in the styrene-butadiene polymer manufacturing industry (1943-1982).

Publication: Environmental Health Perspectives
Volume 86
Pages 107 - 117


A cohort of 12,110 male workers employed 1 or more years in eight styrene-butadiene polymer (SBR) manufacturing plants in the United States and Canada has been followed for mortality over a 40-year period, 1943 to 1982. The all-cause mortality of these workers was low [standardized mortality ratio (SMR) = 0.81] compared to that of the general population. However, some specific sites of cancers had SMRs that exceeded 1.00. These sites were then examined by major work divisions. The sites of interest included leukemia and non-Hodgkin's lymphoma in whites. The SMRs for cancers of the digestive tract were higher than expected, especially esophageal cancer in whites and stomach cancer in blacks. The SMR for arteriosclerotic heart disease in black workers was significantly higher than would be expected based on general population rates. Employees were assigned to a work area based on job longest held. The SMRs for specific diseases differed by work area. Production workers showed increased SMRs for hematologic neoplasms and maintenance workers, for digestive cancers. A significant excess SMR for arteriosclerotic heart disease occurred only in black maintenance workers, although excess mortality from this disease occurred in blacks regardless of where they worked the longest. A significant excess SMR for rheumatic heart disease was associated with work in the combined, all-other work areas. For many causes of death, there were significant deficits in the SMRs.

Formats available

You can view the full content in the following formats:

Information & Authors


Published In

Environmental Health Perspectives
Volume 86June 1990
Pages: 107 - 117
PubMed: 2401250


Published online: 1 June 1990



G M Matanoski
Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.
C Santos-Burgoa
Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.
L Schwartz
Johns Hopkins School of Hygiene and Public Health, Baltimore, MD 21205.

Metrics & Citations


About Article Metrics


Download citation

If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click DOWNLOAD.

Cited by

  • Flexible Electrically Conductive Elastomers, Advanced Multifunctional Materials from Fibrous Structures, 10.1007/978-981-99-6002-6_1, (1-25), (2023).
  • Aliphatic Hydrocarbons, Patty's Toxicology, 10.1002/0471125474.tox049.pub3, (1-125), (2023).
  • 1,3-Butadiene: a ubiquitous environmental mutagen and its associations with diseases, Genes and Environment, 10.1186/s41021-021-00233-y, 44, 1, (2022).
  • 1,3-Butadiene, styrene and lymphohaematopoietic cancers among North American synthetic rubber polymer workers: exposure–response analyses, Occupational and Environmental Medicine, 10.1136/oemed-2020-107197, 78, 12, (859-868), (2021).
  • Exposure to volatile organic compounds – acrolein, 1,3-butadiene, and crotonaldehyde – is associated with vascular dysfunction, Environmental Research, 10.1016/j.envres.2021.110903, 196, (110903), (2021).
  • Acute and chronic vascular effects of inhaled crotonaldehyde in mice: Role of TRPA1, Toxicology and Applied Pharmacology, 10.1016/j.taap.2020.115120, 402, (115120), (2020).
  • Crotonaldehyde-induced vascular relaxation and toxicity: Role of endothelium and transient receptor potential ankyrin-1 (TRPA1), Toxicology and Applied Pharmacology, 10.1016/j.taap.2020.115012, 398, (115012), (2020).
  • Association between residential greenness and exposure to volatile organic compounds, Science of The Total Environment, 10.1016/j.scitotenv.2019.135435, 707, (135435), (2020).
  • The association between urinary levels of 1,3-butadiene metabolites, cardiovascular risk factors, microparticles, and oxidative stress products in adolescents and young adults, Journal of Hazardous Materials, 10.1016/j.jhazmat.2020.122745, 396, (122745), (2020).
  • 1,3-Butadiene metabolite 1,2,3,4 diepoxybutane induces DNA adducts and micronuclei but not t(9;22) translocations in human cells, Chemico-Biological Interactions, 10.1016/j.cbi.2019.108797, 312, (108797), (2019).

View Options

View options


View PDF

Get Access

Restore your content access

Enter your email address to restore your content access:

Note: This functionality works only for purchases done as a guest. If you already have an account, log in to access the content to which you are entitled.







Copy the content Link

Share on social media