Serum Perfluorooctanoic Acid and Perfluorooctane Sulfonate Concentrations in Relation to Birth Outcomes in the Mid-Ohio Valley, 2005–2010

http://dx.doi.org/10.1289/ehp.1206372



Table 6. Associations between serum PFOA and PFOS and birth weight in full-term infants.
PFC metric Crude ∆ grams
All births
n = 1,470
Adjusteda ∆ grams (95% CI)
All births
= 1,470
Adjusteda ∆ grams (95% CI) First prospectiveb
n = 710
aAdjusted for maternal age, educational level (< 12 years, 12, 13–15, ≥ 16), smoking status (current, former, non), parity (0, ≥ 1), BMI (underweight, normal, overweight, obese), self-reported diabetes, time between conception and serum measurement (year strata), indicator variables for gestational week (37, 38, 39, 40, ≥ 41). bFirst pregnancy conceived after serum measurement among nonpregnant women. cUntransformed, IQR PFOS = 10 ng/mL, IQR PFOA = 22 ng/mL.
PFOA      
Per in unit increase –9 –8 (–28, 12) 5 (–22, 33)
Per IQR increasec –5 –5 (–13, 2) 1 (–10, 11)
Quintile (ng/mL)   p-trend = 0.701 p-trend = 0.622
0 to < 6.9 0 (reference) 0 (reference) 0 (reference)
6.9 to < 11.1 21 35 (–33, 105) 135 (34, 236)
11.1 to < 18.9 –35 –9 (–79, 61) 26 (–71, 124)
18.9 to < 37.2 –1 4 (–65, 72) 56 (–37, 149)
≥ 37.2 –3 0 (–68, 69) 74 (–20, 169)
PFOS      
Per in unit increase –18 –29 (–66, 7) –49 (–90, –8)
Per IQR increasec –12 –23 (–48, 3) –29 (–58, 0)
Quintile (ng/mL)   p-trend = 0.045 p-trend = 0.006
0 to < 8.6 0 (reference) 0 (reference) 0 (reference)
8.6 to < 12.1 0 –25 (–96, 48) –33 (–140, 74)
12.1 to < 15.9 –45 –37 (–109, 35) –115 (–216, –14)
15.9 to < 21.4 –76 –83 (–152, –13) –149 (–244, –54)
≥ 21.4 –14 –54 (–124, 17) –105 (–196, –13)