Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005–2010

http://dx.doi.org/10.1289/ehp.1206372



Table 5. Associations between serum PFOA and PFOS and low birth weight (< 2,500 g).
PFC metric Crude OR
All births
n = 1,629 (88 cases)
Adjusteda OR (95% CI)
All births
= 1,629 (88 cases)
Adjusteda OR (95% CI)
First prospectiveb = 783 (45 cases)
aAdjusted for maternal age (cubic terms), educational level (< 12 years, 12, 13–15, ≥ 16), smoking status (current, former, non), parity (0, ≥ 1), BMI (underweight, normal, overweight, obese), self-reported diabetes, time between conception and serum measurement (year strata). bFirst pregnancy conceived after serum measurement among nonpregnant women. cUntransformed, IQR PFOS = 10 ng/mL, IQR PFOA = 22 ng/mL.
PFOA      
Per in unit increase 0.98 0.94 (0.75, 1.17) 1.07 (0.78, 1.47)
Per IQR increasec 0.97 0.95 (0.85, 1.06) 0.99 (0.87, 1.12)
Quintile (ng/mL)   p-trend = 0.883 p-trend = 0.433
0 to < 6.9 1.0 (reference) 1.0 (reference) 1.0 (reference)
6.9 to < 11.1 0.94 0.94 (0.45, 1.98) 0.82 (0.23, 2.85)
11.1 to < 18.9 0.96 0.99 (0.48, 2.05) 1.03 (0.35, 3.06)
18.9 to < 37.2 1.12 1.25 (0.63, 2.46) 1.86 (0.67, 5.14)
≥ 37.2 0.89 0.92 (0.44, 1.95) 1.06 (0.32, 3.54)
PFOS      
Per in unit increase 1.12 1.12 (0.75, 1.67) 0.97 (0.61, 1.54)
Per IQR increasec 1.12 1.12 (0.87, 1.44) 0.93 (0.63, 1.37)
Quintile (ng/mL)   p-trend = 0.651 p-trend = 0.484
0 to < 8.6 1.0 (reference) 1.0 (reference) 1.0 (reference)
8.6 to < 12.1 1.46 1.48 (0.71, 3.08) 1.65 (0.52, 5.20)
12.1 to < 15.9 1.31 1.23 (0.57, 2.65) 0.95 (0.30, 3.01)
15.9 to < 21.4 1.29 1.31 (0.59, 2.94) 1.17 (0.36, 3.78)
≥ 21.4 1.34 1.33 (0.60, 2.96) 0.82 (0.25, 2.70)