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Research Article
1 June 1995

Xenoestrogens released from lacquer coatings in food cans.

Publication: Environmental Health Perspectives
Volume 103, Issue 6
Pages 608 - 612


We present data showing that some foods preserved in lacquer-coated cans and the liquid in them may acquire estrogenic activity. Hormonal activity was measured using the E-screen bioassay. The biological activity of vegetables packed in cans was a result of plastic monomers used in manufacturing the containers. The plastic monomer bisphenol-A, identified by mass spectrometry, was found as a contaminant not only in the liquid of the preserved vegetables but also in water autoclaved in the cans. The amount of bisphenol-A in the extracts accounted for all the hormonal activity measured. Although the presence of other xenoestrogens cannot be ruled out, it is apparent that all estrogenic activity in these cans was due to bisphenol-A leached from the lacquer coating. The use of plastic in food-packaging materials may require closer scrutiny to determine whether epoxy resins and polycarbonates contribute to human exposure to xenoestrogens.

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Information & Authors


Published In

Environmental Health Perspectives
Volume 103Issue 6June 1995
Pages: 608 - 612
PubMed: 7556016


Published online: 1 June 1995



J A Brotons
Laboratorio de Investigaciones Médicas, Universidad de Granada, Spain.
M F Olea-Serrano
Laboratorio de Investigaciones Médicas, Universidad de Granada, Spain.
M Villalobos
Laboratorio de Investigaciones Médicas, Universidad de Granada, Spain.
V Pedraza
Laboratorio de Investigaciones Médicas, Universidad de Granada, Spain.
N Olea
Laboratorio de Investigaciones Médicas, Universidad de Granada, Spain.

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