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Environmental Health Perspectives

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March 2014 | Volume 122 | Issue 3


March 2014 coverFocus

A Question for Women’s Health: Chemicals in Feminine Hygiene Products and Personal Lubricants

Wendee Nicole | A70

Mucous membranes in the vagina and vulva rapidly absorb chemicals without metabolizing them. But until recently, scant research existed on how chemicals in feminine hygiene products and personal lubricants may affect women’s health. With new findings emerging in this largely overlooked research area, several researchers and interest groups are calling for more research to fill in the data gaps.

Image: © Alan Oliver/Alamy

Screenshot of the NTP Nonneoplastic Lesion AtlasSpheres of Influence

NTP Nonneoplastic Lesion Atlas: A New Tool for Toxicologic Pathology

Charles W. Schmidt | A76

For decades, pathologists have diagnosed nonneoplastic lesions and other tissue findings by matching what they see under the microscope with a picture in a textbook or journal. A new website hosted by the National Toxicology Program is bringing that process into the digital age and promises to significantly improve the ability of researchers to evaluate noncancer findings in animal studies.

Image: © Denys Prykhodov/Shutterstock

Science Selections

Chemical Contaminants in Drinking Water: Where Do We Go from Here?

Julia R. Barrett | A80

Also see Villanueva et al., p. 213

Hidden Blue Hazard? LED Lighting and Retinal Damage in Rats

Tim Lougheed | A81

Also see Shang et al., p. 269

Clues to Arsenic’s Toxicity: Microbiome Alterations in the Mouse Gut

Carol Potera | A82

Also see Lu et al., p. 284


Assessing Exposure and Health Consequences of Chemicals in Drinking Water: Current State of Knowledge and Research Needs

Cristina M. Villanueva, Manolis Kogevinas, Sylvaine Cordier, Michael R. Templeton, Roel Vermeulen, John R. Nuckols, Mark J. Nieuwenhuijsen, and Patrick Levallois | 213

Also see Science Selections, p. A80


Metagenomic Frameworks for Monitoring Antibiotic Resistance in Aquatic Environments

Jesse A. Port, Alison C. Cullen, James C. Wallace, Marissa N. Smith, and Elaine M. Faustman | 222

Cumulative Lead Exposure and Age at Menopause in the Nurses’ Health Study Cohort

Ki-Do Eum, Marc G. Weisskopf, Linda H. Nie, Howard Hu, and Susan A. Korrick | 229

Temporal Trends in Phthalate Exposures: Findings from the National Health and Nutrition Examination Survey, 2001–2010

Ami R. Zota, Antonia M. Calafat, and Tracey J. Woodruff | 235

Brachial Artery Responses to Ambient Pollution, Temperature, and Humidity in People with Type 2 Diabetes: A Repeated-Measures Study

Antonella Zanobetti, Heike Luttmann-Gibson, Edward S. Horton, Allison Cohen, Brent A. Coull, Barbara Hoffmann, Joel D. Schwartz, Murray A. Mittleman, Yongsheng Li, Peter H. Stone, Celine de Souza, Brooke Lamparello, Petros Koutrakis, and Diane R. Gold | 242

Associations between Extreme Precipitation and Gastrointestinal-Related Hospital Admissions in Chennai, India

Kathleen F. Bush, Marie S. O’Neill, Shi Li, Bhramar Mukherjee, Howard Hu, Santu Ghosh, and Kalpana Balakrishnan | 249

Chronic Arsenic Exposure and Angiogenesis in Human Bronchial Epithelial Cells via the ROS/miR-199a-5p/HIF-1α/COX-2 Pathway

Jun He, Min Wang, Yue Jiang, Qiudan Chen, Shaohua Xu, Qing Xu, Bing-Hua Jiang, and Ling-Zhi Liu | 255

Diethylstilbestrol (DES)-Stimulated Hormonal Toxicity Is Mediated by ERα Alteration of Target Gene Methylation Patterns and Epigenetic Modifiers (DNMT3A, MBD2, and HDAC2) in the Mouse Seminal Vesicle

Yin Li, Katherine J. Hamilton, Anne Y. Lai, Katherine A. Burns, Leping Li, Paul A. Wade, and Kenneth S. Korach | 262

White Light–Emitting Diodes (LEDs) at Domestic Lighting Levels and Retinal Injury in a Rat Model

Yu-Man Shang, Gen-Shuh Wang, David Sliney, Chang-Hao Yang, and Li-Ling Lee | 269

Also see Science Selections, p. A81

Impaired Lipid and Glucose Homeostasis in Hexabromocyclododecane-Exposed Mice Fed a High-Fat Diet

Rie Yanagisawa, Eiko Koike, Tin-Tin Win-Shwe, Megumi Yamamoto, and Hirohisa Takano | 277

Arsenic Exposure Perturbs the Gut Microbiome and Its Metabolic Profile in Mice: An Integrated Metagenomics and Metabolomics Analysis

Kun Lu, Ryan Phillip Abo, Katherine Ann Schlieper, Michelle E. Graffam, Stuart Levine, John S. Wishnok, James A. Swenberg, Steven R. Tannenbaum, and James G. Fox | 284

Also see Science Selections, p. A82

Children’s Health

Behavioral Sexual Dimorphism in School-Age Children and Early Developmental Exposure to Dioxins and PCBs: A Follow-Up Study of the Duisburg Cohort

Gerhard Winneke, Ulrich Ranft, Jürgen Wittsiepe, Monika Kasper-Sonnenberg, Peter Fürst, Ursula Krämer, Gabriele Seitner, and Michael Wilhelm | 292

Urinary Polycyclic Aromatic Hydrocarbons and Childhood Obesity: NHANES (2001–2006)

Franco Scinicariello and Melanie C. Buser | 299

Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene (p,p′-DDE) with Testosterone Levels in Adolescent Males

Lawrence M. Schell, Mia V. Gallo, Glenn D. Deane, Kyrie R. Nelder, Anthony P. DeCaprio, Agnes Jacobs, and the Akwesasne Task Force on the Environment | 304

Domain-Specific Effects of Prenatal Exposure to PCBs, Mercury, and Lead on Infant Cognition: Results from the Environmental Contaminants and Child Development Study in Nunavik

Olivier Boucher, Gina Muckle, Joseph L. Jacobson, R. Colin Carter, Melissa Kaplan-Estrin, Pierre Ayotte, Éric Dewailly, and Sandra W. Jacobson | 310

Traffic-Related Air Pollution and Congenital Anomalies in Barcelona

Anna Schembari, Mark J. Nieuwenhuijsen, Joaquin Salvador, Audrey de Nazelle, Marta Cirach, Payam Dadvand, Rob Beelen, Gerard Hoek, Xavier Basagaña, and Martine Vrijheid | 317



Instruments for Assessing Risk of Bias and Other Methodological Criteria of Animal Studies: Omission of Well-Established Methods

Nancy B. Beck, Richard A. Becker, Alan Boobis, Dean Fergusson, John R. Fowle III, Julie Goodman, Sebastian Hoffmann, Manoj Lalu, Marcel Leist, and Martin L. Stephens | A66

Instruments for Assessing Risk of Bias and Other Methodological Criteria: Krauth et al. Respond

David Krauth, Tracey J. Woodruff, and Lisa Bero | A67


Erratum: “Exposure to Brominated Trihalomethanes in Water During Pregnancy and Micronuclei Frequency in Maternal and Cord Blood Lymphocytes”


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