Perfluorooctanoic Acid (PFOA) Exposures and Incident Cancers among Adults Living Near a Chemical Plant

http://dx.doi.org/10.1289/ehp.1306615



Table 4. HRs (95% CIs) for the effect of logged estimated cumulative PFOA serum concentration on ­cancer risk in the cohort (n = 32,254).
Cancera No. of casesb No lag 10-year lag
HR (95% CI)c p-Value HR (95% CI)c p-Value
aA proportional hazards regression model was run for each cancer; each model was adjusted for time-varying smoking, time-varying alcohol consumption, sex, education, and stratified by 5-year period of birth year; time began at age 20 years if the person’s 20th birthday was in 1952 or later, otherwise time began at the age the person was in 1952; time ended at the age of cancer diagnosis, age at the last follow-up survey, or age on 31 December 2011, whichever came first. bNumber of cancer cases used in the regression model (i.e., no missing data for any of the model’s covariates). cPer unit of log estimated cumulative PFOA serum concentration (ng/mL).
Bladder 105 1.00 (0.89, 1.12) 0.98 0.98 (0.88, 1.10) 0.77
Brain 17 1.13 (0.84, 1.51) 0.43 1.06 (0.79, 1.41) 0.70
Breast 559 0.94 (0.89, 1.00) 0.05 0.93 (0.88, 0.99) 0.03
Cervical 22 0.89 (0.63, 1.24) 0.48 0.98 (0.69, 1.38) 0.90
Colorectal 264 0.99 (0.92, 1.07) 0.84 0.99 (0.92, 1.07) 0.77
Esophagus 15 0.96 (0.70, 1.32) 0.82 0.97 (0.72, 1.31) 0.84
Kidney 105 1.10 (0.98, 1.24) 0.10 1.09 (0.97, 1.21) 0.15
Leukemia 66 1.01 (0.87, 1.18) 0.88 1.02 (0.88, 1.18) 0.80
Liver 9 0.73 (0.43, 1.23) 0.23 0.74 (0.43, 1.26) 0.26
Lung 108 0.88 (0.78, 1.00) 0.05 0.92 (0.81, 1.04) 0.17
Lymphoma 136 1.01 (0.91, 1.12) 0.88 0.98 (0.88, 1.10) 0.78
Melanoma 241 1.00 (0.92, 1.09) 0.97 1.04 (0.96, 1.13) 0.30
Oral 18 0.89 (0.65, 1.22) 0.46 0.66 (0.43, 1.02) 0.06
Ovarian 43 0.95 (0.76, 1.19) 0.64 0.90 (0.69, 1.16) 0.42
Pancreatic 24 1.00 (0.78, 1.29) 0.99 0.96 (0.75, 1.22) 0.72
Prostate 446 0.99 (0.93, 1.04) 0.63 0.99 (0.94, 1.05) 0.80
Soft tissue 15 0.75 (0.51, 1.10) 0.14 0.72 (0.48, 1.09) 0.12
Stomach 12 0.72 (0.45, 1.14) 0.16 0.77 (0.49, 1.22) 0.27
Testicular 17 1.34 (1.00, 1.79) 0.05 1.28 (0.95, 1.73) 0.10
Thyroid 86 1.10 (0.95, 1.26) 0.20 1.04 (0.89, 1.20) 0.65
Uterine 103 1.05 (0.91, 1.20) 0.53 0.99 (0.86, 1.15) 0.94