Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005–2010

http://dx.doi.org/10.1289/ehp.1206372



Table 3. Associations between serum PFOA and PFOS and preterm birth (< 37 weeks).
PFC metric Crude OR
All births
n = 1,628 (158 cases)
Adjusteda OR (95% CI)
All births
= 1,628 (158 cases)
Adjusteda OR (95% CI)
First prospectiveb = 783 (73 cases)
aAdjusted for maternal age (cubic terms), educational level (< 12 years, 12, 13–15, ≥ 16), smoking status (current, former, non), parity (0, ≥ 1), BMI (underweight, normal, overweight, obese), self-reported diabetes, time between conception and serum measurement (year strata). bFirst pregnancy conceived after serum measurement among nonpregnant women. cUntransformed, IQR PFOS = 10 ng/mL, IQR PFOA = 22 ng/mL.
PFOA      
Per in unit increase 0.95 0.93 (0.78, 1.10) 1.09 (0.86, 1.37)
Per IQR increasec 0.96 0.95 (0.88, 1.04) 1.01 (0.92, 1.10)
Quintile (ng/mL)   p-trend = 0.629 p-trend = 0.409
0 to < 6.9 1.0 (reference) 1.0 (reference) 1.0 (reference)
6.9 to < 11.1 1.69 1.56 (0.88, 2.76) 1.11 (0.42, 2.89)
11.1 to < 18.9 1.26 1.19 (0.66, 2.14) 1.30 (0.51, 3.27)
18.9 to < 37.2 1.32 1.21 (0.67, 2.19) 1.49 (0.62, 3.61)
≥ 37.2 1.13 1.01 (0.55, 1.86) 1.32 (0.53, 3.32)
PFOS      
Per in unit increase 1.04 1.02 (0.78, 1.35) 1.02 (0.72, 1.45)
Per IQR increasec 1.03 1.03 (0.83, 1.27) 0.95 (0.73, 1.25)
Quintile (ng/mL)   p-trend = 0.976 p-trend = 0.818
0 to < 8.6 1.0 (reference) 1.0 (reference) 1.0 (reference)
8.6 to < 12.1 1.21 1.11 (0.63, 1.94) 1.07 (0.44, 2.59)
12.1 to < 15.9 0.82 0.76 (0.42, 1.36) 0.63 (0.25, 1.59)
15.9 to < 21.4 1.09 1.00 (0.56, 1.78) 1.08 (0.47, 2.46)
≥ 21.4 1.09 1.07 (0.58, 1.95) 0.86 (0.36, 2.04)