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Environmental Health Perspectives

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March 2015 | Volume 123 | Issue 3


March 2015 CoverFocus

Hand-Me-Down Hazard: Flame Retardants in Discarded Foam Products

Kellyn S. Betts | A56

Furniture industry experts expect flame-retardant-free furnishings to become increasingly popular with consumers who can afford them, and people who purchase these items may reduce their exposures to certain flame retardants. But what happens to older furniture that enters the waste stream?

© Thomas Fredriksen/Shutterstock

Icons representing genetic diversity of human and mouse populationsSpheres of Influence

Diversity Outbred: A New Generation of Mouse Model

Charles W. Schmidt | A64

The use of genetically identical mice in toxicology studies can make it tricky to extrapolate findings to people. A new mouse model known as the Diversity Outbred better reflects the genetic diversity of the human population, offering intriguing possibilities for safety assessment.

© Roy Scott

Science Selections

Air Pollution and ASDs: Homing In on an Environmental Risk Factor

Carrie Arnold | A68

Also see Raz et al., p. 264

Comparing Models: DBP Effects in Rat and Human Germ Cells

Julia R. Barrett | A69

Also see van den Driesche et al., p. 223

Roadmap for Children’s Health: Controlling Diverse Environmental Exposures in Latin America

Carol Potera | A70

Also see Laborde et al., p. 201

Continental Reference Point: Harmonized Human Biomonitoring across Europe

Kris Freeman | A71

Also see Den Hond et al., p. 255


Children’s Health in Latin America: The Influence of Environmental Exposures

Amalia Laborde, Fernando Tomasina, Fabrizio Bianchi, Marie-Noel Bruné, Irena Buka, Pietro Comba, Lilian Corra, Liliana Cori, Christin Maria Duffert, Raul Harari, Ivano Iavarone, Melissa A. McDiarmid, Kimberly A. Gray, Peter D. Sly, Agnes Soares, William A. Suk, and Philip J. Landrigan | 201

Also see Science Selections, p. A70


Urinary Phthalate Metabolites and Biomarkers of Oxidative Stress in Pregnant Women: A Repeated Measures Analysis

Kelly K. Ferguson, Thomas F. McElrath, Yin-Hsiu Chen, Bhramar Mukherjee, and John D. Meeker | 210

Urinary Metals and Heart Rate Variability: A Cross-Sectional Study of Urban Adults in Wuhan, China

Wei Feng, Xiaosheng He, Mu Chen, Siyun Deng, Gaokun Qiu, Xiaoliang Li, Chuanyao Liu, Jun Li, Qifei Deng, Suli Huang, Tian Wang, Xiayun Dai, Binyao Yang, Jing Yuan, Meian He, Xiaomin Zhang, Weihong Chen, Haidong Kan, and Tangchun Wu | 217

Comparative Effects of Di(n-Butyl) Phthalate Exposure on Fetal Germ Cell Development in the Rat and in Human Fetal Testis Xenografts

Sander van den Driesche, Chris McKinnell, Ana Calarrão, Laura Kennedy, Gary R. Hutchison, Lenka Hrabalkova, Matthew S. Jobling, Sheila Macpherson, Richard A. Anderson, Richard M. Sharpe, and Rod T. Mitchell | 223

Also see Science Selections, p. A69

Src-Mediated EGF Receptor Activation Regulates Ozone-Induced Interleukin 8 Expression in Human Bronchial Epithelial Cells

Weidong Wu, Phillip A. Wages, Robert B. Devlin, David Diaz-Sanchez, David B. Peden, and James M. Samet | 231

Diversity Outbred Mice Identify Population-Based Exposure Thresholds and Genetic Factors that Influence Benzene-Induced Genotoxicity

John E. French, Daniel M. Gatti, Daniel L. Morgan, Grace E. Kissling, Keith R. Shockley, Gabriel A. Knudsen, Kim G. Shepard, Herman C. Price, Deborah King, Kristine L. Witt, Lars C. Pedersen, Steven C. Munger, Karen L. Svenson, and Gary A. Churchill | 237

Effects of Benzo[a]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF-κB Signaling

Qian Ba, Junyang Li, Chao Huang, Hongling Qiu, Jingquan Li, Ruiai Chu, Wei Zhang, Dong Xie, Yongning Wu, and Hui Wang | 246

Children’s Health

First Steps toward Harmonized Human Biomonitoring in Europe: Demonstration Project to Perform Human Biomonitoring on a European Scale

Elly Den Hond, Eva Govarts, Hanny Willems, Roel Smolders, Ludwine Casteleyn, Marike Kolossa-Gehring, Gerda Schwedler, Margarete Seiwert, Ulrike Fiddicke, Argelia Castaño, Marta Esteban, Jürgen Angerer, Holger M. Koch, Birgit K. Schindler, Ovnair Sepai, Karen Exley, Louis Bloemen, Milena Horvat, Lisbeth E. Knudsen, Anke Joas, Reinhard Joas, Pierre Biot, Dominique Aerts, Gudrun Koppen, Andromachi Katsonouri, Adamos Hadjipanayis, Andrea Krskova, Marek Maly, Thit A. Mørck, Peter Rudnai, Szilvia Kozepesy, Maurice Mulcahy, Rory Mannion, Arno C. Gutleb, Marc E. Fischer, Danuta Ligocka, Marek Jakubowski, M. Fátima Reis, Sónia Namorado, Anca Elena Gurzau, Ioana-Rodica Lupsa, Katarina Halzlova, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Ana López, Estrella Lopez, Marika Berglund, Kristin Larsson, Andrea Lehmann, Pierre Crettaz, and Greet Schoeters | 255

Also see Science Selections, p. A71

Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case–Control Analysis within the Nurses’ Health Study II Cohort

Raanan Raz, Andrea L. Roberts, Kristen Lyall, Jaime E. Hart, Allan C. Just, Francine Laden, and Marc G. Weisskopf | 264

Also see Science Selections, p. A68

Environmental Lead Exposure and Attention Deficit/Hyperactivity Disorder Symptom Domains in a Community Sample of South Korean School-Age Children

Soon-Beom Hong, Mee-Hyang Im, Jae-Won Kim, Eun-Jin Park, Min-Sup Shin, Boong-Nyun Kim, Hee-Jeong Yoo, In-Hee Cho, Soo-Young Bhang, Yun-Chul Hong, and Soo-Churl Cho | 271



Jenny Pronczuk de Garbino: A Global Champion for Children’s Health

Philip J. Landrigan and William A. Suk | A52

In Memoriam

Theodora (Theo) Colborn: 1927–2014

Elizabeth Grossman, Laura N. Vandenberg, Kristina Thayer, and Linda S. Birnbaum | A54

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