Open access
Research Article
1 April 1996

The Agricultural Health Study.

Publication: Environmental Health Perspectives
Volume 104, Issue 4
Pages 362 - 369

Abstract

The Agricultural Health Study, a large prospective cohort study has been initiated in North Carolina and Iowa. The objectives of this study are to: 1) identify and quantify cancer risks among men, women, whites, and minorities associated with direct exposure to pesticides and other agricultural agents; 2) evaluate noncancer health risks including neurotoxicity reproductive effects, immunologic effects, nonmalignant respiratory disease, kidney disease, and growth and development among children; 3) evaluate disease risks among spouses and children of farmers that may arise from direct contact with pesticides and agricultural chemicals used in the home lawns and gardens, and from indirect contact, such as spray drift, laundering work clothes, or contaminated food or water; 4) assess current and past occupational and nonoccupational agricultural exposures using periodic interviews and environmental and biologic monitoring; 5) study the relationship between agricultural exposures, biomarkers of exposure, biologic effect, and genetic susceptibility factors relevant to carcinogenesis; and 6) identify and quantify cancer and other disease risks associated with lifestyle factors such as diet, cooking practices, physical activity, smoking and alcohol consumption, and hair dye use. In the first year of a 3-year enrollment period, 26,235 people have been enrolled in the study, including 19,776 registered pesticide applicators and 6,459 spouses of registered farmer applicators. It is estimated that when the total cohort is assembled in 1997 it will include approximately 75,000 adult study subjects. Farmers, the largest group of registered pesticide applicators comprise 77% of the target population enrolled in the study. This experience compares favorably with enrollment rates of previous prospective studies.

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Information & Authors

Information

Published In

Environmental Health Perspectives
Volume 104Issue 4April 1996
Pages: 362 - 369
PubMed: 8732939

History

Published online: 1 April 1996

Authors

Affiliations

M C Alavanja
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
D P Sandler
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
S B McMaster
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
S H Zahm
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
C J McDonnell
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
C F Lynch
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
M Pennybacker
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
N Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
M Dosemeci
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
A E Bond
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
A Blair
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.

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Cited by

  • An Updated Evaluation of Atrazine-Cancer Incidence Associations among Pesticide Applicators in the Agricultural Health Study Cohort, Environmental Health Perspectives, 10.1289/EHP13684, 132, 2, (2024).
  • Ingested nitrate and nitrite and end-stage renal disease in licensed pesticide applicators and spouses in the Agricultural Health Study, Journal of Exposure Science & Environmental Epidemiology, 10.1038/s41370-023-00625-y, (2024).
  • Pesticide use and inflammatory bowel disease in licensed pesticide applicators and spouses in the Agricultural Health Study, Environmental Research, 10.1016/j.envres.2024.118464, 249, (118464), (2024).
  • Occupational farm work activities influence workers’ indoor home microbiome, Environmental Research, 10.1016/j.envres.2023.117819, 243, (117819), (2024).
  • Comprehensive evaluation of smoking exposures and their interactions on DNA methylation, eBioMedicine, 10.1016/j.ebiom.2023.104956, 100, (104956), (2024).
  • Metagenomics reveals novel microbial signatures of farm exposures in house dust, Frontiers in Microbiology, 10.3389/fmicb.2023.1202194, 14, (2023).
  • Glyphosate Use and Mosaic Loss of Chromosome Y among Male Farmers in the Agricultural Health Study, Environmental Health Perspectives, 10.1289/EHP12834, 131, 12, (2023).
  • Human exposure to pesticides and thyroid cancer: a worldwide systematic review of the literatures, Thyroid Research, 10.1186/s13044-023-00153-9, 16, 1, (2023).
  • Using a smartphone application to capture daily work activities: a longitudinal pilot study in a farming population, Annals of Work Exposures and Health, 10.1093/annweh/wxad034, 67, 7, (895-906), (2023).
  • Analysis of mitochondrial DNA copy number variation in Brazilian farmers occupationally exposed to pesticides, International Journal of Environmental Health Research, 10.1080/09603123.2023.2280147, (1-10), (2023).
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