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Research Article
1 March 1997

Maternal smoking during pregnancy and postnatal exposure to environmental tobacco smoke as predisposition factors to acute respiratory infections.

Publication: Environmental Health Perspectives
Volume 105, Issue 3
Pages 302 - 306

Abstract

This study compared susceptibility to respiratory morbidity in a cohort of 9-year-old children exposed congenitally and postnatally to environmental tobacco smoke (ETS) to susceptibility in a cohort of unexposed children. The epidemiologic study included 1129 children: 594 boys and 535 girls attending the second grade of grammar schools in Kraków, Poland. We found strong evidence that children exposed to ETS in their homes were more susceptible to acute respiratory tract illnesses than unexposed children. A dose-response relationship between degree of exposure [for lower ETS exposure, odds ratio (OR) = 1.32; for higher ETS exposure, OR = 1.74] supports a causal explanation for the association observed. The significant trend of increased risk of respiratory infections due to ETS level in nonatopic children whose mothers did not smoke cigarettes during pregnancy suggests a direct effect of ETS exposure on the child's respiratory health. ETS combined with allergy nearly tripled the risk of acute respiratory tract illness (OR = 3.39; 95% CI, 1.93-5.93), and maternal smoking during pregnancy had a modifying effect on the risk of respiratory illnesses due to ETS after accounting for atopy. The stronger effect of ETS in atopic children and in those whose mothers smoked during pregnancy may be result of biologic interaction of endogenous and environmental factors. The results of this study are of relevance to public health policy, as children with higher risk of respiratory infections may be more susceptible to environmental hazards later in adolescence or in adulthood. Respiratory infections also increase demands for medical interventions in terms of outpatient services and hospital administrations. In addition, respiratory illnesses cause missed school days, and caring for a sick child may lead to absenteeism from work.

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Published In

Environmental Health Perspectives
Volume 105Issue 3March 1997
Pages: 302 - 306
PubMed: 9171991

History

Published online: 1 March 1997

Authors

Affiliations

W Jedrychowski
Collegium Medicum, Jagiellonian University, Kraków, Poland.
E Flak
Collegium Medicum, Jagiellonian University, Kraków, Poland.

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Cited by

  • Why do some Children Get Sick with Recurrent Respiratory Infections?, Current Pediatric Reviews, 10.2174/1573396320666230912103056, 20, 3, (203-215), (2024).
  • Alarming Trend in Under-Five Indian Children’s Exposure to Indoor Tobacco Smoke, Cureus, 10.7759/cureus.37571, (2023).
  • Modeling the effects of cigarette smoke extract on influenza B virus infections in mice, Frontiers in Immunology, 10.3389/fimmu.2023.1083251, 14, (2023).
  • Investigating the role of relationship satisfaction and paternal psychological distress during pregnancy on offspring health in early life, BJPsych Open, 10.1192/bjo.2023.59, 9, 3, (2023).
  • Interactions of genetic variants and prenatal stress in relation to the risk for recurrent respiratory infections in children, Scientific Reports, 10.1038/s41598-021-87211-0, 11, 1, (2021).
  • Effects of parental smoking and indoor tobacco smoke exposure on respiratory outcomes in children, Scientific Reports, 10.1038/s41598-020-60700-4, 10, 1, (2020).
  • Passive smoking induces pediatric asthma by affecting the balance of Treg/Th17 cells, Pediatric Research, 10.1038/s41390-019-0276-0, 85, 4, (469-476), (2019).
  • Prenatal Maternal Psychological Distress and Offspring Risk for Recurrent Respiratory Infections, The Journal of Pediatrics, 10.1016/j.jpeds.2018.12.050, 208, (229-235.e1), (2019).
  • Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections, The Journal of Immunology, 10.4049/jimmunol.1701417, 200, 8, (2927-2940), (2018).
  • Passive smoking, sudden infant death syndrome (SIDS) and childhood infections, Human & Experimental Toxicology, 10.1191/096032799678839914, 18, 4, (202-205), (2016).

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