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Environmental Health Perspectives

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October 2009 | Volume 117 | Issue 10




October 2009 CoverEnvironmental Factors in Birth Defects: What We Need to Know

Bob Weinhold
A440–A447 |

Birth defects are a major cause of infant deaths, but a lack of money, coordinated monitoring efforts, and high-quality data hampers efforts to fully understand why these conditions occur. Much remains unknown about the causes of birth defects, although experts believe environmental factors may contribute. Now researchers are looking at new ways to collect, analyze, and share data to help better understand environmental contributions to birth defects.




Consumer Protection Act Sees Uneven Launch

Richard Dahl
A436–A436 |


Childhood Leukemia and Proximity to Nuclear Power Plants

Adrian Burton
A437–A437 |


Sweeteners Persist in Waterways

Rebecca Kessler
A438–A438 |


The Beat

Erin E. Dooley
A438–A438 |


Next Course in Organic Debate

David C. Holzman
A439–A439 |

Spheres of Influence


TOC_SpheresLearning Curve: Putting Healthy School Principles into Practice

With children spending about one-third of their day at school, so-called high-performance schools—designed to promote better attendance, achievement, and behavior by optimizing indoor air quality, ventilation, lighting, acoustics, and other elements of the built environment—could also provide children with the most pollution-free part of their day. But many children go to schools that are a far cry from this picture, and more than a few hurdles stand in the way to achieving high-performance schools. This article looks at ways some schools are overcoming those hurdles to create healthy learning environments.


Science Selections


Mass Lead Poisoning in Dakar: Battery Recycling Exacts a Heavy Toll

Carol Potera
A454–A454 |


Variable Vulnerability: Genotype Determines Timing of PON1 Capability to Detoxify Pesticides

Kris S. Freeman
A454–A454 |


Disinfection By-Products and Congenital Anomalies: Evidence Still Inconclusive

Angela Spivey
A455–A455 |


PBDEs in Diet: Meat Fat a Leading Source

Naomi Lubick
A455–A455 |




Malaria Control Insecticide Residues in Breast Milk: The Need to Consider Infant Health Risks

Hindrik Bouwman, Henrik Kylin
1477–1480 |


What Additional Factors Beyond State-of-the-Art Analytical Methods Are Needed for Optimal Generation and Interpretation of Biomonitoring Data?

Antonia M. Calafat, Larry L. Needham
1481–1485 |



Chlorination Disinfection By-Products in Drinking Water and Congenital Anomalies: Review and Meta-Analyses

Mark J. Nieuwenhuijsen, David Martinez, James Grellier, James Bennett, Nicky Best, Nina Iszatt, Martine Vrijheid, Mireille B. Toledano
1486–1493 |


Using National and Local Extant Data to Characterize Environmental Exposures in the National Children’s Study: Queens County, New York

Paul J. Lioy, Sastry S. Isukapalli, Leonardo Trasande, Lorna Thorpe, Michael Dellarco, Clifford Weisel, Panos G. Georgopoulos, Christopher Yung, Shahnaz Alimokhtari, Margot Brown, Philip J. Landrigan
1494–1504 |


A Systematic Review and Meta-analysis of Childhood Leukemia and Parental Occupational Pesticide Exposure

Donald T. Wigle, Michelle C. Turner, Daniel Krewski
1505–1513 |



Prediagnostic Serum Concentrations of Organochlorine Compounds and Risk of Testicular Germ Cell Tumors

Mark P. Purdue, Lawrence S. Engel, Hilde Langseth, Larry L. Needham, Aage Andersen, Dana B. Barr, Aaron Blair, Nathaniel Rothman, Katherine A. McGlynn
1514–1519 |


Diet Contributes Significantly to the Body Burden of PBDEs in the General U.S. Population

Alicia J. Fraser, Thomas F. Webster, Michael D. McClean
1520–1525 |


Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study

Chadi Yazbeck, Olivier Thiebaugeorges, Thierry Moreau, Valérie Goua, Ginette Debotte, Josiane Sahuquillo, Anne Forhan, Bernard Foliguet, Guillaume Magnin, Rémy Slama, Marie-Aline Charles, Guy Huel
1526–1530 |


Cumulative Lead Exposure and Tooth Loss in Men: The Normative Aging Study

Manish Arora, Jennifer Weuve, Marc G. Weisskopf, David Sparrow, Huiling Nie, Raul I. Garcia, Howard Hu
1531–1534 |


Mass Lead Intoxication from Informal Used Lead-Acid Battery Recycling in Dakar, Senegal

Pascal Haefliger, Monique Mathieu-Nolf, Stephanie Lociciro, Cheikh Ndiaye, Malang Coly, Amadou Diouf, Absa Lam Faye, Aminata Sow, Joanna Tempowski, Jenny Pronczuk, Antonio Pedro Filipe Junior, Roberto Bertollini, Maria Neira
1535–1540 |


Molecular Population Genetics of Human CYP3A Locus: Signatures of Positive Selection and Implications for Evolutionary Environmental Medicine

Xiaoping Chen, Haijian Wang, Gangqiao Zhou, Xiumei Zhang, Xiaojia Dong, Lianteng Zhi, Li Jin, Fuchu He
1541–1548 |


