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Correspondence Volume 125 | 2017

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Environ Health Perspect; DOI:10.1289/EHP852

Comment on “Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease”

Tara Ahmed,1 Heval Mohamed Kelli,2 and Pratik Sandesara2

1Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; 2Emory Clinical Cardiovascular Research Institute, Emory University, Atlanta, Georgia, USA

About This Article open

Citation: Ahmed T, Kelli HM, Sandesara P. 2017. Comment on “Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease.” Environ Health Perspect 125:A15; http://dx.doi.org/10.1289/EHP852

Address correspondence to H.M. Kelli, Emory Clinical Cardiovascular Research Institute, Emory University School of Medicine, 1462 Clifton Rd NE, Ste 513, Atlanta, GA 30329 USA. Telephone: 404-727-9281. E-mail: hkelli@emory.edu

The authors declare they have no actual or potential competing financial interests.

Final Publication: 1 January 2017

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Related EHP Articles

Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease

Gloria C. Chi, Anjum Hajat, Chloe E. Bird, Mark R. Cullen, Beth Ann Griffin, Kristin A. Miller, Regina A. Shih, Marcia L. Stefanick, Sverre Vedal, Eric A. Whitsel, and Joel D. Kaufman

Response to “Comment on ‘Individual and Neighborhood Socioeconomic Status and the Association between Air Pollution and Cardiovascular Disease’”

Gloria C. Chi, Anjum Hajat, Kristin A. Miller, Eric A. Whitsel, Beth Ann Griffin, Regina A. Shih, and Joel D. Kaufman

We read with great interest Chi et al.’s article examining the role of socioeconomic status (SES) in the air pollution–cardiovascular disease (CVD) relationship. We appreciate their consideration of multiple levels of SES in this relationship. The authors have paved the path to consider similar studies on other populations. However, we note that, given the composition of the study population, the findings of this report can be generalized only to a subset of the population who are female, white, postmenopausal, over 50 years old, and free of CVD at baseline. In order for the findings to apply to the general population, potential differences related to factors such as sex and race would need to be considered.

As CVD research has grown to include more female participants, significant sex differences have recently been found. Atypical presentation of CVD is more prevalent in women than in men (Canto et al. 2012; Ski et al. 2014). Moreover, the sex disparity in evidence-based treatment can lead to delayed intervention and adverse cardiovascular outcomes (Ski et al. 2014). In addition, the risk for cardiovascular complications in diabetics is higher in women than in men (Huxley et al. 2006; Maas and Appelman 2010). Since there are substantial sex differences in CVD, there may also be sex differences in the role of SES in the association between air pollution and CVD.

While the article provides relatively recent findings, its applicability to current populations is limited due to the data collection timeline. Participants were initially enrolled between 1993 and 1998. This enrollment period occurred before a crucial turning point in health care, specifically the 1999 release of the first woman-specific clinical recommendations by the American Heart Association (Lewis et al. 2009; Mosca et al. 2011; Ski et al. 2014). Since the release of the recommendations, there have been major improvements and changes in risk factor awareness, prevention, and treatment of CVD in women (Lewis et al. 2009; Mosca et al. 2011; Ski et al. 2014). Furthermore, in 2004 the American Heart Association published the first evidence-based guidelines for female CVD prevention, and the rate of death from CVD among women decreased by nearly half between 1997 and 2009 (Mosca et al. 2011). Therefore, if the same study were conducted today, we speculate that the findings might be different based on these more recent improvements in women’s CVD awareness, prevention, and treatment.

In addition to sex differences, notable differences in CVD have been associated with racial and ethnic differences. CVD, related risk factors, and mortality have occurred at a higher prevalence in black individuals than in white individuals (Feinstein et al. 2012; Ski et al. 2014). For example, the prevalence of CVD in black women is 47%, compared with 34% in white women (Mosca et al. 2011; Roger et al. 2011). In 2007 the rate of hypertension as a cause of death in black women was nearly double the rate in white women (Mosca et al. 2011; Roger et al. 2011). These differences emphasize the need to consider potential racial disparities, as well as sex disparities, when examining the role of SES in the air pollution–CVD relationship.

Finally, Chi et al. excluded 18,576 participants for having CVD at baseline. While their findings have implications for preventing CVD outcomes in individuals who initially lack CVD, it would also be informative to conduct a similar study in those who do have CVD at baseline. Such a study could yield insight into individuals’ susceptibility to progression of CVD, related hospitalizations or mortality, comorbidities, and overall health.


References

Canto JG, Rogers WJ, Goldberg RJ, Peterson ED, Wenger NK, Vaccarino V, et al. 2012. Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality. JAMA 307(8):813–822, doi: 10.1001/jama.2012.199.

Feinstein M, Ning H, Kang J, Bertoni A, Carnethon M, Lloyd-Jones DM. 2012. Racial differences in risks for first cardiovascular events and noncardiovascular death. The Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, and the Multi-Ethnic Study of Atherosclerosis. Circulation 126(1):50–59, doi: 10.1161/circoutcomes.108.824763.

Huxley R, Barzi F, Woodward M. 2006. Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ 332:73–78, doi: 10.1136/bmj.38678.389583.7C.

Lewis WR, Ellrodt AG, Peterson E, Hernandez AF, LaBresh KA, Cannon CP, et al. 2009. Trends in the use of evidence-based treatments for coronary artery disease among women and the elderly. Findings from the Get With the Guidelines quality-improvement program. Circ Cardiovasc Qual Outcomes 2(6):633–641, doi: 10.1161/circoutcomes.108.824763.

Maas AHEM, Appelman YEA. 2010. Gender differences in coronary heart disease. Neth Heart J 18(12):598–603, doi: 10.1007/s12471-010-0841-y.

Mosca L, Barrett-Connor E, Wenger NK. 2011. Sex/gender differences in cardiovascular disease prevention. What a difference a decade makes. Circulation 124(19):2145–2154, doi: 10.1161/circulationaha.110.968792.

Roger VL, Go AS, Lloyd-Jones DM, Adams RJ, Berry JD, Brown TM, et al. 2011. American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2011 update: a report from the American Heart Association. Circulation 123(4):e18–e209, doi: 10.1161/cir.0b013e3182009701.

Ski CF, King-Shier KM, Thompson DR. 2014. Gender, socioeconomic and ethnic/racial disparities in cardiovascular disease: a time for change. Int J Cardiol 170(3):255–257, doi: 10.1016/j.ijcard.2013.10.082.


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