Skip to content

Environmental Health Perspectives

Facebook Page EHP Twitter Feed Open Access icon  

Science Selection May 2018 | Volume 126 | Issue 5

Environ Health Perspect; DOI:10.1289/EHP3435

Scratching the Surface: Exploring the Association between Prenatal Phthalate Exposure and Eczema in Boys

Charles W. Schmidt

PDF icon PDF Version (28.7 MB)

  • Published: 31 May 2018

    Note to readers with disabilities: EHP strives to ensure that all journal content is accessible to all readers. However, some figures and Supplemental Material published in EHP articles may not conform to 508 standards due to the complexity of the information being presented. If you need assistance accessing journal content, please contact ehponline@niehs.nih.gov. Our staff will work with you to assess and meet your accessibility needs within 3 working days.

Related EHP Article

Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother–Child Cohort Study

Munawar Hussain Soomro, Nour Baiz, Claire Philippat, Celine Vernet, Valerie Siroux, Cara Nichole Maesano, Shreosi Sanyal, Remy Slama, Carl-Gustaf Bornehag, and Isabella Annesi-Maesano



Phthalate plasticizers are so ubiquitous that nearly everyone comes in daily contact with them through plastics, personal care products, and countless other consumer and industrial products.1 Studies in laboratory animals and wildlife show that phthalates can cause a variety of reproductive and developmental problems in offspring, in part by disrupting normal hormonal functioning.2,3 The epidemiologic evidence is weaker by comparison, but some studies have reported associations with reproductive1 and neurodevelopmental4 outcomes, as well as with asthma and allergic conditions.5 A study in Environmental Health Perspectives now reports that prenatal exposure to phthalates may elevate the risk of eczema in boys.6

“The associations between phthalate measures during pregnancy and childhood eczema were quite strong,” says study coauthor Carl-Gustaf Bornehag, a professor in the Department of Health Sciences at Karlstad University, Sweden, and an adjunct professor at the Icahn School of Medicine at Mount Sinai in New York City.

Eczema is relatively common in children, with prevalence rates ranging from 3% to 37%, depending on geographic location.7,8 Many children recover as they grow older. Characterized by patches of dry, itchy skin that erupt into rashes when scratched, the causes of eczema remain unclear but likely depend on both genetic and environmental factors.9

Photograph of a baby's arm covered with eczema

According to the 2010 Global Burden of Disease survey, atopic eczema ranked highest among skin disorders in terms of disability-adjusted life years.10 The burden extends beyond the immediate physical symptoms; the pain and itching associated with eczema may cause difficulty sleeping or concentrating, poorer performance at school or work, depression or anxiety, and other adverse effects.11 Image: © Eaaw/Shutterstock.

For the present study, Bornehag and his colleagues relied on data from a prospective birth cohort called EDEN (Etude des Déterminants pré et post natals du développement de la santé de l’Enfant). The EDEN cohort includes only mother–son pairs—an advantage for conducting studies on potentially male-specific outcomes. Launched in 2003, the EDEN cohort enrolled 2,002 pregnant women from two cities in France. Researchers are now assessing how maternal health status and environmental exposures during pregnancy relate to the boys’ health as they get older.

The authors focused specifically on 604 boys born to mothers who supplied a single urine sample between weeks 24 and 28 of pregnancy. Urinary levels of a total of 11 metabolites from eight phthalates were assessed in relation to eczema incidence during the first five years of each boy’s life. The researchers also measured the levels of immunoglobulin E (IgE) antibodies in the children’s blood serum. High IgE levels are associated with an immunological condition known as atopy, which predisposes children to allergic diseases such as asthma, rhinitis, and atopic eczema.

The researchers classified eczema as early-onset if it occurred before 2 years of age or late-onset if it began at 2 years or older. They found statistically significant associations between both early- and late-onset eczema and the metabolites of two phthalates in particular: diisobutyl phthalate (DiBP) and diisononyl phthalate (DiNP). Moreover, the association between prenatal phthalate exposure and eczema was mainly found in boys with high IgE levels.

Joseph Braun, an assistant professor of public health and epidemiology at the Brown University School of Public Health, who was not involved in the study, says the findings “add to a small but growing body of literature showing that prenatal phthalate exposure may affect the risk of allergic diseases in children.” The study’s major strength, he says, is its large sample size.