Perinatal Exposure to Bisphenol A Alters Early Adipogenesis in the Rat

Emmanuel Somm, Valérie M. Schwitzgebel, Audrey Toulotte, Christopher R. Cederroth, Christophe Combescure, Serge Nef, Michel L. Aubert, Petra S. Hüppi
1549–1555 |


Exposure to a Complex Cocktail of Environmental Endocrine-Disrupting Compounds Disturbs the Kisspeptin/GPR54 System in Ovine Hypothalamus and Pituitary Gland

Michelle Bellingham, Paul A. Fowler, Maria R. Amezaga, Stewart M. Rhind, Corinne Cotinot, Beatrice Mandon-Pepin, Richard M. Sharpe, Neil P. Evans
1556–1562 |


Evidence for Dose-Additive Effects of Pyrethroids on Motor Activity in Rats

Marcelo J. Wolansky, Chris Gennings, Michael J. DeVito, Kevin M. Crofton
1563–1570 |


Model Development and Validation of Personal Exposure to Volatile Organic Compound Concentrations

Juana Mari Delgado-Saborit, Noel J. Aquilina, Claire Meddings, Stephen Baker, Roy M. Harrison
1571–1579 |

Children’s Health


Postnatal Cadmium Exposure, Neurodevelopment, and Blood Pressure in Children at 2, 5, and 7 Years of Age

Yang Cao, Aimin Chen, Jerilynn Radcliffe, Kim N. Dietrich, Robert L. Jones, Kathleen Caldwell, Walter J. Rogan
1580–1586 |


Urinary Phthalate Metabolites in Relation to Preterm Birth in Mexico City

John D. Meeker, Howard Hu, David E. Cantonwine, Hector Lamadrid-Figueroa, Antonia M. Calafat, Adrienne S. Ettinger, Mauricio Hernandez-Avila, Rita Loch-Caruso, Martha María Téllez-Rojo
1587–1592 |


Predictors of Serum Dioxins and PCBs among Peripubertal Russian Boys

Jane S. Burns, Paige L. Williams, Oleg Sergeyev, Susan Korrick, Mary M. Lee, Boris Revich, Larisa Altshul, Donald G. Patterson, Wayman E. Turner, Larry L. Needham, Igor Saharov, Russ Hauser
1593–1599 |


Exposure to Hydroxylated Polychlorinated Biphenyls (OH-PCBs) in the Prenatal Period and Subsequent Neurodevelopment in Eastern Slovakia

Hye-Youn Park, June-Soo Park, Eva Sovcikova, Anton Kocan, Linda Linderholm, Ake Bergman, Tomas Trnovec, Irva Hertz-Picciotto
1600–1606 |


Lead Exposure and Behavior among Young Children in Chennai, India

Ananya Roy, David Bellinger, Howard Hu, Joel Schwartz, Adrienne S. Ettinger, Robert O. Wright, Maryse Bouchard, Kavitha Palaniappan, Kalpana Balakrishnan
1607–1611 |


Association of Traffic-Related Air Pollution with Children’s Neurobehavioral Functions in Quanzhou, China

Shunqin Wang, Jinliang Zhang, Xiaodong Zeng, Yimin Zeng, Shengchun Wang, Shuyun Chen
1612–1618 |


Drinking-Water Herbicide Exposure in Indiana and Prevalence of Small-for-Gestational-Age and Preterm Delivery

Hugo Ochoa-Acuña, Jane Frankenberger, Leighanne Hahn, Cristina Carbajo
1619–1624 |


Do Human Milk Concentrations of Persistent Organic Chemicals Really Decline During Lactation? Chemical Concentrations During Lactation and Milk/Serum Partitioning

Judy S. LaKind, Cheston M. Berlin, Andreas Sjödin, Wayman Turner, Richard Y. Wang, Larry L. Needham, Ian M. Paul, Jennifer L. Stokes, Daniel Q. Naiman, Donald G. Patterson
1625–1631 |


Developmental Changes in PON1 Enzyme Activity in Young Children and Effects of PON1 Polymorphisms

Karen Huen, Kim Harley, Jordan Brooks, Alan Hubbard, Asa Bradman, Brenda Eskenazi, Nina Holland
1632–1638 |





Are We Really Addressing the Core of Children’s Environmental Health?

Nsedu Obot Witherspoon
A428–A429 |



Concerns of CropLife America Regarding the Application and Use of the U.S. EPA’s Toxicity Reference Database

Erik Janus
A432–A432 |


U.S. EPA’s Toxicity Reference Database: Martin and Dix Respond

Matthew T. Martin, David J. Dix
A432–A433 |


Nanotechnology-Related Environment, Health, and Safety Research

Giovanni Brandi, Elisabetta Nobili, Stefania Di Girolamo, Gianluca Grazi, Michelangelo Fiorentino, Rita Golfieri, Guido Biasco
A433–A434 |

Book Review


Book Review: Environmental Health and Child Survival: Epidemiology, Economics, Experiences

Leonardo Trasande
A464–A464 |
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