However, Braun adds that associations between eczema and prenatal phthalate exposures might actually reflect effects of phthalate exposures during childhood. He explains that a mother’s exposures to phthalates during pregnancy (through contact with personal care products, vinyl flooring, furniture, electronics, toys, and other everyday items) may be similar to her exposures after her child is born—and similar to her child’s postnatal exposures if they share the same home. “So it is not clear if this study points to a unique window of heightened vulnerability during gestation or the effects of being exposed to phthalates during early childhood,” he says.

Barbara Demeneix, a professor of comparative physiology at the Natural History Museum in Paris, says the study’s exposure limitations work in the other direction as well, given that human embryos could be especially vulnerable to phthalates in early pregnancy, when organs are beginning to form. Ideally, prenatal exposures could be measured at multiple times during pregnancy, particularly during the first trimester. Demeneix was not involved in the new study.

Bornehag agrees on the need for first-trimester data and affirms that postnatal exposures may also play a role in eczema. He adds that phthalate levels might change over the course of pregnancy if a mother changes her lifestyle and that there may be sensitive time windows during early life for immunological development.

What Bornehag and his colleagues want to investigate now is whether prenatal phthalate exposures trigger an “atopic march,” an allergic progression that begins with eczema during early childhood and then advances into asthma and rhinitis later. “That’s one of the key questions,” Bornehag says. “And we have to work on getting more prenatal exposure data for girls as well.”


Charles W. Schmidt, MS, an award-winning science writer from Portland, Maine, writes for Scientific American, Science, various Nature publications, and many other magazines, research journals, and websites.

References

1. Meeker JD, Sathyanarayana S, Swan SH. 2009. Phthalates and other additives in plastics: human exposure and associated health outcomes. Philos Trans R Soc Lond B Biol Sci 364(1526):2097–2113, PMID: 19528058, 10.1098/rstb.2008.0268.

2. Abdel-Maksoud FM, Leasor KR, Butzen K, Braden TD, Akingbemi BT. 2015. Prenatal exposures of male rats to the environmental chemicals bisphenol A and di(2-ethylhexyl) phthalate impact the sexual differentiation process. Endocrinology 156(12):4672–4683, PMID: 26372177, 10.1210/en.2015-1077.

3. Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, et al. 2009. A critical analysis of the biological impacts of plasticizers on wildlife. Philos Trans R Soc Lond B Biol Sci 364(1526):2047–2062, PMID: 19528055, 10.1098/rstb.2008.0242.

4. Ejaredar M, Nyanza EC, Ten Eycke K, Dewey D. 2015. Phthalate exposure and childrens neurodevelopment: a systematic review. Environ Res 142:51–60, PMID: 26101203, 10.1016/j.envres.2015.06.014.

5. Robinson L, Miller R. 2015. The impact of bisphenol A and phthalates on allergy, asthma, and immune function: a review of latest findings. Curr Environ Health Rep 2(4):379–387, PMID: 26337065, 10.1007/s40572-015-0066-8.

6. Soomro MH, Baiz N, Philippat C, Vernet C, Siroux V, Nichole Maesano C, et al. 2018. Prenatal exposure to phthalates and the development of eczema phenotypes in male children: results from the EDEN Mother–Child Cohort Study. Environ Health Perspect 126(2):027002, PMID: 29398652, 10.1289/EHP1829.

7. Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK. 2006. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet 368(9537):733–743, PMID: 16935684, 10.1016/S0140-6736(06)69283-0.

8. Nutten S. 2015. Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab 66 (suppl1):8–16, PMID: 25925336, 10.1159/000370220.

9. Pyun BY. 2015. Natural history and risk factors of atopic dermatitis in children. Allergy Asthma Immunol Res 7(2):101–105, PMID: 25729616, 10.4168/aair.2015.7.2.101.

10. Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. 2012. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2197–2223, PMID: 23245608, 10.1016/S0140-6736(12)61689-4.

11. Silverberg JI. 2017. Public health burden and epidemiology of atopic dermatitis. Dermatol Clin 35(3):283–289, PMID: 28577797, 10.1016/j.det.2017.02.002.


WP-Backgrounds Lite by InoPlugs Web Design and Juwelier Schönmann 1010 Wien